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LCTL

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{About|the protein|the linguistics term|Less Commonly Taught Languages}}

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Lactase-like is a protein that in humans is encoded by the LCTL gene.{{cite web| title = Entrez Gene: Lactase-like| url = https://www.ncbi.nlm.nih.gov/gene/197021| access-date = 2013-09-25 }} Lactase-like is a glycosidase enzyme.

Function

This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

References

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Further reading

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  • {{cite journal | vauthors = Kim J, Eskiocak U, Stadler G, Lou Z, Kuro-o M, Shay JW, Wright WE | title = Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells | journal = The Journal of Biological Chemistry | volume = 286 | issue = 50 | pages = 43294–300 | date = December 2011 | pmid = 22020932 | pmc = 3234855 | doi = 10.1074/jbc.M111.267641 | doi-access = free }}
  • {{cite journal | vauthors = Mian IS | title = Sequence, structural, functional, and phylogenetic analyses of three glycosidase families | journal = Blood Cells, Molecules & Diseases | volume = 24 | issue = 2 | pages = 83–100 | date = June 1998 | pmid = 9779294 | doi = 10.1006/bcmd.1998.9998 | url = https://zenodo.org/record/1229538 }}
  • {{cite journal | vauthors = Ito S, Fujimori T, Hayashizaki Y, Nabeshima Y | title = Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1576 | issue = 3 | pages = 341–5 | date = July 2002 | pmid = 12084582 | doi = 10.1016/S0167-4781(02)00281-6 }}

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Category:Genes on human chromosome 15

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