Laura L. Kiessling

{{BLP unsourced section|date=June 2021}}

Kiessling earned a B.S. in chemistry from the Massachusetts Institute of Technology in 1983 and a Ph.D. in chemistry from Yale University in 1989.{{cite web |title=Laura L. Kiessling |url=https://www.macfound.org/fellows/class-of-1999/laura-l-kiessling |website=MacArthur Foundation |access-date=16 March 2022}} At Yale, she worked with Stuart Schreiber to synthesize and study small molecules as probes of biological function. After earning her PhD, Kiessling spent two years at the California Institute of Technology as an American Cancer Society Postdoctoral Fellow, where she worked with Peter B. Dervan to study DNA recognition and cleavage.

In 1991, Kiessling joined the faculty of the University of Wisconsin–Madison,{{cite news|url=http://chicagoacs.org/images/downloads/Chemical_Bulletin/2016_05_chembulletin.pdf|title=THE ONE HUNDRED AND FIFTH PRESENTATION OF THE WILLARD GIBBS MEDAL (FOUNDED BY WILLIAM A. CONVERSE) TO PROFESSOR LAURA KIESSLING SPONSORED BY THE CHICAGO SECTION OF THE AMERICAN CHEMICAL SOCIETY FRIDAY, MAY 20, 2016|date=May 20, 2016|work=The Chemical Bulletin|accessdate=14 June 2017}} where she became the Steenbock Professor of Chemistry and the Laurens Anderson Professor of Biochemistry. While at UW-Madison, Kiessling also became the director of the Keck Center for Chemical Genomics{{Cite web|url=https://news.wisc.edu/foundation-supports-chemical-genomics-center/|title=Foundation supports chemical genomics center|website=news.wisc.edu|language=en-US|access-date=2018-08-01}} and the National Institutes of Health Chemistry-Biology Interface Training Program.{{Cite journal|url=http://grantome.com/grant/NIH/T32-GM008505-22|title=Chemistry-Biology Interface Training Program|journal=Grantome|access-date=2018-08-01|last1=Kiessling|first1=Laura}} In 2017, she moved to the Massachusetts Institute of Technology as the Novartis Professor of Chemistry.{{Cite web|url=http://kiesslinglab.com/laurakiessling/|title=Laura L. Kiessling – Kiessling Lab|website=kiesslinglab.com|date=17 March 2018 |language=en-US|access-date=2018-07-31}} as well as the editor-in-chief of ACS Chemical Biology.{{cite web|url=http://www.uwalumni.com/home/alumniandfriends/onwisconsin/archives/2001spring/keck.aspx|title=Wisconsin Alumni Association|archiveurl=https://web.archive.org/web/20120702224958/http://www.uwalumni.com/home/alumniandfriends/onwisconsin/archives/2001spring/keck.aspx|archivedate=July 2, 2012|url-status=dead|accessdate=July 18, 2012}}{{cite web|url=http://publications.nigms.nih.gov/multimedia/map/cbi/|title=Chemistry-Biology Interface Research Training Program Institutions|date=2015-12-09|website=Publications.nigms.nih.gov|accessdate=2016-07-02}}{{cite web|url=http://pubs.acs.org/journal/acbcct|title=ACS Chemical Biology|editor=Laura L. Kiessling|website=Pubs.acs.org|format=PDF|accessdate=2016-07-02}}

Kiessling's contributions span the fields of organic synthesis, polymer chemistry, and molecular biology. She has made contributions to the synthesis and study of many biologically active molecules, including glycosyl donors,{{Cite journal|last1=Hinklin|first1=Ronald|last2=Kiessling|first2=Laura|date=2001|title=Glycosyl Sulfonylcarbamates: New Glycosyl Donors with Tunable Reactivity|journal=Journal of the American Chemical Society|volume=123|issue=14|pages=3379–3380|doi=10.1021/ja005735i|pmid=11457079|s2cid=37296866}} modified peptides,{{Cite journal|last1=He|first1=Ye|last2=Hinklin|first2=Ronald|last3=Chang|first3=Jiyoung|last4=Kiessling|first4=Laura|date=2004|title=Stereoselective N-Glycosylation by Staudinger Ligation|journal=Organic Letters|volume=6|issue=24|pages=4479–4482|doi=10.1021/ol048271s|pmid=15548055|s2cid=12143159}}{{Cite journal|last1=Young|first1=Travis|last2=Kiessling|first2=Laura|date=2002|title=A Strategy for the Synthesis of Sulfated Peptides|journal=Angewandte Chemie|volume=41|issue=18|pages=3449–3451|doi=10.1002/1521-3773(20020916)41:18<3449::AID-ANIE3449>3.0.CO;2-U|pmid=12298060|s2cid=1683738}} and glycopolymers.{{Cite journal|last1=Strong|first1=Laura|last2=Kiessling|first2=Laura|date=1999|title=A General Synthetic Route to Defined, Biologically Active Multivalent Arrays|journal=Journal of the American Chemical Society|volume=121|issue=26|pages=6193–6196|doi=10.1021/ja990223t|s2cid=16075014}}{{Cite journal|last1=Pontrello|first1=Jason|last2=Allen|first2=Matthew|last3=Underbakke|first3=Eric|last4=Kiessling|first4=Laura|date=2005|title=Solid-Phase Synthesis of Polymers Using the Ring-Opening Metathesis Polymerization|journal=Journal of the American Chemical Society|volume=127|issue=42|pages=14536–14537|doi=10.1021/ja053931p|pmid=16231882|s2cid=744172}}{{Cite journal|last1=May|first1=John|last2=Splain|first2=Rebecca|last3=Brotschi|first3=Christine|last4=Kiessling|first4=Laura|date=2009|title=A tethering mechanism for length control in a processive carbohydrate polymerization|journal=Proceedings of the National Academy of Sciences|volume=106|issue=29|pages=11851–11865|doi=10.1073/pnas.0901407106|pmid=19571009|pmc=2715488|bibcode=2009PNAS..10611851M|doi-access=free}} Kiessling's research has used these molecules to probe cell recognition and signal transduction processes (Figure 1).{{Cite web|url=http://chemistry.mit.edu/multivalent-carbohydrates-new-and-powerful-probes-signal-transduction|title=Multivalent Carbohydrates As New and Powerful Probes of Signal Transduction {{!}} MIT Department of Chemistry|website=chemistry.mit.edu|language=en|access-date=2018-08-22}} Her research has shown that multivalent ligands (molecules that possess multiple binding groups) can influence receptor-ligand binding mechanisms,{{Cite journal|last1=Gestwicki|first1=Jason|last2=Cairo|first2=Christopher|last3=Strong|first3=Laura|last4=Oetjen|first4=Karolyn|last5=Kiessling|first5=Laura|date=2002|title=Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture|journal=Journal of the American Chemical Society|volume=124|issue=50|pages=14922–14933|doi=10.1021/ja027184x|pmid=12475334|s2cid=1492819}} activate signaling,{{Cite journal|last1=Gestwicki|first1=Jason|last2=Kiessling|first2=Laura|date=2002|title=Inter-receptor communication through arrays of bacterial chemoreceptors|journal=Nature|volume=415|issue=6867|pages=81–84|doi=10.1038/415081a|pmid=11780121|bibcode=2002Natur.415...81G|s2cid=4401992}} and target specific immune responses.{{Cite journal|last1=Courtney|first1=Adam|last2=Puffer|first2=Erik|last3=Pontrello|first3=Jason|last4=Yang|first4=Zhi-Qiang|last5=Kiessling|first5=Laura|date=2009|title=Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation|journal=Proceedings of the National Academy of Sciences|volume=106|issue=8|pages=2500–2505|doi=10.1073/pnas.0807207106|pmid=19202057|pmc=2650292|bibcode=2009PNAS..106.2500C|doi-access=free}} These discoveries have potential applications in targeted immunotherapy and disease treatment.{{Cite web|url=https://www.nsf.gov/news/news_summ.jsp?cntn_id=100382&org=OMA|title=Researchers Open New Line of Attack on Tuberculosis {{!}} NSF - National Science Foundation|website=www.nsf.gov|language=en|access-date=2018-08-22}}{{Cite journal|last1=Carlson|first1=Coby|last2=Mowery|first2=Patricia|last3=Owen|first3=Robert|last4=Dykhuizen|first4=Emily|last5=Kiessling|first5=Laura|date=2007|title=Selective Tumor Cell Targeting Using Low-Affinity, Multivalent Interactions|journal=ACS Chemical Biology|volume=2|issue=2|pages=119–127|doi=10.1021/cb6003788|pmid=17291050|citeseerx=10.1.1.590.9531}} File:Laura_Kiessling_research_-_glycopolymers_and_cell_signaling.tifs are synthesized by ring-opening metathesis polymerization. (B) Cell signaling can be mediated by protein-carbohydrate binding. (C) Kiessling's research uses synthetic mimics to study and manipulate the recognition and signal transduction pathways.]]Kiessling has received a number of awards and honors in recognition of her research. She received a MacArthur Foundation Fellowship (popularly called the "MacArthur genius grant") in 1999.{{cite web|url=http://www.macfound.org/fellows/search/?name=kiessling|title=MacArthur Fellows Program — MacArthur Foundation|date=|website=Macfound.org|accessdate=2016-07-02}} In 2007, Kiessling was inducted as a member of the United States National Academy of Sciences{{cite web |title=Laura L. Kiessling |url=http://www.nasonline.org/member-directory/members/3010865.html |website=National Academy of Sciences Member Directory |access-date=16 March 2022}} and in 2017, she received the Tetrahedron Prize for Creativity in Organic Chemistry.{{Cite book|url=https://www.journals.elsevier.com/tetrahedron/awards/tetrahedron-prize-for-creativity-in-organic-chemistry|title=Tetrahedron Prize for Creativity in Organic Chemistry|access-date=2018-07-30}}

Kiessling is a Fellow of the American Association for the Advancement of Sciences{{cite web|url=http://php.aaas.org/about/aaas_fellows/list.php|title=AAAS - The World's Largest General Scientific Society ||website=Php.aaas.org|archiveurl=https://web.archive.org/web/20140115191304/http://php.aaas.org/about/aaas_fellows/list.php|archivedate=2014-01-15|url-status=dead|accessdate=2016-07-02}} and the American Chemical Society,{{cite web|url=http://pubs.acs.org/cen/fellows/|title=2010 ACS Fellows | ACS News | Chemical & Engineering News|date=|website=Pubs.acs.org|accessdate=2016-07-02}} as well as an elected member of the American Academy of Arts and Sciences,{{cite web|url=http://www.amacad.org/members/alphaList.pdf|title=Alphabetical Index of Active Members|website=Amacad.org|accessdate=2016-07-02|archive-url=https://web.archive.org/web/20160527025239/http://www.amacad.org/members/alphaList.pdf|archive-date=2016-05-27|url-status=dead}} American Philosophical Society,{{Cite web|url=http://axial.acs.org/2017/05/09/laura-kiessling-aps/|title=ACS Chemical Biology EIC Laura L. Kiessling Elected to the American Philosophical Society|last=Key|first=Ellie|date=2017-05-09|website=ACS Axial|access-date=2018-07-30}} and American Academy of Microbiology.{{cite web|url=http://academy.asm.org/index.php/fellows/fellows-directory|title=Fellows Directory|archiveurl=https://web.archive.org/web/20110807112021/http://academy.asm.org/index.php/fellows/fellows-directory|archivedate=August 7, 2011|url-status=dead|accessdate=October 8, 2011}} Since 2005, she has served as the founding editor-in-chief of ACS Chemical Biology.{{cite web|url=http://archives.microbeworld.org/scientists/interviews/LauraKiessling.aspx|title=Laura Kiessling|archiveurl=https://web.archive.org/web/20120313235234/http://archives.microbeworld.org/scientists/interviews/LauraKiessling.aspx|archivedate=March 13, 2012|url-status=dead|accessdate=July 18, 2012}}{{cite web|url=http://www.news.wisc.edu/13738|title=Two faculty elected to National Academy of Sciences|last=Sakai|first=Jill|date=2007-05-01|website=News.wisc.edu|accessdate=2016-07-02}}{{cite web|url=http://www.wisconsinacademy.org/node/116|title=Laura Kiessling|date=12 September 2012|website=Wisconsinacademy.org|accessdate=2016-07-02}} Kiessling is also the cofounder of Quintessence Biosciences, a company that is working to translate her technological advances into cures for various diseases.{{cite web|url=http://www.quintbio.com/science.asp|title=Quintessence Biosciences, Inc|archiveurl=https://web.archive.org/web/20121008005050/http://www.quintbio.com/science.asp|archivedate=October 8, 2012|url-status=usurped|accessdate=July 18, 2012}} She has been selected as one of the fifty top research and development "Stars to Watch" by Industry Week.{{cite web|url=http://www.industryweek.com/articles/50_rd_stars_to_watch_519.aspx|title=50 R&D Stars To Watch|author=Vivian Pospisil|date=2004-12-21|website=Industryweek.com|accessdate=2016-07-02}}

• 2022 Elected Member, National Academy of Medicine{{Cite web |last=Doughty |first=Danielle |date=2022-10-17 |title=Laura Kiessling Elected to National Academy of Medicine |url=https://chemistry.mit.edu/chemistry-news/laura-kiessling-elected-to-national-academy-of-medicine/ |access-date=2022-10-17 |website=MIT Department of Chemistry |language=en-US}}
• 2019 Centenary Prize, Royal Society of Chemistry{{Cite web|url=https://chemistry.mit.edu/chemistry-news/kiessling-awarded-2019-centenary-prize/|title=Kiessling Awarded 2019 Centenary Prize – MIT Department of Chemistry|date=13 May 2019 |language=en-US|access-date=2019-05-14}}
• 2017 Tetrahedron Prize for Creativity in Organic Chemistry
• 2017 Elected Member, American Philosophical Society{{Cite web|url=http://axial.acs.org/2017/05/09/laura-kiessling-aps/|title=ACS Chemical Biology EIC Laura L. Kiessling Elected to the American Philosophical Society|last=Key|first=Ellie|date=2017-05-09|website=ACS Axial|access-date=2018-07-30}}
• 2016 Willard Gibbs Award, Chicago Section of the American Chemical Society{{Cite web|url=http://axial.acs.org/2016/03/16/laura-l-kiessling-wins-2016-gibbs-award/|title=ACS Chemical Biology EIC Laura L. Kiessling Wins 2016 Gibbs Award|last=Stanchak|first=Jesse|date=2016-03-16|website=ACS Axial|access-date=2018-07-30}}
• 2014 ACS Alfred Bader Award in Bioinorganic and Bioorganic Chemistry{{Cite web|url=http://cen.acs.org/articles/91/i36/ACS-2014-National-Award-Winners.html?h=1506832942|title=ACS 2014 National Award Winners {{!}} September 9, 2013 Issue - Vol. 91 Issue 36 {{!}} Chemical & Engineering News|website=cen.acs.org|access-date=2016-10-09}}
• 2010 Fellow, American Chemical Society{{cite web|url=http://pubs.acs.org/cen/fellows/|title=2010 ACS Fellows | ACS News | Chemical & Engineering News|date=|website=Pubs.acs.org|accessdate=2016-07-02}}
• 2008 Guggenheim Fellowship{{cite web|url=http://www.gf.org/fellows|title=John Simon Guggenheim Foundation | Fellows|date=2014-06-20|website=Gf.org|accessdate=2016-07-02}}
• 2007 Elected Member, National Academy of Sciences{{cite web|url=http://nas.nasonline.org/site/Dir/960368144?pg=vprof&mbr=1010590&returl=http%3A%2F%2Fnas.nasonline.org%2Fsite%2FDir%2F960368144%3Fpg%3Dsrch%26view%3Dbasic&retmk=search_again_link|title=National Academy of Sciences|date=|website=Nas.nasonline.org|accessdate=2016-07-02}}
• 2007 Elected Member, American Academy of Microbiology{{cite web|url=http://academy.asm.org/index.php/fellows/fellows-directory|title=Fellows Directory|archiveurl=https://web.archive.org/web/20110807112021/http://academy.asm.org/index.php/fellows/fellows-directory|archivedate=August 7, 2011|url-status=dead|accessdate=October 8, 2011}}
• 2007 Garvan–Olin Medal, American Chemical Society{{cite web|url=http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1319&content_id=CTP_004521&use_sec=true&sec_url_var=region1&__uuid=5524d8c0-e7f3-4b1c-a5c3-82822f8da66a|title=American Chemical Society - American Chemical Society|date=|website=Portal.acs.org|accessdate=2016-07-02}}
• 2003 Elected Member, American Academy of Arts & Sciences{{cite web|url=http://www.amacad.org/members/alphaList.pdf|title=Alphabetical Index of Active Members|website=Amacad.org|accessdate=2016-07-02|archive-url=https://web.archive.org/web/20160527025239/http://www.amacad.org/members/alphaList.pdf|archive-date=2016-05-27|url-status=dead}}
• 2003 Fellow, American Association for the Advancement of Science{{cite web|url=http://php.aaas.org/about/aaas_fellows/list.php|title=AAAS - The World's Largest General Scientific Society ||website=Php.aaas.org|archiveurl=https://web.archive.org/web/20140115191304/http://php.aaas.org/about/aaas_fellows/list.php|archivedate=2014-01-15|url-status=dead|accessdate=2016-07-02}}
• 1999–2004 John D. and Catherine T. MacArthur Foundation Fellowship
• 1999 Arthur C. Cope Scholar Award{{cite web|url=https://www.acs.org/content/acs/en/funding-and-awards/awards/national/bytopic/arthur-cope-scholar-award.html|title=Arthur C. Cope Scholar Awards|website=Portal.acs.org|accessdate=2018-07-30}}

{{Reflist|30em}}

• [http://en.scientificcommons.org/laura_l_kiessling "Laura L. Kiessling", Scientific Commons]
• {{usurped|1=[https://web.archive.org/web/20120701115725/http://www.quintbio.com/ Quintessence Biosciences, Inc.]}}
• [https://web.archive.org/web/20160916142145/https://biochem.wisc.edu/labs/kiessling The Kiessling Lab website]
• [https://biochem.wisc.edu/cbit Chemistry-Biology Interface Training Program]
• {{PubMedAuthorSearch|Kiessling|LL}}

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{{DEFAULTSORT:Kiessling, Laura L}}

Category:American women biochemists

Category:Living people

Category:Massachusetts Institute of Technology School of Science alumni

Category:University of Wisconsin–Madison faculty

Category:Yale University alumni

Category:MacArthur Fellows

Category:Members of the United States National Academy of Sciences

Category:21st-century American women scientists

Category:1960 births

Category:Members of the American Philosophical Society

Category:Fellows of the American Academy of Arts and Sciences

Category:Fellows of the American Association for the Advancement of Science

Category:People from Lake Mills, Wisconsin

Category:American academic journal editors

Category:Fellows of the American Academy of Microbiology

Category:American women academics

Category:Members of the National Academy of Medicine