LHX3

LHX3 encodes a protein of a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.

Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine.

LHX3 has been shown to interact with Ldb1.{{cite journal |vauthors=Jurata LW, Pfaff SL, Gill GN | title = The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors | journal = J. Biol. Chem. | volume = 273 | issue = 6 | pages = 3152–7 |date=February 1998 | pmid = 9452425 | doi = 10.1074/jbc.273.6.3152 | doi-access = free }}

{{reflist}}

{{refbegin | 2}}

• {{cite journal | author=Zhadanov AB |title=Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues |journal=Dev. Dyn. |volume=202 |issue= 4 |pages= 354–64 |year= 1995 |pmid= 7626792 |doi= 10.1002/aja.1002020405 | author2=Bertuzzi S | author3=Taira M | last4=Dawid | first4=Igor B. | last5=Westphal | first5=Heiner |s2cid=36677316 }}
• {{cite journal | author=Zhadanov AB |title=Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3 |journal=Genomics |volume=27 |issue= 1 |pages= 27–32 |year= 1995 |pmid= 7665181 |doi= 10.1006/geno.1995.1004 | author2=Copeland NG | author3=Gilbert DJ | last4=Jenkins | first4=Nancy A. | last5=Westphal | first5=Heiner |url=https://zenodo.org/record/1229689 }}
• {{cite journal |vauthors=Jurata LW, Pfaff SL, Gill GN |title=The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3152–7 |year= 1998 |pmid= 9452425 |doi=10.1074/jbc.273.6.3152 |doi-access=free }}
• {{cite journal | author=Bach I |title=RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex |journal=Nat. Genet. |volume=22 |issue= 4 |pages= 394–9 |year= 1999 |pmid= 10431247 |doi= 10.1038/11970 | author2=Rodriguez-Esteban C | author3=Carrière C | last4=Rodriguez-Esteban | first4=Concepción | last5=Carrière | first5=Catherine | last6=Bhushan | first6=Anil | last7=Krones | first7=Anna | last8=Rose | first8=David W. | last9=Glass | first9=Christopher K. |s2cid=22326394 }}
• {{cite journal |vauthors=Glenn DJ, Maurer RA |title=MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36159–67 |year= 2000 |pmid= 10593900 |doi=10.1074/jbc.274.51.36159 |doi-access=free }}
• {{cite journal |vauthors=Howard PW, Maurer RA |title=Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13336–42 |year= 2000 |pmid= 10788441 |doi=10.1074/jbc.275.18.13336 |doi-access= free}}
• {{cite journal | author=Parker GE |title=The homeodomain coordinates nuclear entry of the Lhx3 neuroendocrine transcription factor and association with the nuclear matrix |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23891–8 |year= 2000 |pmid= 10818088 |doi= 10.1074/jbc.M000377200 | author2=Sandoval RM | author3=Feister HA | last4=Bidwell | first4=JP | last5=Rhodes | first5=SJ |doi-access=free }}
• {{cite journal | author=Netchine I |title=Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency |journal=Nat. Genet. |volume=25 |issue= 2 |pages= 182–6 |year= 2000 |pmid= 10835633 |doi= 10.1038/76041 | author2=Sobrier ML | author3=Krude H | last4=Krude | first4=Heiko | last5=Schnabel | first5=Dirk | last6=Maghnie | first6=Mohamed | last7=Marcos | first7=Elisabeth | last8=Duriez | first8=Bénédicte | last9=Cacheux | first9=Valère |s2cid=12358307 }}
• {{cite journal |vauthors=Schmitt S, Biason-Lauber A, Betts D, Schoenle EJ |title=Genomic structure, chromosomal localization, and expression pattern of the human LIM-homeobox3 (LHX 3) gene |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 1 |pages= 49–56 |year= 2000 |pmid= 10903894 |doi= 10.1006/bbrc.2000.3038 }}
• {{cite journal |vauthors=Sloop KW, Dwyer CJ, Rhodes SJ |title=An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36311–9 |year= 2001 |pmid= 11470784 |doi= 10.1074/jbc.M103888200 |doi-access= free }}
• {{cite journal | author=Ostendorff HP |title=Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors |journal=Nature |volume=416 |issue= 6876 |pages= 99–103 |year= 2002 |pmid= 11882901 |doi= 10.1038/416099a | author2=Peirano RI | author3=Peters MA | last4=Schlüter | first4=Anne | last5=Bossenz | first5=Michael | last6=Scheffner | first6=Martin | last7=Bach | first7=Ingolf |bibcode=2002Natur.416...99O |s2cid=4426785 }}
• {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal |vauthors=van Meyel DJ, Thomas JB, Agulnick AD |title=Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo |journal=Development |volume=130 |issue= 9 |pages= 1915–25 |year= 2003 |pmid= 12642495 |doi=10.1242/dev.00389 |s2cid=6211268 |doi-access= }}
• {{cite journal | author=Kim SS |title=Clinical characteristics and molecular analysis of PIT1, PROP1, LHX3, and HESX1 in combined pituitary hormone deficiency patients with abnormal pituitary MR imaging |journal=Horm. Res. |volume=60 |issue= 6 |pages= 277–83 |year= 2004 |pmid= 14646405 |doi= 10.1159/000074245 | author2=Kim Y | author3=Shin YL | last4=Kim | first4=Gu-Hwan | last5=Kim | first5=Tae-Ue | last6=Yoo | first6=Han-Wook |s2cid=31256955 }}
• {{cite journal | author=Dattani MT |title=Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene |journal=J. Pediatr. Endocrinol. Metab. |volume=16 |issue= 9 |pages= 1207–9 |year= 2004 |pmid= 14714741 |doi= 10.1515/jpem.2003.16.9.1207|s2cid=45542882 }}
• {{cite journal | author=West BE |title=Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor |journal=Endocrinology |volume=145 |issue= 11 |pages= 4866–79 |year= 2004 |pmid= 15271874 |doi= 10.1210/en.2004-0598 | author2=Parker GE | author3=Savage JJ | last4=Kiratipranon | first4=P | last5=Toomey | first5=KS | last6=Beach | first6=LR | last7=Colvin | first7=SC | last8=Sloop | first8=KW | last9=Rhodes | first9=SJ | doi-access=free }}
• {{cite journal |vauthors=Parker GE, West BE, Witzmann FA, Rhodes SJ |title=Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor |journal=J. Cell. Biochem. |volume=94 |issue= 1 |pages= 67–80 |year= 2005 |pmid= 15517599 |doi= 10.1002/jcb.20287 |s2cid=41303062 }}
• {{cite journal | author=Sobrier ML |title=Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development |journal=Gene Expr. Patterns |volume=5 |issue= 2 |pages= 279–84 |year= 2006 |pmid= 15567726 |doi= 10.1016/j.modgep.2004.07.003 | author2=Attié-Bitach T | author3=Netchine I | last4=Encha-Razavi | first4=F. | last5=Vekemans | first5=M. | last6=Amselem | first6=S. }}

{{refend}}

• {{MeshName|LHX3+protein,+human}}

{{NLM content}}

{{Transcription factors}}

Category:Transcription factors

{{gene-9-stub}}