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LHFPL2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Lipoma HMGIC fusion partner-like 2 protein is a protein that in humans is encoded by the LHFPL2 gene.{{cite journal |vauthors=Petit MM, Schoenmakers EF, Huysmans C, Geurts JM, Mandahl N, Van de Ven WJ | title = LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes | journal = Genomics | volume = 57 | issue = 3 | pages = 438–41 |date=Aug 1999 | pmid = 10329012 | doi = 10.1006/geno.1999.5778 }}{{cite web | title = Entrez Gene: LHFPL2 lipoma HMGIC fusion partner-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10184}}

This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

References

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Further reading

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  • {{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-style=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
  • {{cite journal | author=Longo-Guess CM |title=A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 22 |pages= 7894–9 |year= 2005 |pmid= 15905332 |doi= 10.1073/pnas.0500760102 | pmc=1142366 |name-list-style=vanc| author2=Gagnon LH | author3=Cook SA | display-authors=3 | last4=Wu | first4=J. | last5=Zheng | first5=Q. Y. | last6=Johnson | first6=K. R. |bibcode=2005PNAS..102.7894L |doi-access=free }}
  • {{cite journal | author=Brandenberger R |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |name-list-style=vanc| author2=Wei H | author3=Zhang S | display-authors=3 | last4=Lei | first4=Shirley | last5=Murage | first5=Jaji | last6=Fisk | first6=Gregory J | last7=Li | first7=Yan | last8=Xu | first8=Chunhui | last9=Fang | first9=Rixun |s2cid=27764390 }}
  • {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
  • {{cite journal | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=10.1093/dnares/3.5.321 |name-list-style=vanc| author2=Seki N | author3=Ishikawa K | display-authors=3 | last4=Ohira | first4=M | last5=Kawarabayasi | first5=Y | last6=Ohara | first6=O | last7=Tanaka | first7=A | last8=Kotani | first8=H | last9=Miyajima | first9=N | doi-access=free }}
  • {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}

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External links

  • {{UCSC genome browser|LHFPL2}}
  • {{UCSC gene details|LHFPL2}}

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