LLGL1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{cs1 config|name-list-style=vanc}}
{{Infobox_gene}}
Lethal(2) giant larvae protein homolog 1 is a protein that in humans is encoded by the LLGL1 gene.{{cite journal |vauthors=Strand D, Unger S, Corvi R, Hartenstein K, Schenkel H, Kalmes A, Merdes G, Neumann B, Krieg-Schneider F, Coy JF | title = A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain | journal = Oncogene | volume = 11 | issue = 2 | pages = 291–301 |date=Aug 1995 | pmid = 7542763 |display-authors=etal}}{{cite journal |vauthors=Koyama K, Fukushima Y, Inazawa J, Tomotsune D, Takahashi N, Nakamura Y | title = The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2 | journal = Cytogenet Cell Genet | volume = 72 | issue = 1 | pages = 78–82 |date=Mar 1996 | pmid = 8565641 | doi =10.1159/000134167 }}
This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17.{{cite web | title = Entrez Gene: LLGL1 lethal giant larvae homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3996}}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Campbell HD, Fountain S, Young IG, etal |title=Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL. |journal=Genomics |volume=42 |issue= 1 |pages= 46–54 |year= 1997 |pmid= 9177775 |doi= 10.1006/geno.1997.4709 }}
- {{cite journal |vauthors=Ludford-Menting MJ, Thomas SJ, Crimeen B, etal |title=A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 4477–84 |year= 2002 |pmid= 11714708 |doi= 10.1074/jbc.M108479200 |doi-access= free }}
- {{cite journal |vauthors=Bi W, Yan J, Stankiewicz P, etal |title=Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse |journal=Genome Res. |volume=12 |issue= 5 |pages= 713–28 |year= 2002 |pmid= 11997338 |doi= 10.1101/gr.73702 | pmc=186594 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Yamanaka T, Horikoshi Y, Sugiyama Y, etal |title=Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity |journal=Curr. Biol. |volume=13 |issue= 9 |pages= 734–43 |year= 2004 |pmid= 12725730 |doi=10.1016/S0960-9822(03)00244-6 |s2cid=18570360 |doi-access=free }}
- {{cite journal |vauthors=Grifoni D, Garoia F, Schimanski CC, etal |title=The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo |journal=Oncogene |volume=23 |issue= 53 |pages= 8688–94 |year= 2004 |pmid= 15467749 |doi= 10.1038/sj.onc.1208023 |doi-access= |s2cid=23322807 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Schimanski CC, Schmitz G, Kashyap A, etal |title=Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer |journal=Oncogene |volume=24 |issue= 19 |pages= 3100–9 |year= 2005 |pmid= 15735678 |doi= 10.1038/sj.onc.1208520 |doi-access= free }}
- {{cite journal |vauthors=Kuphal S, Wallner S, Schimanski CC, etal |title=Expression of Hugl-1 is strongly reduced in malignant melanoma |journal=Oncogene |volume=25 |issue= 1 |pages= 103–10 |year= 2006 |pmid= 16170365 |doi= 10.1038/sj.onc.1209008 |doi-access= |s2cid=9808205 }}
- {{cite journal |vauthors=Grifoni D, Garoia F, Bellosta P, etal |title=aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia |journal=Oncogene |volume=26 |issue= 40 |pages= 5960–5 |year= 2007 |pmid= 17369850 |doi= 10.1038/sj.onc.1210389 |doi-access= |s2cid=12965688 }}
{{refend}}
{{gene-17-stub}}