LGR4
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene.{{cite journal |vauthors=Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, ((Kolakowski LF Jr)) | title = Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping | journal = Cytogenet Cell Genet | volume = 89 | issue = 1–2 | pages = 2–5 |date=Aug 2000 | pmid = 10894923 | doi =10.1159/000015576 | s2cid = 607389 }}{{cite web | title = Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55366}} LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.
Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).
References
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Further reading
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- {{cite journal |vauthors=Hsu SY, Liang SG, Hsueh AJ |title=Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region |journal=Mol. Endocrinol. |volume=12 |issue= 12 |pages= 1830–45 |year= 1999 |pmid= 9849958 |doi=10.1210/me.12.12.1830 |doi-access=free }}
- {{cite journal |vauthors=Loh ED, Broussard SR, Kolakowski LF |title=Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 3 |pages= 757–64 |year= 2001 |pmid= 11401528 |doi= 10.1006/bbrc.2001.4625 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
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{{G protein-coupled receptors}}
Category:G protein-coupled receptors
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