LCMT2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Leucine carboxyl methyltransferase 2 is an enzyme that in humans is encoded by the LCMT2 gene.{{cite journal |vauthors=Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 1 | pages = 31–9 |date=Aug 1998 | pmid = 9628581 | doi =10.1093/dnares/5.1.31 | doi-access = free }}{{cite journal |vauthors=Noma A, Suzuki T | title = Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis | journal = Nucleic Acids Symp Ser (Oxf) | volume = 50| issue = 50 | pages = 65–6 |date=Dec 2006 | pmid = 17150819 | doi = 10.1093/nass/nrl032 }}{{cite web | title = Entrez Gene: LCMT2 leucine carboxyl methyltransferase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9836}}
The protein encoded by this intronless gene belongs to the methyltransferase superfamily and acts as a G1/S and G2/M phase checkpoint regulator. It has been hypothesized that cigarette smoke-induced oxidative stress and transforming growth factor beta 1 may inhibit cellular proliferation by modulating the expression of this protein.
References
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Further reading
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- {{cite journal |vauthors=De Baere I, Derua R, Janssens V, etal |title=Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue |journal=Biochemistry |volume=38 |issue= 50 |pages= 16539–47 |year= 2000 |pmid= 10600115 |doi=10.1021/bi991646a }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Marwick JA, Kirkham P, Gilmour PS, etal |title=Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells |journal=Ann. N. Y. Acad. Sci. |volume=973 |pages= 278–83 |year= 2003 |pmid= 12485877 |doi=10.1111/j.1749-6632.2002.tb04649.x |s2cid=84732926 }}
- {{cite journal |vauthors=Ng CC, Arakawa H, Fukuda S, etal |title=p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1 |journal=Oncogene |volume=22 |issue= 28 |pages= 4449–58 |year= 2003 |pmid= 12853982 |doi= 10.1038/sj.onc.1206586 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Kawamata N, Inagaki N, Mizumura S, etal |title=Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders |journal=Eur. J. Haematol. |volume=74 |issue= 5 |pages= 424–9 |year= 2005 |pmid= 15813917 |doi= 10.1111/j.1600-0609.2005.00417.x |s2cid=46197026 }}
- {{cite journal |vauthors=Noma A, Kirino Y, Ikeuchi Y, Suzuki T |title=Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA |journal=EMBO J. |volume=25 |issue= 10 |pages= 2142–54 |year= 2006 |pmid= 16642040 |doi= 10.1038/sj.emboj.7601105 | pmc=1462984 }}
- {{cite journal |vauthors=Liu FY, Qi JP, Xu FL, Wu AP |title=Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor |journal=World J. Gastroenterol. |volume=12 |issue= 26 |pages= 4161–5 |year= 2006 |doi=10.3748/wjg.v12.i26.4161 |pmid= 16830365 |pmc=4087364 |doi-access=free }}
- {{cite journal |vauthors=Moon SK, Choi YH, Kim CH, Choi WS |title=p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1 |journal=Biochem. Biophys. Res. Commun. |volume=350 |issue= 3 |pages= 662–8 |year= 2006 |pmid= 17026958 |doi= 10.1016/j.bbrc.2006.09.092 }}
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