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LRIG1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene.{{cite journal |vauthors=Nilsson J, Vallbo C, Guo D, Golovleva I, Hallberg B, Henriksson R, Hedman H | title = Cloning, characterization, and expression of human LIG1 | journal = Biochem Biophys Res Commun | volume = 284 | issue = 5 | pages = 1155–61 |date=Jun 2001 | pmid = 11414704 | doi = 10.1006/bbrc.2001.5092 }}{{cite journal |vauthors=Hedman H, Nilsson J, Guo D, Henriksson R | title = Is LRIG1 a tumour suppressor gene at chromosome 3p14.3? | journal = Acta Oncol | volume = 41 | issue = 4 | pages = 352–4 |date=Sep 2002 | pmid = 12234026 | doi =10.1080/028418602760169398 | s2cid = 34357648 }}{{cite web | title = Entrez Gene: LRIG1 leucine-rich repeats and immunoglobulin-like domains 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26018}}

It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR family{{cite journal | author=Gur G |title=LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation |journal=EMBO J. |volume=23 |issue= 16 |pages= 3270–81 |year= 2005 |pmid= 15282549 |doi= 10.1038/sj.emboj.7600342 | pmc=514515 |name-list-style=vanc| author2=Rubin C | author3=Katz M | display-authors=3 | last4=Amit | first4=Ido | last5=Citri | first5=Ami | last6=Nilsson | first6=Jonas | last7=Amariglio | first7=Ninette | last8=Henriksson | first8=Roger | last9=Rechavi | first9=Gideon }}

and with MET{{cite journal | author=Shattuck DL |title=LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy |journal=Mol. Cell. Biol. |volume=27 |issue= 5 |pages= 1934–46 |year= 2007 |pmid= 17178829 |doi= 10.1128/MCB.00757-06 | pmc=1820466 |name-list-style=vanc| author2=Miller JK | author3=Laederich M | display-authors=3 | last4=Funes | first4=M. | last5=Petersen | first5=H. | last6=Carraway | first6=K. L. | last7=Sweeney | first7=C. }} and RET.{{cite journal |vauthors=Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G |title=Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF |journal= J. Neurosci. |volume=28 |issue= 2 |pages= 39–49 |year= 2008 |pmid= 18171921 |doi=10.1523/JNEUROSCI.2196-07.2008 |pmc=6671136 |doi-access= free }}

References

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Further reading

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  • {{cite journal | author=Suzuki Y |title=cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains |journal=J. Biol. Chem. |volume=271 |issue= 37 |pages= 22522–7 |year= 1996 |pmid= 8798419 |doi=10.1074/jbc.271.37.22522 |name-list-style=vanc| author2=Sato N | author3=Tohyama M | display-authors=3 | last4=Wanaka | first4=A | last5=Takagi | first5=T |doi-access=free}}
  • {{cite journal | author=Suzuki Y |title=Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia |journal=FEBS Lett. |volume=521 |issue= 1–3 |pages= 67–71 |year= 2002 |pmid= 12067728 |doi=10.1016/S0014-5793(02)02824-7 |name-list-style=vanc| author2=Miura H | author3=Tanemura A | display-authors=3 | last4=Kobayashi | first4=K | last5=Kondoh | first5=G | last6=Sano | first6=S | last7=Ozawa | first7=K | last8=Inui | first8=S | last9=Nakata | first9=A |s2cid=5634836 | doi-access=free }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Nilsson J, Starefeldt A, Henriksson R, Hedman H |title=LRIG1 protein in human cells and tissues |journal=Cell Tissue Res. |volume=312 |issue= 1 |pages= 65–71 |year= 2004 |pmid= 12684867 |doi= 10.1007/s00441-003-0697-1 |s2cid=7060595 }}
  • {{cite journal | author=Thomasson M |title=LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT–PCR and immunohistochemical analysis |journal=Br. J. Cancer |volume=89 |issue= 7 |pages= 1285–9 |year= 2003 |pmid= 14520461 |doi= 10.1038/sj.bjc.6601208 | pmc=2394322 |name-list-style=vanc| author2=Hedman H | author3=Guo D | display-authors=3 | last4=Ljungberg | first4=B | last5=Henriksson | first5=R }}
  • {{cite journal | author=Gur G |title=LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation |journal=EMBO J. |volume=23 |issue= 16 |pages= 3270–81 |year= 2005 |pmid= 15282549 |doi= 10.1038/sj.emboj.7600342 | pmc=514515 |name-list-style=vanc| author2=Rubin C | author3=Katz M | display-authors=3 | last4=Amit | first4=Ido | last5=Citri | first5=Ami | last6=Nilsson | first6=Jonas | last7=Amariglio | first7=Ninette | last8=Henriksson | first8=Roger | last9=Rechavi | first9=Gideon }}
  • {{cite journal | author=Laederich MB |title=The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47050–6 |year= 2004 |pmid= 15345710 |doi= 10.1074/jbc.M409703200 |name-list-style=vanc| author2=Funes-Duran M | author3=Yen L | display-authors=3 | last4=Ingalla | first4=E | last5=Wu | first5=X | last6=Carraway Kl | first6=3rd | last7=Sweeney | first7=C | doi-access=free }}
  • {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
  • {{cite journal | author=Ljuslinder I |title=Increased copy number at 3p14 in breast cancer |journal=Breast Cancer Res. |volume=7 |issue= 5 |pages= R719–27 |year= 2006 |pmid= 16168117 |doi= 10.1186/bcr1279 | pmc=1242137 |name-list-style=vanc| author2=Malmer B | author3=Golovleva I | display-authors=3 | last4=Thomasson | first4=Marcus | last5=Grankvist | first5=Kjell | last6=Höckenström | first6=Thomas | last7=Emdin | first7=Stefan | last8=Jonsson | first8=Yvonne | last9=Hedman | first9=Håkan |doi-access=free }}
  • {{cite journal |vauthors=Jensen KB, Watt FM |title=Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 32 |pages= 11958–63 |year= 2006 |pmid= 16877544 |doi= 10.1073/pnas.0601886103 | pmc=1567680 |bibcode=2006PNAS..10311958J |doi-access=free }}
  • {{cite journal | author=Shattuck DL |title=LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy |journal=Mol. Cell. Biol. |volume=27 |issue= 5 |pages= 1934–46 |year= 2007 |pmid= 17178829 |doi= 10.1128/MCB.00757-06 | pmc=1820466 |name-list-style=vanc| author2=Miller JK | author3=Laederich M | display-authors=3 | last4=Funes | first4=M. | last5=Petersen | first5=H. | last6=Carraway | first6=K. L. | last7=Sweeney | first7=C. }}

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Category:Genes mutated in mice