LYPLA1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Acyl-protein thioesterase 1 is an enzyme that in humans is encoded by the LYPLA1 gene.{{cite journal |vauthors=Wang A, Yang HC, Friedman P, Johnson CA, Dennis EA | title = A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization | journal = Biochim Biophys Acta | volume = 1437 | issue = 2 | pages = 157–69 |date=Apr 1999 | pmid = 10064899 | doi = 10.1016/s1388-1981(99)00012-8}}{{cite web | title = Entrez Gene: LYPLA1 lysophospholipase I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10434}}
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.
References
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Further reading
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- {{cite journal |vauthors=Wang A, Dennis EA |title=Mammalian lysophospholipases. |journal=Biochim. Biophys. Acta |volume=1439 |issue= 1 |pages= 1–16 |year= 1999 |pmid= 10395961 |doi= 10.1016/s1388-1981(99)00063-3}}
- {{cite journal |vauthors=Bohn E, Gerke V, Kresse H, etal |title=Annexin II inhibits calcium-dependent phospholipase A1 and lysophospholipase but not triacyl glycerol lipase activities of rat liver hepatic lipase. |journal=FEBS Lett. |volume=296 |issue= 3 |pages= 237–40 |year= 1992 |pmid= 1531641 |doi=10.1016/0014-5793(92)80294-Q |s2cid=19633878 |doi-access=free }}
- {{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
- {{cite journal |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
- {{cite journal |vauthors=Wang A, Johnson CA, Jones Y, etal |title=Subcellular localization and PKC-dependent regulation of the human lysophospholipase A/acyl-protein thioesterase in WISH cells. |journal=Biochim. Biophys. Acta |volume=1484 |issue= 2–3 |pages= 207–14 |year= 2000 |pmid= 10760470 |doi= 10.1016/s1388-1981(00)00020-2|s2cid=24130546 }}
- {{cite journal |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 }}
- {{cite journal |vauthors=Devedjiev Y, Dauter Z, Kuznetsov SR, etal |title=Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A. |journal=Structure |volume=8 |issue= 11 |pages= 1137–46 |year= 2001 |pmid= 11080636 |doi=10.1016/S0969-2126(00)00529-3 |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
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