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Lipid-phosphate phosphatase

{{enzyme

| Name = Lipid-phosphate phosphatase

| EC_number = 3.1.3.76

| CAS_number =

| GO_code =

| image =

| width =

| caption =

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The enzyme lipid-phosphate phosphatase* {{cite journal |vauthors=Newman JW, Morisseau C, Harris TR, Hammock BD | date = 2003 | title = The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | pages = 1558–63 | pmid = 12574510 | doi = 10.1073/pnas.0437724100 | issue = 4 | pmc = 149871 | bibcode = 2003PNAS..100.1558N | doi-access = free }}{{cite journal |vauthors=Oesch F, Arand M | date = 2003 | title = The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | pages = 1552–7 | pmid = 12574508 | doi = 10.1073/pnas.0437829100 | issue = 4 | pmc = 149870 | bibcode = 2003PNAS..100.1552C | doi-access = free }}{{cite journal |vauthors=Newman JW, Morisseau C, Harris TR, Hammock BD | date = 2003 | title = The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | pages = 1558–63 | pmid = 12574510 | doi = 10.1073/pnas.0437724100 | issue = 4 | pmc = 149871 | bibcode = 2003PNAS..100.1558N | doi-access = free }}{{cite journal |vauthors=Oesch F, Arand M | date = 2003 | title = The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | pages = 1552–7 | pmid = 12574508 | doi = 10.1073/pnas.0437829100 | issue = 4 | pmc = 149870 | bibcode = 2003PNAS..100.1552C | doi-access = free }} (EC 3.1.3.76) catalyzes the reaction

:(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O \rightleftharpoons (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase. Other names in common use include hydroxy fatty acid phosphatase, dihydroxy fatty acid phosphatase, hydroxy lipid phosphatase, sEH (ambiguous), and soluble epoxide hydrolase (ambiguous).

See also

References

{{reflist|1}}

  • {{cite journal |vauthors=Morisseau C, Hammock BD | date = 2005 | title = Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles | journal = Annu. Rev. Pharmacol. Toxicol. | volume = 45 | pages = 311–33 | pmid = 15822179 | doi = 10.1146/annurev.pharmtox.45.120403.095920 }}
  • {{cite journal |vauthors=Tran KL, Aronov PA, Tanaka H, Newman JW, Hammock BD, Morisseau C | date = 2005 | title = Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase | journal = Biochemistry | volume = 44 | pages = 12179–87 | pmid = 16142916 | doi = 10.1021/bi050842g | issue = 36 | pmc = 1473036 }}
  • {{cite journal |vauthors=Newman JW, Morisseau C, Hammock BD | date = 2005 | title = Epoxide hydrolases: their roles and interactions with lipid metabolism | journal = Prog. Lipid Res. | volume = 44 | pages = 1–51 | pmid = 15748653 | doi = 10.1016/j.plipres.2004.10.001 | issue = 1 }}
  • {{cite journal |vauthors=Srivastava PK, Sharma VK, Kalonia DS, Grant DF | date = 2004 | title = Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure | journal = Arch. Biochem. Biophys. | volume = 427 | pages = 164–9 | pmid = 15196990 | doi = 10.1016/j.abb.2004.05.003 | issue = 2 }}
  • {{cite journal|author4-link=David W. Christianson|vauthors=Gomez GA, Morisseau C, Hammock BD, Christianson DW | date = 2004 | title = Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis | journal = Biochemistry | volume = 43 | pages = 4716–23 | pmid = 15096040 | doi = 10.1021/bi036189j | issue = 16 }}

{{Esterases}}

{{Enzymes}}

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Category:EC 3.1.3

Category:Enzymes of unknown structure

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