LAIR1

{{for|19q13.4|Chromosome 19#Cytogenetic band}}

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells.{{cite journal | vauthors = van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L | title = Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling | journal = European Journal of Immunology | volume = 29 | issue = 10 | pages = 3160–7 | date = October 1999 | pmid = 10540327 | doi = 10.1002/(SICI)1521-4141(199910)29:10<3160::AID-IMMU3160>3.0.CO;2-S | doi-access = free }} Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

LAIR1 has been shown to interact with PTPN11{{cite journal | vauthors = Fournier N, Chalus L, Durand I, Garcia E, Pin JJ, Churakova T, Patel S, Zlot C, Gorman D, Zurawski S, Abrams J, Bates EE, Garrone P | title = FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells | journal = J. Immunol. | volume = 165 | issue = 3 | pages = 1197–209 | date = August 2000 | pmid = 10903717 | doi = 10.4049/jimmunol.165.3.1197 | doi-access = free }} and PTPN6.{{cite journal | vauthors = Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ, Matthews RJ | title = Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells | journal = J. Immunol. | volume = 166 | issue = 3 | pages = 1763–70 | date = February 2001 | pmid = 11160222 | doi = 10.4049/jimmunol.166.3.1763 | doi-access = free }}{{cite journal | vauthors = Mousseau DD, Banville D, L'Abbé D, Bouchard P, Shen SH | title = PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta | journal = J. Biol. Chem. | volume = 275 | issue = 6 | pages = 4467–74 | date = February 2000 | pmid = 10660620 | doi = 10.1074/jbc.275.6.4467 | doi-access = free | url = https://www.openaccessrepository.it/record/94145/files/fulltext.pdf | archive-url = https://web.archive.org/web/20240202204316/https://www.openaccessrepository.it/record/94145/files/fulltext.pdf | url-status = dead | archive-date = February 2, 2024 }}{{cite journal | vauthors = ((Xu Mj)), Zhao R, Zhao ZJ | title = Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells | journal = J. Biol. Chem. | volume = 275 | issue = 23 | pages = 17440–6 | date = June 2000 | pmid = 10764762 | doi = 10.1074/jbc.M001313200 | doi-access = free }}

{{Reflist}}

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• {{cite journal | vauthors = Sinclair NR | title = Why so many coinhibitory receptors? | journal = Scand. J. Immunol. | volume = 50 | issue = 1 | pages = 10–3 | year = 1999 | pmid = 10404045 | doi = 10.1046/j.1365-3083.1999.00580.x | s2cid = 10345478 | doi-access = free }}
• {{cite book | vauthors = Meyaard L | chapter = LAIR-1, a Widely Distributed Human ITIM-Bearing Receptor on Hematopoietic Cells | title = Immunoreceptor Tyrosine-based Inhibition Motifs | journal = Current Topics in Microbiology and Immunology | volume = 244 | pages = 151–7 | year = 1999 | pmid = 10453657 | doi = 10.1007/978-3-642-58537-1_13 | isbn = 978-3-540-65789-7 | series = Current Topics in Microbiology 244 and Immunology }}
• {{cite journal | vauthors = Meyaard L | title = Leukocyte associated Ig-like receptor (LAIR) | journal = J. Biol. Regul. Homeost. Agents | volume = 17 | issue = 4 | pages = 330–3 | year = 2004 | pmid = 15065762 }}
• {{cite journal | vauthors = Poggi A, Tomasello E, Ferrero E, Zocchi MR, Moretta L | title = p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor | journal = Eur. J. Immunol. | volume = 28 | issue = 7 | pages = 2086–91 | year = 1998 | pmid = 9692876 | doi = 10.1002/(SICI)1521-4141(199807)28:07<2086::AID-IMMU2086>3.0.CO;2-T | s2cid = 21655416 | doi-access = free }}
• {{cite journal | vauthors = Meyaard L, Hurenkamp J, Clevers H, Lanier LL, Phillips JH | title = Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells | journal = J. Immunol. | volume = 162 | issue = 10 | pages = 5800–4 | year = 1999 | doi = 10.4049/jimmunol.162.10.5800 | pmid = 10229813 | s2cid = 14882830 | doi-access = free }}
• {{cite journal | vauthors = Poggi A, Pellegatta F, Leone BE, Moretta L, Zocchi MR | title = Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias | journal = Eur. J. Immunol. | volume = 30 | issue = 10 | pages = 2751–8 | year = 2000 | pmid = 11069054 | doi = 10.1002/1521-4141(200010)30:10<2751::AID-IMMU2751>3.0.CO;2-L | doi-access = free }}
• {{cite journal | vauthors = Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ, Matthews RJ | title = Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells | journal = J. Immunol. | volume = 166 | issue = 3 | pages = 1763–70 | year = 2001 | pmid = 11160222 | doi = 10.4049/jimmunol.166.3.1763 | doi-access = free }}
• {{cite journal | vauthors = Saverino D, Fabbi M, Merlo A, Ravera G, Grossi CE, Ciccone E | title = Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions | journal = Hum. Immunol. | volume = 63 | issue = 7 | pages = 534–46 | year = 2002 | pmid = 12072189 | doi = 10.1016/S0198-8859(02)00409-3 }}
• {{cite journal | vauthors = Aoukaty A, Lee IF, Wu J, Tan R | title = Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells | journal = J. Clin. Immunol. | volume = 23 | issue = 2 | pages = 141–5 | year = 2003 | pmid = 12757266 | doi = 10.1023/A:1022580929226 | s2cid = 31461585 }}
• {{cite journal | vauthors = Verbrugge A, de Ruiter T, Clevers H, Meyaard L | title = Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment | journal = Int. Immunol. | volume = 15 | issue = 11 | pages = 1349–58 | year = 2003 | pmid = 14565933 | doi = 10.1093/intimm/dxg134 | doi-access = }}
• {{cite journal | vauthors = De Milito A, Nilsson A, Titanji K, Thorstensson R, Reizenstein E, Narita M, Grutzmeier S, Sönnerborg A, Chiodi F | title = Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection | journal = Blood | volume = 103 | issue = 6 | pages = 2180–6 | year = 2004 | pmid = 14604962 | doi = 10.1182/blood-2003-07-2375 | doi-access = }}

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• {{MeshName|LAIR1+protein,+human}}
• {{PDBe-KB2|Q6GTX8|Leukocyte-associated immunoglobulin-like receptor 1}}

{{NLM content}}

{{Clusters of differentiation}}

Category:Clusters of differentiation

Category:Immunoglobulin superfamily

{{immunology-stub}}

{{Membrane-protein-stub}}