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LAT2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Linker for activation of T-cells family member 2 is a protein that in humans is encoded by the LAT2 gene.{{cite journal |vauthors=Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC | title = Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients | journal = Genomics | volume = 36 | issue = 2 | pages = 328–36 |date=Jan 1997 | pmid = 8812460 | doi = 10.1006/geno.1996.0469 | doi-access = free }}{{cite journal |vauthors=Janssen E, Zhu M, Zhang W, Koonpaew S, Zhang W | title = LAB: a new membrane-associated adaptor molecule in B cell activation | journal = Nat Immunol | volume = 4 | issue = 2 | pages = 117–23 |date=Jan 2003 | pmid = 12514734 | doi = 10.1038/ni882 | s2cid = 23727758 }}{{cite web | title = Entrez Gene: LAT2 linker for activation of T cells family, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7462}}

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.

References

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Further reading

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  • {{cite journal | author=Rivera J |title=NTAL/LAB and LAT: a balancing act in mast-cell activation and function |journal=Trends Immunol. |volume=26 |issue= 3 |pages= 119–22 |year= 2005 |pmid= 15745852 |doi= 10.1016/j.it.2005.01.001 }}
  • {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | author=Pérez Jurado LA |title=Molecular definition of the chromosome 7 deletion in Williams syndrome and parent-of-origin effects on growth |journal=Am. J. Hum. Genet. |volume=59 |issue= 4 |pages= 781–92 |year= 1996 |pmid= 8808592 | pmc=1914804 |name-list-style=vanc| author2=Peoples R | author3=Kaplan P | display-authors=3 | last4=Hamel | first4=BC | last5=Francke | first5=U }}
  • {{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-style=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=A | last5=Sugano | first5=S }}
  • {{cite journal | author=Martindale DW |title=Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23 |journal=Mamm. Genome |volume=11 |issue= 10 |pages= 890–8 |year= 2000 |pmid= 11003705 |doi=10.1007/s003350010166 |name-list-style=vanc| author2=Wilson MD | author3=Wang D | display-authors=3 | last4=Burke | first4=Robert D. | last5=Chen | first5=Xianming | last6=Duronio | first6=Vincent | last7=Koop | first7=Ben F. |s2cid=8575994 }}
  • {{cite journal | author=Zhang QH |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 |name-list-style=vanc| author2=Ye M | author3=Wu XY | display-authors=3 | last4=Ren | first4=SX | last5=Zhao | first5=M | last6=Zhao | first6=CJ | last7=Fu | first7=G | last8=Shen | first8=Y | last9=Fan | first9=HY }}
  • {{cite journal |vauthors=Doyle JL, DeSilva U, Miller W, Green ED |title=Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome |journal=Cytogenet. Cell Genet. |volume=90 |issue= 3–4 |pages= 285–90 |year= 2001 |pmid= 11124535 |doi=10.1159/000056790 |s2cid=34058309 }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD | bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | author=Brdicka T |title=Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling |journal=J. Exp. Med. |volume=196 |issue= 12 |pages= 1617–26 |year= 2003 |pmid= 12486104 |doi=10.1084/jem.20021405 | pmc=2196071 |name-list-style=vanc| author2=Imrich M | author3=Angelisová P | display-authors=3 | last4=Brdickova | first4=N. | last5=Horvath | first5=O. | last6=Spicka | first6=J. | last7=Hilgert | first7=I. | last8=Luskova | first8=P. | last9=Draber | first9=P. }}
  • {{cite journal | author=Hillier LW |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |name-list-style=vanc| author2=Fulton RS | author3=Fulton LA | display-authors=3 | last4=Graves | first4=Tina A. | last5=Pepin | first5=Kymberlie H. | last6=Wagner-Mcpherson | first6=Caryn | last7=Layman | first7=Dan | last8=Maas | first8=Jason | last9=Jaeger | first9=Sara |bibcode=2003Natur.424..157H | doi-access=free }}
  • {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
  • {{cite journal |vauthors=Koonpaew S, Janssen E, Zhu M, Zhang W |title=The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11229–35 |year= 2004 |pmid= 14722116 |doi= 10.1074/jbc.M311394200 |doi-access= free }}
  • {{cite journal | author=Tkaczyk C |title=NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation |journal=Blood |volume=104 |issue= 1 |pages= 207–14 |year= 2004 |pmid= 15010370 |doi= 10.1182/blood-2003-08-2769 |name-list-style=vanc| author2=Horejsi V | author3=Iwaki S | display-authors=3 | last4=Draber | first4=P | last5=Samelson | first5=LE | last6=Satterthwaite | first6=AB | last7=Nahm | first7=DH | last8=Metcalfe | first8=DD | last9=Gilfillan | first9=AM | doi-access=free }}
  • {{cite journal |vauthors=Janssen E, Zhu M, Craven B, Zhang W |title=Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding |journal=J. Immunol. |volume=172 |issue= 11 |pages= 6810–9 |year= 2004 |pmid= 15153499 |doi= 10.4049/jimmunol.172.11.6810|doi-access=free }}
  • {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Tedoldi S |title=Transmembrane adaptor molecules: a new category of lymphoid-cell markers |journal=Blood |volume=107 |issue= 1 |pages= 213–21 |year= 2006 |pmid= 16160011 |doi= 10.1182/blood-2005-06-2273 |name-list-style=vanc| author2=Paterson JC | author3=Hansmann ML | display-authors=3 | last4=Natkunam | first4=Y | last5=Rüdiger | first5=T | last6=Angelisova | first6=P | last7=Du | first7=MQ | last8=Roberton | first8=H | last9=Roncador | first9=G |s2cid=340034 | doi-access=free }}
  • {{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-style=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija |bibcode=2005Natur.437.1173R |s2cid=4427026 }}

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