LCP1

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.{{cite web | title = Entrez Gene: LCP1 lymphocyte cytosolic protein 1 (L-plastin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3936}}

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• {{cite journal | vauthors = Namba Y, Ito M, Zu Y, Shigesada K, Maruyama K | title = Human T cell L-plastin bundles actin filaments in a calcium-dependent manner | journal = Journal of Biochemistry | volume = 112 | issue = 4 | pages = 503–7 | date = October 1992 | pmid = 1491005 | doi = 10.1093/oxfordjournals.jbchem.a123929}}
• {{cite journal | vauthors = Zu YL, Shigesada K, Nishida E, Kubota I, Kohno M, Hanaoka M, Namba Y | title = 65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites | journal = Biochemistry | volume = 29 | issue = 36 | pages = 8319–24 | date = September 1990 | pmid = 2252891 | doi = 10.1021/bi00488a017 }}
• {{cite journal | vauthors = Lin CS, Aebersold RH, Leavitt J | title = Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain | journal = Molecular and Cellular Biology | volume = 10 | issue = 4 | pages = 1818–21 | date = April 1990 | pmid = 2378651 | pmc = 362293 | doi = 10.1128/MCB.10.4.1818}}
• {{cite journal | vauthors = Lin CS, Aebersold RH, Kent SB, Varma M, Leavitt J | title = Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts | journal = Molecular and Cellular Biology | volume = 8 | issue = 11 | pages = 4659–68 | date = November 1988 | pmid = 3211125 | pmc = 365555 | doi = 10.1128/MCB.8.11.4659}}
• {{cite journal | vauthors = Matsushima K, Shiroo M, Kung HF, Copeland TD | title = Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1 | journal = Biochemistry | volume = 27 | issue = 10 | pages = 3765–70 | date = May 1988 | pmid = 3261603 | doi = 10.1021/bi00410a037 }}
• {{cite journal | vauthors = Kondo I, Shin K, Honmura S, Nakajima H, Yamamura E, Satoh H, Terauchi M, Usuki Y, Takita H, Hamaguchi H | title = A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13 | journal = Human Genetics | volume = 71 | issue = 3 | pages = 263–6 | year = 1986 | pmid = 3864729 | doi = 10.1007/BF00284588 | s2cid = 11261385 }}
• {{cite journal | vauthors = Arpin M, Friederich E, Algrain M, Vernel F, Louvard D | title = Functional differences between L- and T-plastin isoforms | journal = The Journal of Cell Biology | volume = 127 | issue = 6 Pt 2 | pages = 1995–2008 | date = December 1994 | pmid = 7806577 | pmc = 2120298 | doi = 10.1083/jcb.127.6.1995 }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Lin CS, Shen W, Chen ZP, Tu YH, Matsudaira P | title = Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney | journal = Molecular and Cellular Biology | volume = 14 | issue = 4 | pages = 2457–67 | date = April 1994 | pmid = 8139549 | pmc = 358613 | doi = 10.1128/mcb.14.4.2457 }}
• {{cite journal | vauthors = Lin CS, Park T, Chen ZP, Leavitt J | title = Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells | journal = The Journal of Biological Chemistry | volume = 268 | issue = 4 | pages = 2781–92 | date = February 1993 | doi = 10.1016/S0021-9258(18)53842-4 | pmid = 8428952 | doi-access = free }}
• {{cite journal | vauthors = Lin CS, Chen ZP, Park T, Ghosh K, Leavitt J | title = Characterization of the human L-plastin gene promoter in normal and neoplastic cells | journal = The Journal of Biological Chemistry | volume = 268 | issue = 4 | pages = 2793–801 | date = February 1993 | doi = 10.1016/S0021-9258(18)53843-6 | pmid = 8428953 | doi-access = free }}
• {{cite journal | vauthors = Jones SL, Brown EJ | title = FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils | journal = The Journal of Biological Chemistry | volume = 271 | issue = 24 | pages = 14623–30 | date = June 1996 | pmid = 8663066 | doi = 10.1074/jbc.271.24.14623 | doi-access = free }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Okumura Y, Yano M, Murakami M, Mori S, Towatari T, Kido H | title = The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin | journal = FEBS Letters | volume = 442 | issue = 1 | pages = 39–42 | date = January 1999 | pmid = 9923600 | doi = 10.1016/S0014-5793(98)01612-3 | s2cid = 40872647 | doi-access = free }}
• {{cite journal | vauthors = Wang J, Brown EJ | title = Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A | journal = The Journal of Biological Chemistry | volume = 274 | issue = 34 | pages = 24349–56 | date = August 1999 | pmid = 10446213 | doi = 10.1074/jbc.274.34.24349 | doi-access = free }}
• {{cite journal | vauthors = Lin CS, Lau A, Yeh CC, Chang CH, Lue TF | title = Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences | journal = DNA and Cell Biology | volume = 19 | issue = 1 | pages = 1–7 | date = January 2000 | pmid = 10668786 | doi = 10.1089/104454900314654 }}
• {{cite journal | vauthors = Jia J, Han Q, Borregaard N, Lollike K, Cygler M | title = Crystal structure of human grancalcin, a member of the penta-EF-hand protein family | journal = Journal of Molecular Biology | volume = 300 | issue = 5 | pages = 1271–81 | date = July 2000 | pmid = 10903868 | doi = 10.1006/jmbi.2000.3925 }}
• {{cite journal | vauthors = Lollike K, Johnsen AH, Durussel I, Borregaard N, Cox JA | title = Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 17762–9 | date = May 2001 | pmid = 11279160 | doi = 10.1074/jbc.M100965200 | doi-access = free }}
• {{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein-protein interaction panel using mouse full-length cDNAs | journal = Genome Research | volume = 11 | issue = 10 | pages = 1758–65 | date = October 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}

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Category:EF-hand-containing proteins