Ligneous conjunctivitis
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| name = Ligneous conjunctivitis
| synonyms = Conjunctivitis lignosa{{cite web |last1=RESERVED |first1=INSERM US14-- ALL RIGHTS |title=Orphanet: Ligneous conjunctivitis |url=https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=97231 |website=www.orpha.net |access-date=26 June 2019 |language=en}}
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| field = ophthalmology
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Ligneous conjunctivitis is a rare form of chronic conjunctivitis characterized by recurrent, fibrin-rich pseudomembranous lesions of wood-like consistency that develop mainly on the underside of the eyelid (tarsal conjunctiva).{{Cite journal | last1 = Schuster | first1 = V. | last2 = Seregard | first2 = S. | title = Ligneous conjunctivitis | journal = Survey of Ophthalmology | volume = 48 | issue = 4 | pages = 369–388 | year = 2003 | pmid = 12850227 | doi=10.1016/s0039-6257(03)00056-0| s2cid = 13501130 }} It is generally a systemic disease which may involve the periodontal tissue, the upper and lower respiratory tract, kidneys, middle ear, and female genitalia.{{cite web|title=Ligneous conjunctivitis|url=http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=97231|publisher=Orphanet|access-date=July 21, 2012}} It can be sight-threatening, and death can occasionally occur from pulmonary involvement.{{citation needed|date=July 2012}}
It has been speculated hola ligneous conjunctivitis may be a manifestation of IgG4-related disease (IgG4-RD) involving the conjunctiva.{{cite journal |author1=Chiang Wei-Yu |author2=iu Ting-Ting |author3=Huang Wan-Ting |author4=Kuo Ming-Tse |date=9 September 2016 |title=Co-existing ligneous conjunctivitis and IgG4-related disease |url=http://www.ijo.in/article.asp?issn=0301-4738;year=2016;volume=64;issue=7;spage=532;epage=534;aulast=Chiang |journal=Indian Journal of Ophthalmology |volume=64 |issue=7 |pages=532–534 |doi=10.4103/0301-4738.190154 |pmid= 27609168 |pmc=5026081 |doi-access=free }}
Pathogenesis
Histopathological findings from affected humans indicate that wound healing is impaired due to a deficiency in plasmin-mediated extracellular fibrinolysis. Episodes may be triggered by minor trauma, eye surgery, or by systemic events such as infections or antifibrinolytic therapy. Histology shows amorphous subepithelial deposits of eosinophilic material consisting predominantly of fibrin.{{clarify|date=July 2012}}
Diagnosis
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Treatment
Ligneous conjunctivitis may be managed by topical treatments of plasminogen, topical and subconjunctival fresh frozen plasma, and fibrinolytic therapy.{{cite web|title=Ligneous Conjunctivitis|url=http://www.images.missionforvisionusa.org/anatomy/2006/03/what-is-ligneous-conjunctivitis.html|publisher=Ocular Pathology|access-date=July 21, 2012}}
References
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External links
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| ICD10 = H10.4
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| OMIM = 217090
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