Lentinan

Lentinan is a β-1,3 beta-glucan with β-1,6 branching. It has a molecular weight of 500,000 Da and specific rotation of +14-22° (NaOH).

An in vitro experiment showed lentinan stimulated production of white blood cells in the human cell line U937.{{cite journal | vauthors = Sia GM, Candlish JK | title = Effects of shiitake (Lentinus edodes) extract on human neutrophils and the U937 monocytic cell line | journal = Phytotherapy Research | volume = 13 | issue = 2 | pages = 133–137 | date = March 1999 | pmid = 10190187 | doi = 10.1002/(SICI)1099-1573(199903)13:2<133::AID-PTR398>3.0.CO;2-O | doi-access = free }} Lentinan is thought to be inactive in humans when given orally and is therefore administered intravenously. The authors of an in vivo study of lentinan suggested that the compound may be active when administered orally in mice.{{cite journal | vauthors = Ng ML, Yap AT | title = Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes) | journal = Journal of Alternative and Complementary Medicine | volume = 8 | issue = 5 | pages = 581–589 | date = October 2002 | pmid = 12470439 | doi = 10.1089/107555302320825093 }}

Lentinan has been the subject of a limited number of clinical studies in cancer patients in Japan;{{cite journal | vauthors = Yang P, Liang M, Zhang Y, Shen B | title = Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC | journal = Advances in Therapy | volume = 25 | issue = 8 | pages = 787–794 | date = August 2008 | pmid = 18670743 | doi = 10.1007/s12325-008-0079-x | s2cid = 33140754 | doi-access = free }}{{cite journal | vauthors = Nimura H, Mitsumori N, Takahashi N, Kashimura H, Takayama S, Kashiwagi H, Yanaga K | title = [S-1 combined with lentinan in patients with unresectable or recurrent gastric cancer] | language = ja | journal = Gan to Kagaku Ryoho. Cancer & Chemotherapy | volume = 33 Suppl 1 | issue = 1 | pages = 106–109 | date = June 2006 | pmid = 16897983 }}{{cite journal | vauthors = Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K | title = A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group | journal = Hepato-Gastroenterology | volume = 46 | issue = 28 | pages = 2662–2668 | year = 1999 | pmid = 10522061 }}{{cite journal | vauthors = Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J | title = Individual patient based meta-analysis of lentinan for unresectable/recurrent gastric cancer | journal = Anticancer Research | volume = 29 | issue = 7 | pages = 2739–2745 | date = July 2009 | pmid = 19596954 }}{{cite journal | vauthors = Hazama S, Watanabe S, Ohashi M, Yagi M, Suzuki M, Matsuda K, Yamamoto T, Suga Y, Suga T, Nakazawa S, Oka M | display-authors = 6 | title = Efficacy of orally administered superfine dispersed lentinan (beta-1,3-glucan) for the treatment of advanced colorectal cancer | journal = Anticancer Research | volume = 29 | issue = 7 | pages = 2611–2617 | date = July 2009 | pmid = 19596936 | url = http://ar.iiarjournals.org/content/29/7/2611.full }}{{cite journal | vauthors = Kataoka H, Shimura T, Mizoshita T, Kubota E, Mori Y, Mizushima T, Wada T, Ogasawara N, Tanida S, Sasaki M, Togawa S, Sano H, Hirata Y, Ikai M, Mochizuki H, Seno K, Itoh S, Kawai T, Joh T | display-authors = 6 | title = Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life | journal = Hepato-Gastroenterology | volume = 56 | issue = 90 | pages = 547–550 | year = 2009 | pmid = 19579640 }}{{cite journal | vauthors = Isoda N, Eguchi Y, Nukaya H, Hosho K, Suga Y, Suga T, Nakazawa S, Sugano K | display-authors = 6 | title = Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma | journal = Hepato-Gastroenterology | volume = 56 | issue = 90 | pages = 437–441 | year = 2009 | pmid = 19579616 }}{{cite journal | vauthors = Shimizu K, Watanabe S, Watanabe S, Matsuda K, Suga T, Nakazawa S, Shiratori K | title = Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer | journal = Hepato-Gastroenterology | volume = 56 | issue = 89 | pages = 240–244 | year = 2009 | pmid = 19453066 }} however, evidence of efficacy is lacking.{{cite web|title=Lentinan|url=http://www.webmd.com/vitamins-supplements/ingredientmono-763-lentinan.aspx?activeingredientid=763&activeingredientname=lentinan|publisher=WebMD|access-date=June 10, 2017}}{{cite web|title=Lentinan|url=https://www.mskcc.org/cancer-care/integrative-medicine/herbs/lentinan|publisher=Memorial Sloan Kettering Cancer Center|access-date=June 10, 2017}}

Lentinan has been reported to cause shiitake mushroom dermatitis.{{cite journal | vauthors = Nakamura T | title = Shiitake (Lentinus edodes) dermatitis | journal = Contact Dermatitis | volume = 27 | issue = 2 | pages = 65–70 | date = August 1992 | pmid = 1395630 | doi = 10.1111/j.1600-0536.1992.tb05211.x | s2cid = 7320474 | doi-access = }}

• Medicinal mushrooms

{{Reflist|30em}}

• [https://www.drugs.com/npp/lentinan.html Lentinan] effects (antitumor and others)
• Memorial Sloan-Kettering Cancer Center's page for [http://www.mskcc.org/mskcc/html/69279.cfm Lentinan].

{{Immunostimulants}}

{{Carbohydrates}}

Category:Immunostimulants

Category:Polysaccharides