LSM5

{{Short description|Protein-coding gene in the species Homo sapiens}}

U6 snRNA-associated Sm-like protein LSm5 is a protein that in humans is encoded by the LSM5 gene.{{cite journal |vauthors=Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B | title = Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin | journal = EMBO J | volume = 18 | issue = 12 | pages = 3451–62 |date=Aug 1999 | pmid = 10369684 | pmc = 1171424 | doi = 10.1093/emboj/18.12.3451 }}{{cite journal |vauthors=Ingelfinger D, Arndt-Jovin DJ, Luhrmann R, Achsel T | title = The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci | journal = RNA | volume = 8 | issue = 12 | pages = 1489–501 |date=Jan 2003 | pmid = 12515382 | pmc = 1370355 | doi = 10.1017/S1355838202021726}}{{cite web | title = Entrez Gene: LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23658}}

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]

References

{{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-style=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
{{cite journal |vauthors=Lehner B, Sanderson CM |title=A Protein Interaction Framework for Human mRNA Degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
{{cite journal | author=Scherer SW |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 |name-list-style=vanc| author2=Cheung J | author3=MacDonald JR | display-authors=3 | last4=Osborne | first4=LR | last5=Nakabayashi | first5=K | last6=Herbrick | first6=JA | last7=Carson | first7=AR | last8=Parker-Katiraee | first8=L | last9=Skaug | first9=J |bibcode=2003Sci...300..767S }}
{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal | author=Eystathioy T |title=Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera |journal=Arthritis Rheum. |volume=46 |issue= 3 |pages= 726–34 |year= 2002 |pmid= 11920408 |doi= 10.1002/art.10220 |name-list-style=vanc| author2=Peebles CL | author3=Hamel JC | display-authors=3 | last4=Vaughn | first4=John H. | last5=Chan | first5=Edward K. L. |doi-access=free }}
{{cite journal | author=Suzuki H |title=Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 | pmc=311163 |name-list-style=vanc| author2=Fukunishi Y | author3=Kagawa I | display-authors=3 | last4=Saito | first4=R | last5=Oda | first5=H | last6=Endo | first6=T | last7=Kondo | first7=S | last8=Bono | first8=H | last9=Okazaki | first9=Y }}
{{cite journal |vauthors=Friesen WJ, Dreyfuss G |title=Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN) |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26370–5 |year= 2000 |pmid= 10851237 |doi= 10.1074/jbc.M003299200 |doi-access= free }}
{{cite journal | author=Achsel T |title=A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro |journal=EMBO J. |volume=18 |issue= 20 |pages= 5789–802 |year= 1999 |pmid= 10523320 |doi= 10.1093/emboj/18.20.5789 | pmc=1171645 |name-list-style=vanc| author2=Brahms H | author3=Kastner B | display-authors=3 | last4=Bachi | first4=A | last5=Wilm | first5=M | last6=Lührmann | first6=R }}

LSM5

References

Further reading