LEFTY2

Left-right determination factor 2 (Lefty2) aka TGFB4 is a protein that is encoded by the LEFTY2 gene in humans.

{{cite web

| title = Entrez Gene: Left-right determination factor 2

| url = https://www.ncbi.nlm.nih.gov/gene/7044

| access-date = 2016-04-19

}}

Function

Lefty2 is a protein from the TGF-beta cytokine family of proteins and is sometimes referred to as TGFB-4.{{Cite web |last=GeneCards Human Gene Database |title=LEFTY2 Gene - GeneCards {{!}} LFTY2 Protein {{!}} LFTY2 Antibody |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=LEFTY2 |archive-url=https://web.archive.org/web/20211215082321/https://www.genecards.org/cgi-bin/carddisp.pl?gene=LEFTY2 |archive-date=2021-12-15 |access-date=2025-04-03 |website=www.genecards.org |language=en}}{{Cite web |title=LEFTY2 left-right determination factor 2 [Homo sapiens (human)] - Gene - NCBI |url=https://www.ncbi.nlm.nih.gov/gene/7044 |access-date=2025-04-03 |website=www.ncbi.nlm.nih.gov}} It is secreted and plays a role in left-right asymmetry determination of organ systems during development. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs.

Lefty2 is also sometimes referred to as Endometrial Bleeding-Associated Factor (EBAF). Some types of infertility have been associated with dysregulated expression of this gene in the endometrium and the protein may play a role in endometrial bleeding.

Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

LEFTY2

Function

References

Further reading