Login
Login

LMOD3

{{short description|Protein-coding gene in humans}}

{{Infobox_gene}}

Leiomodin-3 is a protein that in humans is encoded by the LMOD3 gene.{{cite web | title = Entrez Gene: LMOD3 leiomodin 3 (fetal) | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56203 }} Leiomodin-3 is especially present at the pointed end of muscle thin filaments.{{cite journal | vauthors = Nowak KJ, Davis MR, Wallgren-Pettersson C, Lamont PJ, Laing NG | title = Clinical utility gene card for: Nemaline myopathy - update 2015 | journal = European Journal of Human Genetics | volume = 23 | issue = 11 | pages = 4–5 | date = November 2015 | pmid = 25712079 | doi = 10.1038/ejhg.2015.12 | pmc = 4613474 }}

Clinical significance

Dysfunction is associated with thin filament disorganisation and nemaline myopathy.

References

{{Reflist|30em|refs=

{{cite journal | vauthors = Gunning PW, Ghoshdastider U, Whitaker S, Popp D, Robinson RC | title = The evolution of compositionally and functionally distinct actin filaments | journal = Journal of Cell Science | volume = 128 | issue = 11 | pages = 2009–19 | date = June 2015 | pmid = 25788699 | doi = 10.1242/jcs.165563 | doi-access = free }}

{{cite journal | vauthors = Yuen M, Sandaradura SA, Dowling JJ, Kostyukova AS, Moroz N, Quinlan KG, Lehtokari VL, Ravenscroft G, Todd EJ, Ceyhan-Birsoy O, Gokhin DS, Maluenda J, Lek M, Nolent F, Pappas CT, Novak SM, D'Amico A, Malfatti E, Thomas BP, Gabriel SB, Gupta N, Daly MJ, Ilkovski B, Houweling PJ, Davidson AE, Swanson LC, Brownstein CA, Gupta VA, Medne L, Shannon P, Martin N, Bick DP, Flisberg A, Holmberg E, Van den Bergh P, Lapunzina P, Waddell LB, Sloboda DD, Bertini E, Chitayat D, Telfer WR, Laquerrière A, Gregorio CC, Ottenheijm CA, Bönnemann CG, Pelin K, Beggs AH, Hayashi YK, Romero NB, Laing NG, Nishino I, Wallgren-Pettersson C, Melki J, Fowler VM, MacArthur DG, North KN, Clarke NF | display-authors = 6 | title = Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy | journal = The Journal of Clinical Investigation | volume = 124 | issue = 11 | pages = 4693–708 | date = November 2014 | pmid = 25250574 | pmc = 4347224 | doi = 10.1172/JCI75199 }}

}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors = Lane HY, Liu YC, Huang CL, Chang YC, Wu PL, Lu CT, Chang WH | title = Risperidone-related weight gain: genetic and nongenetic predictors | journal = Journal of Clinical Psychopharmacology | volume = 26 | issue = 2 | pages = 128–34 | date = April 2006 | pmid = 16633140 | doi = 10.1097/01.jcp.0000203196.65710.2b | s2cid = 34821033 }}
  • {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = January 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
  • {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
  • {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = September 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
  • {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = March 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
  • {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = November 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}

{{refend}}

{{gene-3-stub}}