Leukotriene receptor

{{Short description|Protein family}}

The leukotriene (LT) receptors are G protein-coupled receptors that bind and are activated by the leukotrienes. They include the following proteins:

• Leukotriene B4 receptors (BLTRs) – bind to and are activated by LTB4:
• BLT₁ (Leukotriene B₄ receptor 1) – {{Gene|LTB4R}}
• BLT₂ (Leukotriene B₄ receptor 2) – {{Gene|LTB4R2}}
• Cysteinyl leukotriene receptors (CysLTRs) – bind to and are activated by LTC4, LTD4, and LTE4:
• CysLT₁ (Cysteinyl leukotriene receptor 1) – {{Gene|CYSLTR1}}
• CysLT₂ (Cysteinyl leukotriene receptor 2) – {{Gene|CYSLTR2}}

The recently elucidated CysLT_E, represented by GPR99/OXGR1, may constitute a third CysLTR.{{cite journal | vauthors = Kanaoka Y, Maekawa A, Austen KF | title = Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand | journal = J. Biol. Chem. | volume = 288 | issue = 16 | pages = 10967–72 | year = 2013 | pmid = 23504326 | pmc = 3630866 | doi = 10.1074/jbc.C113.453704 | doi-access = free }}