Leukotriene-C4 synthase
{{infobox enzyme
| Name = leukotriene-C4 synthase
| EC_number = 4.4.1.20
| CAS_number = 90698-32-1
| GO_code = 0004464
| image = 3leo.jpg
| width = 270
| caption = Leukotriene C4 synthase dodecamer, Human
}}
The enzyme leukotriene-C4 synthase (EC 4.4.1.20) catalyzes the reaction
:leukotriene C4 leukotriene A4 + glutathione
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is leukotriene-C4 glutathione-lyase (leukotriene-A4-forming). Other names in common use include leukotriene C4 synthetase, LTC4 synthase, LTC4 synthetase, leukotriene A4:glutathione S-leukotrienyltransferase, (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase, (epoxide-ring-opening), (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming). This enzyme participates in arachidonic acid metabolism.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|2PNO}}, {{PDB link|2UUH}}, and {{PDB link|2UUI}}.
References
{{reflist|1}}
- {{cite journal | vauthors = Bach MK, Brashler JR, ((Morton DR Jr)) | date = 1984 | title = Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase | journal = Arch. Biochem. Biophys. | volume = 230 | pages = 455–65 | pmid = 6324687 | doi = 10.1016/0003-9861(84)90426-0 | issue = 2 }}
- {{cite journal | author = Shimizu T | date = 1988 | title = Enzymes functional in the syntheses of leukotrienes and related compounds | journal = Int. J. Biochem. | volume = 20 | pages = 661–6 | pmid = 2846379 | doi = 10.1016/0020-711X(88)90160-7 | issue = 7 }}
- {{cite journal | vauthors = Lam BK, Austen KF | date = 2002 | title = Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes | journal = Prostaglandins. Other. Lipid. Mediat. | volume = 68-69 | pages = 511–20 | pmid = 12432940 | doi = 10.1016/S0090-6980(02)00052-7 }}
- {{cite journal | vauthors = Christmas P, Weber BM, McKee M, Brown D, Soberman RJ | date = 2002 | title = Membrane localization and topology of leukotriene C4 synthase | journal = J. Biol. Chem. | volume = 277 | pages = 28902–8 | pmid = 12023288 | doi = 10.1074/jbc.M203074200 | issue = 32 | doi-access = free}}
{{Carbon-sulfur lyases}}
{{Enzymes}}
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Category:Enzymes of known structure
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