LHASA

{{about|the program that aids in total synthesis|the data compression program|Lhasa (computing)|other uses|Lhasa (disambiguation)}}

LHASA (Logic and Heuristics Applied to Synthetic Analysis) is a computer program developed in 1971 by the research group of Elias James Corey at the Harvard University Department of Chemistry. The program uses artificial intelligence techniques to discover sequences of reactions which may be used to synthesize a molecule.{{Cite journal |last=Corey |first=E. J. |last2=Wipke |first2=W. Todd |last3=Cramer |first3=Richard D. |last4=Howe |first4=W. Jeffrey |date=1972-01-01 |title=Computer-assisted synthetic analysis. Facile man-machine communication of chemical structure by interactive computer graphics |url=https://pubs.acs.org/doi/abs/10.1021/ja00757a020 |journal=Journal of the American Chemical Society |language=en |volume=94 |issue=2 |pages=421–430 |doi=10.1021/ja00757a020 |issn=0002-7863|url-access=subscription }} This program was one of the first to use a graphical interface to input and display chemical structures.{{Cite journal |last=Wang |first=Zhuang |last2=Zhang |first2=Wenhan |last3=Liu |first3=Bo |date=2021-06-26 |title=Computational Analysis of Synthetic Planning: Past and Future |url=https://onlinelibrary.wiley.com/doi/10.1002/cjoc.202100273 |journal=Chinese Journal of Chemistry |language=en |volume=39 |issue=11 |pages=3127–3143 |doi=10.1002/cjoc.202100273 |issn=1001-604X|url-access=subscription }}