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LDOC1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Protein LDOC1 is a protein that in humans is encoded by the LDOC1 gene.{{cite journal | vauthors = Nagasaki K, Manabe T, Hanzawa H, Maass N, Tsukada T, Yamaguchi K | title = Identification of a novel gene, LDOC1, down-regulated in cancer cell lines | journal = Cancer Letters | volume = 140 | issue = 1–2 | pages = 227–34 | date = Jun 1999 | pmid = 10403563 | doi = 10.1016/S0304-3835(99)00087-7 }}{{cite journal | vauthors = Brandt J, Schrauth S, Veith AM, Froschauer A, Haneke T, Schultheis C, Gessler M, Leimeister C, Volff JN | title = Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals | journal = Gene | volume = 345 | issue = 1 | pages = 101–11 | date = Jan 2005 | pmid = 15716091 | doi = 10.1016/j.gene.2004.11.022 }}{{cite journal | vauthors = Brandt J, Veith AM, Volff JN | title = A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes | journal = Cytogenetic and Genome Research | volume = 110 | issue = 1–4 | pages = 307–17 | date = Aug 2005 | pmid = 16093683 | doi = 10.1159/000084963 | s2cid = 38398479 }}{{cite web | title = Entrez Gene: LDOC1 leucine zipper, down-regulated in cancer 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23641}}

Function

The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.

Interactions

LDOC1 has been shown to interact with ABLIM1.{{cite journal|author-link30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}

References

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Further reading

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  • {{cite journal | vauthors = Nagasaki K, Schem C, von Kaisenberg C, Biallek M, Rösel F, Jonat W, Maass N | title = Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis | journal = International Journal of Cancer | volume = 105 | issue = 4 | pages = 454–8 | date = Jul 2003 | pmid = 12712434 | doi = 10.1002/ijc.11122 | doi-access = free }}
  • {{cite journal | vauthors = Chih DY, Park DJ, Gross M, Idos G, Vuong PT, Hirama T, Chumakov AM, Said J, Koeffler HP | title = Protein partners of C/EBPepsilon | journal = Experimental Hematology | volume = 32 | issue = 12 | pages = 1173–81 | date = Dec 2004 | pmid = 15588942 | doi = 10.1016/j.exphem.2004.08.014 | doi-access = free }}
  • {{cite journal | vauthors = Inoue M, Takahashi K, Niide O, Shibata M, Fukuzawa M, Ra C | title = LDOC1, a novel MZF-1-interacting protein, induces apoptosis | journal = FEBS Letters | volume = 579 | issue = 3 | pages = 604–8 | date = Jan 2005 | pmid = 15670815 | doi = 10.1016/j.febslet.2004.12.030 | doi-access = free }}
  • {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}

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