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LILRB3

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.{{cite journal |vauthors=Arm JP, Nwankwo C, Austen KF | title = Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor | journal = J Immunol | volume = 159 | issue = 5 | pages = 2342–9 |date=Sep 1997 | doi = 10.4049/jimmunol.159.5.2342 | pmid = 9278324 }}{{cite journal |vauthors=Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, Lopez-Botet M | title = A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells | journal = J Exp Med | volume = 186 | issue = 11 | pages = 1809–18 |date=Dec 1997 | pmid = 9382880 | pmc = 2199153 | doi =10.1084/jem.186.11.1809 }}{{cite web | title = Entrez Gene: LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11025}}

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells and is believed to be a myeloid checkpoint. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.{{cite web | title = Entrez Gene: LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11025}}

See also

References

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Further reading

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  • {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
  • {{cite journal |vauthors=Sloane DE, Tedla N, Awoniyi M, etal |title=Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. |journal=Blood |volume=104 |issue= 9 |pages= 2832–9 |year= 2004 |pmid= 15242876 |doi= 10.1182/blood-2004-01-0268 |doi-access= }}
  • {{cite journal |vauthors=Tedla N, Bandeira-Melo C, Tassinari P, etal |title=Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 3 |pages= 1174–9 |year= 2003 |pmid= 12529506 |doi= 10.1073/pnas.0337567100 | pmc=298746 |bibcode=2003PNAS..100.1174T |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Wende H, Volz A, Ziegler A |title=Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. |journal=Immunogenetics |volume=51 |issue= 8–9 |pages= 703–13 |year= 2000 |pmid= 10941842 |doi=10.1007/s002510000187 |s2cid=20719684 }}
  • {{cite journal |vauthors=Borges L, Hsu ML, Fanger N, etal |title=A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. |journal=J. Immunol. |volume=159 |issue= 11 |pages= 5192–6 |year= 1998 |doi=10.4049/jimmunol.159.11.5192 |pmid= 9548455 }}
  • {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal |vauthors=Cella M, Döhring C, Samaridis J, etal |title=A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. |journal=J. Exp. Med. |volume=185 |issue= 10 |pages= 1743–51 |year= 1997 |pmid= 9151699 |doi=10.1084/jem.185.10.1743 | pmc=2196312 }}
  • {{cite journal |vauthors=Samaridis J, Colonna M |title=Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. |journal=Eur. J. Immunol. |volume=27 |issue= 3 |pages= 660–5 |year= 1997 |pmid= 9079806 |doi=10.1002/eji.1830270313 |s2cid=2212182 |doi-access=free }}
  • {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}

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External links

  • {{MeshName|LILRB3+protein,+human}}

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Category:Clusters of differentiation

Category:Immunoglobulin superfamily

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