LSE

• London School of Economics, a public research university within the University of London
• Lahore School of Economics, a private university in Lahore, Punjab, Pakistan
• Lincoln Southeast High School, a public government education school located in Lincoln, Nebraska
• Louvain School of Engineering, faculty of engineering science at the University of Louvain (UCLouvain), Belgium

• {{lang|fr|Langage symbolique d'enseignement}} ("Symbolic teaching language"), a computer programming language
• Language-Sensitive Editor, a text editor used on Digital Equipment Corporation's VMS operating system
• Large system extensions, a set of atomic memory operations such as fetch-and-add for the 64-bit ARM (AArch64) architecture
• Latent sector error, an unrecoverable read error on a hard disk drive which has not yet been discovered

• Lahore Stock Exchange, now Pakistan Stock Exchange
• London Stock Exchange
• London Stock Exchange Group, the owner group of the London Stock Exchange

• La Crosse Regional Airport, Wisconsin, United States (IATA code LSE)
• La Crosse station - Amtrak code LSE
• Luzern–Stans–Engelberg railway line, a mountain railway in Switzerland

• Load serving entity, an electricity demand aggregator in the deregulated market.
• Landing ship, Emergency Repair, a US WW2 Navy ship
• Least-squares estimation, a statistical technique commonly used in data fitting
• Lengua de signos española, Spanish Sign Language
• Logical Sensory Extrovert, a socionics personality type

{{Disambiguation|school}}