Leukotriene receptor
{{Short description|Protein family}}
The leukotriene (LT) receptors are G protein-coupled receptors that bind and are activated by the leukotrienes. They include the following proteins:
- Leukotriene B4 receptors (BLTRs) – bind to and are activated by LTB4:
- BLT1 (Leukotriene B4 receptor 1) – {{Gene|LTB4R}}
- BLT2 (Leukotriene B4 receptor 2) – {{Gene|LTB4R2}}
- Cysteinyl leukotriene receptors (CysLTRs) – bind to and are activated by LTC4, LTD4, and LTE4:
- CysLT1 (Cysteinyl leukotriene receptor 1) – {{Gene|CYSLTR1}}
- CysLT2 (Cysteinyl leukotriene receptor 2) – {{Gene|CYSLTR2}}
The recently elucidated CysLTE, represented by GPR99/OXGR1, may constitute a third CysLTR.{{cite journal | vauthors = Kanaoka Y, Maekawa A, Austen KF | title = Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand | journal = J. Biol. Chem. | volume = 288 | issue = 16 | pages = 10967–72 | year = 2013 | pmid = 23504326 | pmc = 3630866 | doi = 10.1074/jbc.C113.453704 | doi-access = free }}
See also
References
{{Reflist|2}}
External links
- [http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=35 IUPHAR GPCR Database – Leukotriene receptors]
- {{MeshName|Leukotriene+Receptors}}
{{Transmembrane receptors}}
{{G protein-coupled receptors}}
{{Leukotrienergics}}
Category:G protein-coupled receptors
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