Lelio Orci

{{short description|Italian endocrinologist}}

{{Other people||Lelio Orsi|Orci (surname)}}

Lelio Orci (22 March 1937 – 22 October 2019) {{Cite web|url=https://www.frosinonetoday.it/attualita/san-giovanni-morto-scienziato-lelio-orci.html|title=Morto lo scienziato ciociaro Lelio Orci, famoso per le scoperte sul diabete}} was an Italian scientist in the field of endocrinology and diabetes and emeritus professor in the Department of Morphology at the University of Geneva Medical School.{{Cite web |url=http://www.americanscientist.org/issues/pub/all-cells-lead-to-rome |title=All Cells Lead to Rome » American Scientist |access-date=2016-12-14 |archive-url=https://web.archive.org/web/20161220122705/http://www.americanscientist.org/issues/pub/all-cells-lead-to-rome |archive-date=2016-12-20 |url-status=dead }}

Orci was born in 1937 in San Giovanni Incarico. He received his BA in 1958. He studied medicine at the University of Rome, graduating in 1964.{{cite journal|url=http://joe.endocrinology-journals.org/content/102/1/NP.full.pdf|title=The Dale Medallist 1983|journal=Journal of Endocrinology|date=July 1984|volume=102|issue=1|pages=NP–1|doi=10.1677/joe.0.10200NP}} In 1966, he moved to the University of Geneva where he worked ever since. He was chair of the Department of Morphology from 1976 until his retirement in 2000, transitioning to professor emeritus.

Orci is known for his work on cell and tissue biology using electron microscopy. In the first part of his research career, Orci's laboratory largely studied the organization of the pancreatic islet of Langerhans, as well as the secretion pathway of insulin from the beta cell.{{cite journal|title=In Memoriam: Lelio Orci, 1937-2019 |vauthors=Montesano R, Schekman R, Rothman J, Perrelet A |doi=10.1073/pnas.1920094117 |journal=Proc Natl Acad Sci U S A |date=January 2020 |volume=117 |issue=1 |pages=15-17|pmc=6955317 }} His group was the first to utilize immunogold labelling to localize intracellular proteins (published in 1980),{{cite web|archiveurl=https://web.archive.org/web/20140206200906/http://www.ebsciences.com/papers/immusem.htm |url=http://www.ebsciences.com/papers/immusem.htm |url-status=dead |title=Immunogold Labelling in Scanning Electron Microscopy |archivedate=6 February 2014 |publisher=Energy Beam Sciences}} and among the first to use freeze-fracture with electron microscopy to study a cell's internal organization. In 1984, he began collaborating with James Rothman on the work in vesicle trafficking that eventually earned Rothman, Randy Schekman, and Thomas C. Südhof the Nobel Prize.{{Cite web |url=https://www.nobelprize.org/nobel_prizes/medicine/laureates/2013/rothman-lecture.pdf |title=Archived copy |access-date=2016-12-14 |archive-url=https://web.archive.org/web/20170315031341/http://www.nobelprize.org/nobel_prizes/medicine/laureates/2013/rothman-lecture.pdf |archive-date=2017-03-15 |url-status=dead }}