List of Doctors characters introduced in 2021#Billy Parker

! scope="col" | Episode date(s)

! scope="col" | Actor

! scope="col" | Circumstances

| rowspan="3" | 8 February

| Nina De Cosimo{{Cite news|url=https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-big-lie/|title=Doctors spoilers: Will Al Haskey continue with his BIG lie?|work=What's on TV|publisher=Future plc|access-date=8 February 2021|last=Timblick|first=Simon|archive-date=11 February 2021|archive-url=https://web.archive.org/web/20210211092027/https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-big-lie/|url-status=live}}

| A dancer who believes she has a stomach ache. After seeing Ruhma Carter (Bharti Patel), who informs her that she is in labour, she gives birth.

| Emily De Cosimo

| The sister of Mariah (Nina De Cosimo).

| Maggie Daniels

| The mother of Mariah (De Cosimo) who informs her children that when she gave birth, she had post-natal depression.

| rowspan="3" | 9 February

| Richard Hope{{Cite news|url=https://www.whatsontv.co.uk/events/doctors-spoilers-big-trouble-karen-hollins/|title=Doctors spoilers: There's BIG trouble for Karen Hollins...|work=What's on TV|publisher=Future plc|access-date=9 February 2021|last=Timblick|first=Simon|archive-date=10 February 2021|archive-url=https://web.archive.org/web/20210210205701/https://www.whatsontv.co.uk/events/doctors-spoilers-big-trouble-karen-hollins/|url-status=live}}

| A resident of a care home. He believes that Martin Blake (Lindon Alexander) is a Russian spy and runs away to get proof of his beliefs. Alongside Rob Hollins (Chris Walker), he later discovers that care home manager Nancy Davies (Suzann McLean) is the brother of Martin and that they are working together to steal money from the residents.

| Suzann McLean

| The manager of a care home in Letherbridge who has been working with her brother Martin (Lindon Alexander) to steal money from residents.

| Lindon Alexander

| The brother of Nancy (Suzann McLean) who he works with to steal money from residents of a care home.

| rowspan="4" | 10 February

| Jonathan Jaynes{{Cite news|url=https://www.whatsontv.co.uk/events/doctors-spoilers-emma-reid-terrible-truth/|title=Doctors spoilers: Will Emma Reid discover the terrible truth?|work=What's on TV|publisher=Future plc|access-date=10 February 2021|last=Timblick|first=Simon|archive-date=28 April 2021|archive-url=https://web.archive.org/web/20210428175904/https://www.whatsontv.co.uk/events/doctors-spoilers-emma-reid-terrible-truth/|url-status=live}}

| The father of Lily Walker (Verity Rushworth). Al Haskey (Ian Midlane), Lily's fiancé, berates him for being a flat earther.

| Sherry Baines

| The mother of Lily Walker (Rushworth) who is unhappy with her marriage to husband Terry (Jonathan Jaynes).

| James Flynn

| An NHS fraud prevention officer who investigates how many ghost patients are on the Mill's patient list.

| Maria Forrester

| A patient of the Mill who has fraudulently received over £400,000 worth of treatment from the NHS.

| rowspan="2" | 15 February

| Katharine Bennett-Fox{{Cite news|url=https://www.whatsontv.co.uk/events/doctors-spoilers-karen-hollins-shock-theory-tom-robson/|title=Doctors spoilers: Karen Hollins has a SHOCK theory about Tom Robson...|work=What's on TV|publisher=Future plc|access-date=15 February 2021|last=Timblick|first=Simon|archive-date=12 February 2021|archive-url=https://web.archive.org/web/20210212075020/https://www.whatsontv.co.uk/events/doctors-spoilers-karen-hollins-shock-theory-tom-robson/|url-status=live}}

| An employee at a leisure centre that feels mistreated by her new boss, Kelvin Fleck (Edward Kelly). After encouragement from Zara Carmichael (Elisabeth Dermot Walsh), she quits to pursue a career as a personal trainer.

| Edward Kelly

| A man who becomes the boss of his uncle's leisure centre and inflicts a variety of changes into the workplace.

| rowspan="3" | 16 February

| Robin Bowerman{{Cite news|url=https://www.whatsontv.co.uk/events/doctors-spoilers-lily-walker-stalking-al-haskey/|title=Doctors spoilers: Is Lily Walker STALKING Al Haskey?|work=What's on TV|publisher=Future plc|access-date=16 February 2021|last=Timblick|first=Simon|archive-date=28 April 2021|archive-url=https://web.archive.org/web/20210428175929/https://www.whatsontv.co.uk/events/doctors-spoilers-lily-walker-stalking-al-haskey/|url-status=live}}

| A man who learns from Sid Vere (Ashley Rice) that his wife Alice's (Susan Penhaligon) cancer treatment will not go ahead, since she is too weak for invasive treatment.

| Susan Penhaligon

| A woman suffering from dementia, Parkinson's and cancer.

| Polly Maberly

| The daughter of Alice (Penhaligon).

| rowspan="3" | 17 February

| Melissa Parker{{Cite news|url=https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-spooked-lily-walker/|title=Doctors spoilers: Al Haskey is SPOOKED by Lily Walker's behaviour|last=Timblick|first=Simon|access-date=17 February 2021|publisher=Future plc|archive-date=14 February 2021|archive-url=https://web.archive.org/web/20210214125219/https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-spooked-lily-walker/|url-status=live}}

| A medical student who funds her research into degenerative diseases by performing life-threatening facial trials on people.

| Charlotte Weston

| A client of Regan Law's (Melissa Parker).

| Kay Purcell

| A client of Regan Law's (Parker) who visits Emma Reid (Dido Miles). She has an allergic reaction to Regan's treatment and is taken to A&E.

| rowspan="2" | 18 February

| Marc Pickering{{Cite news|url=https://www.whatsontv.co.uk/events/doctors-spoilers-who-does-bear-sylvester-save/|title=Doctors spoilers: WHO does Bear Sylvester try to save?|work=What's on TV|publisher=Future plc|last=Timblick|first=Simon|access-date=18 February 2021|archive-date=18 February 2021|archive-url=https://web.archive.org/web/20210218061948/https://www.whatsontv.co.uk/events/doctors-spoilers-who-does-bear-sylvester-save/|url-status=live}}

| A patient seeing Al Haskey (Ian Midlane). After he opens up to Al about his failing relationship with Katrina Anderson (Jessica Murrain), Dixie gets on the roof of the Mill to get Katrina's attention.

| Jessica Murrain

| A maintenance worker at the Mill. Her boyfriend, Dixie Calthorpe (Marc Pickering), gets on the roof at the Mill to get her attention after she expresses plans to move abroad.

| rowspan="4" | 22 February

| Liam Tamne{{Cite news|url=https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-confronts-lily-walker/|title=Doctors spoilers: Al Haskey confronts ex-fiancee Lily Walker|work=What's on TV|publisher=Future plc|last=Timblick|first=Simon|access-date=22 February 2021|archive-date=19 February 2021|archive-url=https://web.archive.org/web/20210219062250/https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-confronts-lily-walker/|url-status=live}}

| A detective sergeant who investigates the death of Kelly, a drug dealer.

| Gabriel Scott

| A student support officer at Letherbridge University.

| Jaz Hutchins

| A university student who attempts to aid DS Suresh Nupur (Liam Tamne) in his investigations.

| Felix Forde

| A university student who accidentally pushed drug dealer Kelly down a flight of stairs.

| 24 February–26 May

| Tommy Sim'aan{{Cite episode|title=Trouble|url=https://www.bbc.co.uk/programmes/m000sm7v|series=Doctors|series-link=Doctors (2000 TV series)|credits=Writer: Peter Eryl Lloyd; Director: Merlyn Rice; Producer: Caroline Slater|network=BBC|station=BBC One|air-date=24 February 2021|access-date=16 February 2021|archive-date=25 May 2021|archive-url=https://web.archive.org/web/20210525091257/https://www.bbc.co.uk/programmes/m000sm7v|url-status=live}}

| The brother of Billy (Daniel Cornish). He threatens Luca McIntyre (Ross McLaren) since he blames him for Billy's death.

| rowspan="6" | {{nowrap|24 February}}

| Alun Raglan

| The former boss of Luca McIntyre (McLaren). Luca quits working for him after Noah calls him a homophobic slur.

| Melanie Kilburn

| A patient of Luca McIntyre (McLaren).

| Daniel Cornish

| The boyfriend of Luca McIntyre (McLaren) who dies in a car accident.

| Bharti Patel

| A colleague Luca McIntyre's (McLaren).

| Matthew Chambers

| A consultant for medication at Noah Levi's (Alun Raglan) surgery.

| Sarah Moyle

| A friend of Luca McIntyre's (McLaren).

| rowspan="3" | 25 February

| Paul McQuaid{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: More murder SHOCKS for Karen and Rob Hollins! |url=https://www.whatsontv.co.uk/events/doctors-spoilers-murder-shocks-karen-rob-hollins/ |access-date=25 February 2021 |work=What's on TV |publisher=Future plc |archive-date=28 April 2021 |archive-url=https://web.archive.org/web/20210428175927/https://www.whatsontv.co.uk/events/doctors-spoilers-murder-shocks-karen-rob-hollins/ |url-status=live }}

| A porter at St. Phils hospital who is expecting a baby with Jane Goodwin (Kate Somerton). Jane later informs him that she has miscarried the baby and when he is only concerned about trying for another baby, she ends their relationship.

| Kate Somerton

| A patient of Ruhma Carter's (Bharti Patel) who miscarries her baby.

| {{nowrap|Anjela Lauren Smith}}

| A social worker who informs Karen Hollins (Jan Pearson) that she cannot continue caring for Tom Robson (Max True) due to his violence.

| rowspan="2" | 1–23 March

| Silvia Presente{{Cite news|url=https://www.whatsontv.co.uk/events/doctors-spoilers-luca-mcintyre/|title=Doctors spoilers: Luca Mcintyre clashes with the surgery staff!|work=What's on TV|publisher=Future plc|access-date=1 March 2021|last=Timblick|first=Simon|archive-date=28 April 2021|archive-url=https://web.archive.org/web/20210428175904/https://www.whatsontv.co.uk/events/doctors-spoilers-luca-mcintyre/|url-status=live}}

| rowspan="2" | A pair of environmental activists at Letherbridge University. Due to disagreeing with the university going into partnership with a company called Secuto, they glue their hands to a classroom door. Daniel Granger (Matthew Chambers) is called out to dissolve the glue. They explain that Secuto use fossil fuels such as oil, which has a negative impact on the environment. Daniel advises them to protest in a different way, and the pair decide to do a hunger strike. Daniel informs them that they will die if they continue the strike. Maisie and Anita confront pro-vice-chancellor Matthew Portman (Jason Thorp), who tells them that the strike will not impact the partnership deal. Anita's classmate Eddie Bryant (Edward Nkom) disagrees with their protest, and after the pair argue, Anita collapses and is taken into hospital. She reveals that she has Chron's disease, which leads to her quitting the hunger strike due to her health. Maisie continues the strike for another week, but due to feeling weak, she reluctantly quits.

| {{nowrap|Hannah Khalique-Brown}}

| 1 March

| {{nowrap|Anna Martine-Freeman}}

| A con artist who tries to scam Valerie Pitman (Sarah Moyle) out of £850 by claiming to be a hand model agent.

| rowspan="3" | 2 March

| Rupert Holliday-Evans{{Cite news|url=https://www.whatsontv.co.uk/events/doctors-spoilers-what-on-earth-valerie-pitman/|title=Doctors spoilers: What on earth is Valerie Pitman doing?!|work=What's on TV|access-date=2 March 2021|last=Timblick|first=Simon|publisher=Future plc|archive-date=26 February 2021|archive-url=https://web.archive.org/web/20210226171555/https://www.whatsontv.co.uk/events/doctors-spoilers-what-on-earth-valerie-pitman/|url-status=live}}

| A man with a tumour in his frontal lobe, making him believe in alien activity.

| Luke Lowry

| The son of Bob (Rupert Holliday-Evans).

| Tom Aldwinckle

| The site manager of a team building resort that the colleagues of the Mill visit.

| rowspan="3" | 3 March

| Toyin Omari-Kinch{{Cite news|url=https://www.whatsontv.co.uk/events/doctors-spoilers-surgery-nurse-luca-mcintyre-homeless/|title=Doctors spoilers: Surgery nurse Luca Mcintyre is still homeless|work=What's on TV|access-date=3 March 2021|last=Timblick|first=Simon|publisher=Future plc|archive-date=3 March 2021|archive-url=https://web.archive.org/web/20210303073918/https://www.whatsontv.co.uk/events/doctors-spoilers-surgery-nurse-luca-mcintyre-homeless/|url-status=live}}

| An ex-prisoner who attends counselling sessions with Jimmi Clay (Adrian Lewis Morgan).

| Dominique Jackson

| The girlfriend of Jason Kendrick (Toyin Omari-Kinch) who struggles to process that he is an ex-prisoner due to having been in an abusive relationship prior to meeting him.

| Jimmy Fairhurst

| A colleague of Jason Kendrick (Omari-Kinch).

| rowspan="4" | 4 March

| Lesley Molony{{Cite episode|title=Sweet Child o' Mine|url=https://www.bbc.co.uk/programmes/m000stzy|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|air-date=4 March 2021|access-date=4 March 2021|archive-date=2 June 2021|archive-url=https://web.archive.org/web/20210602152149/https://www.bbc.co.uk/programmes/m000stzy|url-status=live}}

| The mother of Charley (Grace Molony), who is dying from leukaemia. She finds her estranged daughter Maya Clough (Matilda Tucker) in the hope that she can donate a stem cell.

| Grace Molony

| A woman dying from leukaemia. She meets her estranged sister Maya Clough (Tucker) when her mother hopes that Maya can donate a stem cell to her.

| Matilda Tucker

| The pregnant estranged sister of Charley Webb (Molony).

| Letitia Hector

| A woman that has a friends with benefits relationship with Bear Sylvester (Dex Lee), until Sid Vere's (Ashley Rice) kind nature shows her that she wants more from a partner.

| rowspan="2" | 8 March

| Blue Merrick{{Cite episode|title=Cold Reading|url=https://www.bbc.co.uk/programmes/m000t1c1|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|air-date=8 March 2021|access-date=8 March 2021|archive-date=28 April 2021|archive-url=https://web.archive.org/web/20210428175931/https://www.bbc.co.uk/programmes/m000t1c1|url-status=live}}

| A friend of Zara Carmichael's (Walsh) who visits a psychic Grace Perlman (Ellie Darvill), to cope with the death of her son.

| Ellie Darvill

| A psychic who Zara Carmichael (Walsh) exposes for taking advantage of grieving people.

| 9–23 March

| Jason Thorp{{Cite episode|title=Midwife Crisis|url=https://www.bbc.co.uk/programmes/m000t1dh|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|air-date=9 March 2021|access-date=9 March 2021|archive-date=28 April 2021|archive-url=https://web.archive.org/web/20210428175934/https://www.bbc.co.uk/programmes/m000t1dh|url-status=live}}

| The pro-vice-chancellor of Letherbridge University. He meets with Daniel Granger (Matthew Chambers) to discuss the hunger strike led by students Anita Chandola (Hannah Khalique-Brown) and Maisie Wilson (Silvia Presente), as he wants them to stop the strike for financial reasons. After facing pressure from the students and Daniel threatening to pull surgery services from the university, he begins attending counselling sessions with Jimmi Clay (Adrian Lewis Morgan).

| rowspan="3" | 9 March

| John Askew

| A man who aspires to be a midwife. He helps to deliver his child with wife Poppy (Elizabeth Twells).

| Elizabeth Twells

| A woman who gives birth to her child with husband Max (John Askew).

| William Ilkley

| The father of Max (Askew).

| rowspan="4" | 10 March

| Emma Manton{{Cite episode|title=Imposter|url=https://www.bbc.co.uk/programmes/m000t270|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|air-date=10 March 2021|access-date=10 March 2021|archive-date=11 March 2021|archive-url=https://web.archive.org/web/20210311011158/https://www.bbc.co.uk/programmes/m000t270|url-status=live}}

| A woman with schizophrenia who becomes convinced that her daughter Rosie (Naomi Morris) was swapped at birth.

| Edward Nkom

| A classmate of Anita Chandola's (Khalique-Brown) who disagrees with her protest against Secuto.

| Naomi Morris

| The daughter of Debbie (Emma Manton), who is unaware of her mother's mental illness.

| Cally Lawrence

| The mother of Debbie (Manton) who reveals to Rosie (Morris) that Debbie has schizophrenia.

| 11–16 March

| {{nowrap|Buckso Dhillon-Woolley{{Cite episode|title=Sugar Sugar|url=https://www.bbc.co.uk/programmes/m000t2cp|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|air-date=11 March 2021|access-date=11 March 2021|archive-date=12 March 2021|archive-url=https://web.archive.org/web/20210312014713/https://www.bbc.co.uk/programmes/m000t2cp|url-status=live}}}}

| The mother of Anita (Khalique-Brown). When Anita collapses from a hunger strike, Serena blames her friend, Maisie Wilson (Presente).

| rowspan="3" | 11 March

| David Schaal

| The sugar daddy of Chloe Jardine (Rebecca Finch), who tells her that he has developed romantic feelings for her.

| Rebecca Finch

| The sugar baby of Colin Turner (David Schaal).

| Matt Barkley

| The boyfriend of Chloe Jardine (Finch).

| rowspan="3" | 15 March

| Ilan Galkoff{{Cite episode|title=Sammy|url=https://www.bbc.co.uk/programmes/m000t94v|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|air-date=15 March 2021|access-date=15 March 2021|archive-date=15 March 2021|archive-url=https://web.archive.org/web/20210315150756/https://www.bbc.co.uk/programmes/m000t94v|url-status=live}}

| A 14-year-old who vandalises Bear Sylvester's (Lee) car. Bear later discovers that Sharon Coombs (Gemma Layton) has groomed him into selling drugs.

| Calum Hayes

| The disabled brother of Sammy (Ilan Galkoff). He takes Sammy's LSD and jumps out of a window.

| Gemma Layton

| A drug dealer who grooms Sammy Russell (Galkoff) into selling drugs by posing as a carer.

| rowspan="3" | 16 March

| Trevor Laird{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Can Daniel Granger end the hunger strike? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-daniel-granger-hunger-strike/ |access-date=16 March 2021 |work=What's on TV |publisher=Future plc |archive-date=15 March 2021 |archive-url=https://web.archive.org/web/20210315212412/https://www.whatsontv.co.uk/events/doctors-spoilers-daniel-granger-hunger-strike/ |url-status=live }}

| The overbearing father of Akua (Yasmin Mwanza).

| Yasmin Mwanza

| A woman who struggles when going into labour.

| Tej Obano

| The partner of Akua Asante (Mwanza).

| rowspan="2" | 17 March

| Eoin Geoghegan{{Cite episode|title=Daddy's Girl|url=https://www.bbc.co.uk/programmes/m000t96t|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|air-date=17 March 2021|access-date=17 March 2021|archive-date=2 June 2021|archive-url=https://web.archive.org/web/20210602152223/https://www.bbc.co.uk/programmes/m000t96t|url-status=live}}

| The father of sixth form medical student Teresa (Alexandra O'Neill). He injures his wrist, but is agitated about registering at the Mill as he cannot read.

| Alexandra O'Neill

| A sixth form medical student who shadows Sid Vere (Rice) at the Mill for work experience.

| rowspan="3" | 18 March

| Sophie Ford{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Jimmi Clay makes a SHOCK discovery! |url=https://www.whatsontv.co.uk/events/doctors-spoilers-jimmi-clay-shock-discovery/ |access-date=18 March 2021 |work=What's on TV |publisher=Future plc |archive-date=15 March 2021 |archive-url=https://web.archive.org/web/20210315212218/https://www.whatsontv.co.uk/events/doctors-spoilers-jimmi-clay-shock-discovery/ |url-status=live }}

| A teenager who gives up studying nursing at university in order to care for Graham (Jonty Stephens), her father with dementia.

| Jonty Stephens

| A man with dementia. He is cared for by daughter Evie (Sophie Ford).

| April Pearson

| Evie Steele's (Ford) sister. Evie discovers that Chloe once had an opportunity to put their father in a care home, but declined due to the cost of his treatment.

| rowspan="3" | 22 March

| Marina Manoharan{{cite news |last1=Timblick |first1=Simon |url=https://www.whatsontv.co.uk/events/doctors-spoilers-wendi-peters-guest-stars/ |title=Doctors spoilers: Ex-Corrie star Wendi Peters (aka Cilla) guest stars |access-date=23 March 2021 |work=What's on TV |publisher=Future plc |archive-date=28 April 2021 |archive-url=https://web.archive.org/web/20210428175933/https://www.whatsontv.co.uk/events/doctors-spoilers-wendi-peters-guest-stars/ |url-status=live }}

| A woman who attends Zara Carmichael (Walsh) and Emma Reid's (Miles) menopause support group despite being post-menopausal.

| Wendi Peters

| A woman who attends Zara Carmichael (Walsh) and Emma Reid's (Miles) menopause support group due to having heightened anger.

| Helene Maksoud

| A woman who attends Zara Carmichael (Walsh) and Emma Reid's (Miles) menopause support group due to feeling ugly.

| rowspan="3" | 23 March

| Steven Hillman{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Can Daniel Granger save Matthew Portman? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-daniel-granger-save-matthew-portman/ |access-date=23 March 2021 |work=What's on TV |publisher=Future plc |archive-date=23 March 2021 |archive-url=https://web.archive.org/web/20210323065251/https://www.whatsontv.co.uk/events/doctors-spoilers-daniel-granger-save-matthew-portman/ |url-status=live }}

| A man who reunites with his brother Jeff (Stephen Bent) after living in Spain for 15 years.

| Stephen Bent

| A man who is targeted by a local gang on his estate.

| Dillon Scott-Lewis

| A gang leader who targets Jeff Sewell (Bent).

| 24 March–19 May

| John Leader{{Cite episode|title=You Win Some|url=https://www.bbc.co.uk/programmes/m000tjd9|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|air-date=24 March 2021|access-date=24 March 2021|archive-date=24 March 2021|archive-url=https://web.archive.org/web/20210324114451/https://www.bbc.co.uk/programmes/m000tjd9|url-status=live}}

| A friend of Sid Vere (Rice) who asks him to get involved in his fundraising activities for a meningitis charity since they were both affected by the disease in their childhood. After hosting the final charity event, Lewis feels tired and returns home. He then dies from a heart arrhythmia.

| rowspan="3" | 24 March

| Maxine Finch

| A woman who saves money for over ten years to visit her estranged family in Zimbabwe. She learns that her husband John (Andrew Lewis), a gambling addict, has used all of her saved money.

| Andrew Lewis

| A gambling addict who uses his wife's savings to fund daughter Selina's (Mica Ricketts) business, as well as gambling.

| Mica Ricketts

| The daughter of Taya (Finch) and John Barnett (Lewis). She pleads with John to lend her money to fund her business proposal, which fails.

| rowspan="3" | 25 March

| Enzo Squillino Jr.

| The father of Adam (Matthew Marcelis) who refuses to believe that he has schizophrenia like his mother.

| Matthew Marcelis

| A university graduate who suffers from the symptoms of schizophrenia.

| Helen Sheals

| The schizophrenic mother of Adam Loreto (Marcelis).

| rowspan="3" | 29 March

| Ross Gilby{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Miranda Evans impress the surgery staff? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-miranda-evans-impress-surgery-staff/ |access-date=29 March 2021 |work=What's on TV |publisher=Future plc |archive-date=26 March 2021 |archive-url=https://web.archive.org/web/20210326100830/https://www.whatsontv.co.uk/events/doctors-spoilers-miranda-evans-impress-surgery-staff/ |url-status=live }}

| An ex-convict who spends time with Patricia Stanton (Clare Clifford) since she is elderly and lonely. When she attempts to kill herself with a knife, Rob Hollins (Walker) assumes Andy has tried to kill her for money.

| Ryan Cloud

| The great-nephew of Patricia Stanton (Clifford).

| Clare Clifford

| An elderly woman who tries to kill herself due to loneliness.

| rowspan="3" | 30 March

| Marc Butters{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Al Haskey has created a new game app! |url=https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-new-game-app/ |access-date=30 March 2021 |work=What's on TV |publisher=Future plc |archive-date=30 March 2021 |archive-url=https://web.archive.org/web/20210330190900/https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-new-game-app/ |url-status=live }}

| A young police officer who accidentally stabs and kills an abuser.

| Tim Treloar

| A retiring police officer who tries to cover for Marc Wilcox's (Marc Butters) accident.

| Victor Gardener

| Marc Wilcox's (Butters) father who tries to bribe his bosses in order to protect Marc's career.

| rowspan="2" | 31 March

| Elizabeth Cadwallader{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Tragedy for Rumha Carter in FLASHBACK episode |url=https://www.whatsontv.co.uk/events/doctors-spoilers-tragedy-ruhma-carter-flashback-episode/ |access-date=1 April 2021 |work=What's on TV |publisher=Future plc |archive-date=31 March 2021 |archive-url=https://web.archive.org/web/20210331180745/https://www.whatsontv.co.uk/events/doctors-spoilers-tragedy-ruhma-carter-flashback-episode/ |url-status=live }}

| A patient of Ruhma Carter's (Patel) who has two miscarriages. After going on the pill, she accidentally gets pregnant and gives birth.

| Lloyd Thomas

| The husband of Kate (Elizabeth Cadwallader) who struggles to cope with the couple's two miscarriages.

| rowspan="3" | 1 April

| Martyn Ellis{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Al Haskey hosts a shared patient consultation |url=https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-shared-patient-consultation/ |access-date=1 April 2021 |work=What's on TV |publisher=Future plc |archive-date=1 April 2021 |archive-url=https://web.archive.org/web/20210401090633/https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-shared-patient-consultation/ |url-status=live }}

| A radio broadcaster who struggles with high blood pressure. He attends a group consultation with Al Haskey (Midlane), who advises him to make a follow-up appointment.

| Rachel Lin

| A graphic novelist who attends a group consultation with Al Haskey (Midlane) after suffering from high blood pressure caused by her job.

| Steven Meo

| A man who attends a group consultation with Al Haskey (Midlane) due to suffering from high blood pressure caused by his abusive girlfriend. Fellow attendee Carrie Kwouk (Rachel Lin) encourages him to leave her.

| rowspan="4" | 19 April

| Rachel Denning{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Valerie Pitman has a cancer SCARE... |url=https://www.whatsontv.co.uk/events/doctors-spoilers-valerie-pitman-cancer-scare/ |access-date=19 April 2021 |work=What's on TV |publisher=Future plc |archive-date=19 April 2021 |archive-url=https://web.archive.org/web/20210419141154/https://www.whatsontv.co.uk/events/doctors-spoilers-valerie-pitman-cancer-scare/ |url-status=live }}

| A woman with dwarfism who discovers that rugby player Jake Ashcroft (Chris Eastwood) had sex with her to be initiated into his rugby team. She exposes him to his pregnant girlfriend by pretending she has given him chlamydia.

| Chris Eastwood

| A man who sex with Alison Murray (Rachel Denning) to be initiated into his rugby team. He confesses to pregnant girlfriend Lauren Jones (Natalie O'Neill) since he believes Alison has given him chlamydia.

| Natalie O'Neill

| A pregnant woman who learns that her boyfriend has cheated on her and may have given her chlamydia. She later leaves him.

| Andrea Crewe

| An oncologist who informs Valerie Pitman (Moyle) that she may have cancer again. She books her in for a scan.

| rowspan="2" | 20 April

| Nicky Goldie

| A former children's home matron who has her dog killed by Kevin Newly (Josef Hyland) as revenge for her ignoring him being sexually abused in the home as a child.

| Josef Hyland

| A man who was sexually abused as a child whilst staying in a children's home. He poisons Connie Hinkley's (Nicky Goldie) dog as revenge, since she was the matron and ignored what was happening.

| rowspan="4" | 21 April

| Simon Poland{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Car wash DRAMA for Ruhma Carter and co! |url=https://www.whatsontv.co.uk/events/doctors-spoilers-car-wash-drama-ruhma-carter/ |access-date=22 April 2021 |work=What's on TV |publisher=Future plc |archive-date=28 April 2021 |archive-url=https://web.archive.org/web/20210428175905/https://www.whatsontv.co.uk/events/doctors-spoilers-car-wash-drama-ruhma-carter/ |url-status=live }}

| A priest who, after the death of his partner, decides he does not want to fight his illness. Luca McIntyre (McLaren) encourages him to take treatment.

| Joeraver Sangha

| A man with testicular cancer who calls off his wedding as he is scared about informing his fiancée about his diagnosis.

| Bella Hamblin

| A woman who ends her marriage with husband Simon (Sean Connolly) after discovering his various affairs.

| Sean Connolly

| A theatre actor who cheats on wife Judith (Bella Hamblin) with various women at his shows.

| rowspan="3" | 22 April

| Graham Bryan

| A man who has cheated on wife Sue (Cindy Humphrey) with Brittany Paddock (Sally Mason); he later decides he wants Sue back. He is dumped by both women.

| Cindy Humphrey

| The neighbour of Karen Hollins (Pearson) whose husband has cheated on her.

| Sally Mason

| The new wife of Thomas Kaplan (Graham Bryan) who dumps him when she discovers that he wants his old wife back.

| 26–27 April

| Luke Grant{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: SURPRISE news for Valerie Pitman! |url=https://www.whatsontv.co.uk/events/doctors-spoilers-surprise-news-valerie-pitman/ |access-date=26 April 2021 |work=What's on TV |publisher=Future plc |archive-date=26 April 2021 |archive-url=https://web.archive.org/web/20210426144148/https://www.whatsontv.co.uk/events/doctors-spoilers-surprise-news-valerie-pitman/ |url-status=live }}

| A man that Luca McIntyre (McLaren) meets through a dating app and goes on a date with. When he gets too drunk on the date, he accidentally headbutts Luca when trying to give him a hug.

| rowspan="4" | 26 April

| Ryan Dean

| A 21-year-old who ends up in prison after dreaming of becoming a footballer.

| Robert Boulter

| A documentary maker who includes Josh Brooks (Ryan Dean) and Bradley Preston (Kwame Kandekore) in his documentary.

| Caroline Parker

| A prison guard who expresses a dislike in both the prisoners and her job.

| Kwame Kandekore

| A friend of Josh Brooks (Dean) who becomes a footballer.

| rowspan="3" | 28 April

| Elizabeth Elvin

| A woman that Valerie Pitman (Moyle) visits after discovering a photo of a young child in front of Maureen's house.

| Tyler Blythin

| A man with a stammer that witnesses his friend, Drew Worth (Jamie O'Neill), get attacked for defending him.

| Jamie O'Neill

| A man who gets attacked after defending his friend, Martin Worth (Tyler Blythin), who has a stammer.

| rowspan="3" | 29 April

| Melanie Gutteridge

| The mother of Jemma (Erin Grace), who learns that she has an atrial myxoma. Rachel puts her into contact with her estranged father.

| Erin Grace

| The daughter of Rachel who, after 26 years, is put into contact with her father, Dave Mercer (Rufus Wright).

| Rufus Wright

| The estranged father of Jemma Coleman (Erin Grace). He assures her that he has wanted to be in contact with her for years.

| rowspan="3" | 4 May

| Sarah Thom{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Jimmi Clay helps a family deal with a cancer diagnosis |url=https://www.whatsontv.co.uk/events/doctors-spoilers-jimmi-clay-family-cancer-diagnosis/ |access-date=4 May 2021 |work=What's on TV |publisher=Future plc |archive-date=30 April 2021 |archive-url=https://web.archive.org/web/20210430175313/https://www.whatsontv.co.uk/events/doctors-spoilers-jimmi-clay-family-cancer-diagnosis/ |url-status=live }}

| The daughter of Sally (Bebe Sanders) who takes a job in Malaysia. When she learns that her mother is dying from cancer, she visits her to say goodbye alongside her brother.

| Michael Jinks

| The son of Sally (Sanders) who takes care of her until she dies of cancer.

| Bebe Sanders

| A friend of Jimmi Clay's (Morgan) who is treated by him for over ten years. She is diagnosed with colon cancer, and despite being cured numerous times, it eventually spreads to her spine, lungs and brain. She eventually dies in hospital.

| rowspan="3" | 5 May

| Corey Trevor{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Valerie Pitman QUIT her job? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-valerie-pitman-quit-job/ |access-date=5 May 2021 |work=What's on TV |publisher=Future plc |archive-date=3 May 2021 |archive-url=https://web.archive.org/web/20210503035230/https://www.whatsontv.co.uk/events/doctors-spoilers-valerie-pitman-quit-job/ |url-status=live }}

| An ex-convict who cares for his grandmother, Hannah (Angela Curran). Hannah gives him the deed to her house on her deathbed.

| Angela Curran

| The grandmother of Darren (Corey Trevor) who suffers from dementia. On her deathbed, she gives the deeds to her house to Darren with police officers Rob Hollins (Walker) and Harriet Shelton (Carley Stenson) acting as their witnesses.

| Demelza O'Sullivan

| The daughter of Hannah (Curran), who taught her shoplifting techniques.

| 6–27 May

| James Barriscale{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Al Haskey be a WINNER on Sports Day? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-winner-sports-day/ |access-date=8 May 2021 |work=What's on TV |publisher=Future plc |archive-date=9 May 2021 |archive-url=https://web.archive.org/web/20210509062029/https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-winner-sports-day/ |url-status=live }}

| A man who appeared in a photograph as a child, which is found by Valerie Pitman (Moyle). When she arrives at his house to tell him about her findings, he dismisses her. The next day, he visits the Mill to apologise to Valerie. The pair agree to go on a date and begin dating, but Nathan is dismayed when Valerie tells him that she is looking for adventure and that he is too boring for her.

| rowspan="3" | 6 May

| Jennie Dale

| rowspan="3" | Three chefs who compete against Ruhma Carter (Patel), Al Haskey (Midlane) and Sid Vere (Rice) in a sports day organised by Lewis Ainsley (John Leader) to raise money for a meningitis charity.

| Adaya Henry

| Elizabeth Hill

| rowspan="3" | 10 May

| Andrew Langtree{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO is the unexpected visitor at the Mill? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-who-is-unexpected-visitor-the-mill/ |access-date=10 May 2021 |work=What's on TV |publisher=Future plc |archive-date=7 May 2021 |archive-url=https://web.archive.org/web/20210507203617/https://www.whatsontv.co.uk/events/doctors-spoilers-who-is-unexpected-visitor-the-mill/ |url-status=live }}

| A man with agoraphobia caused by both the death of his brother and the COVID-19 pandemic.

| Sarah Middleton

| The sister of Patrick (Andrew Langtree) who pretends to have stomach cancer in order to help him combat his agoraphobia.

| Neil Paul

| A childhood friend of Lynda Barclay (Sarah Middleton) who is disgusted with her when she lies about having stomach cancer.

| rowspan="4" | 11 May

| Gemma Page{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Ex-EastEnders star Aaron Sidwell guests |url=https://www.whatsontv.co.uk/events/doctors-spoilers-ex-eastenders-star-aaron-sidwell/ |access-date=11 May 2021 |work=What's on TV |publisher=Future plc |archive-date=11 May 2021 |archive-url=https://web.archive.org/web/20210511152845/https://www.whatsontv.co.uk/events/doctors-spoilers-ex-eastenders-star-aaron-sidwell/ |url-status=live }}

| The birth mother of Nathan Sallery (James Barriscale) who suffers from memory loss due to having undergone electroshock therapy in her youth.

| Michael Kirk

| The husband of Barbara (Gemma Page) who has cared for her throughout their marriage.

| Aaron Sidwell

| The expecting father of Charmaine's (Tricia Adele-Turner) baby who runs an online video channel.

| {{nowrap|Tricia Adele-Turner}}

| The pregnant wife of Joel (Aaron Sidwell) who learns that their child will be born with a disability.

| rowspan="3" | 12 May

| Anna Acton{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Is there romance in store for Al Haskey? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-romance-in-store-al-haskey/ |access-date=12 May 2021 |work=What's on TV |publisher=Future plc |archive-date=12 May 2021 |archive-url=https://web.archive.org/web/20210512151723/https://www.whatsontv.co.uk/events/doctors-spoilers-romance-in-store-al-haskey/ |url-status=live }}

| A woman who goes on a date with Al Haskey (Ian Midlane). He later realises that she pretended to be his real date, and questions her, where Vicki reveals that she routinely pretends to be other people to escape a mundane life.

| Amey Woodhall

| The friend of Vicki (Anna Acton) who gets too drunk in a bar owned by TK Nelson (Adam Deacon).

| Adam Deacon

| The owner of a bar who challenges Al Haskey (Midlane) to a bet which Al wins.

| rowspan="3" | 13 May

| Mark Sheals{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Sid Vere must decide on the FINAL charity challenge! |url=https://www.whatsontv.co.uk/events/doctors-spoilers-sid-vere-final-charity-challenge/ |access-date=13 May 2021 |work=What's on TV |publisher=Future plc |archive-date=13 May 2021 |archive-url=https://web.archive.org/web/20210513065409/https://www.whatsontv.co.uk/events/doctors-spoilers-sid-vere-final-charity-challenge/ |url-status=live }}

| A prisoner at HMP Letherbridge who is set to be released the following week.

| Khalid Daley

| A prisoner at HMP Letherbank who receives help from Daniel Granger (Matthew Chambers) concerning being bullied in prison.

| Joshua Osei

| A prisoner at HMP Letherbank who tries to make Craig Emerson (Khalid Daley) smuggle drugs into the prison.

| rowspan="3" | 17 May

| Thapelo Ray{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Valerie Pitman has a date tonight! |url=https://www.whatsontv.co.uk/events/doctors-spoilers-valerie-pitman-date-tonight/ |access-date=17 May 2021 |work=What's on TV |publisher=Future plc |archive-date=14 May 2021 |archive-url=https://web.archive.org/web/20210514115209/https://www.whatsontv.co.uk/events/doctors-spoilers-valerie-pitman-date-tonight/ |url-status=live }}

| A teenager who dislikes his mother's new partner since he is enabling her drug addiction.

| Adrienne Grant

| A woman who is groomed into a drug addiction by drug dealer Byron Hall (James Palmer).

| James Palmer

| A drug dealer who grooms Sasha Norris (Adrienne Grant) into forming a drug addiction.

| rowspan="4" | 18 May

| Liam Ainsworth{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Is Rob Hollins hiding a SECRET from Karen? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-rob-hollins-hiding-secret-karen/ |access-date=18 May 2021 |work=What's on TV |publisher=Future plc |archive-date=18 May 2021 |archive-url=https://web.archive.org/web/20210518101945/https://www.whatsontv.co.uk/events/doctors-spoilers-rob-hollins-hiding-secret-karen/ |url-status=live }}

| A man who is undergoing "superhero therapy" with therapist Philip Laws (Adam Ewan) since he accidentally killed the parents of Stephen Powers (Sam C Wilson) whilst drunk driving.

| Adam Ewan

| A therapist who offers "superhero therapy" to Matthew Wargate (Liam Ainsworth). Al Haskey (Midlane) criticises his professionalism since he takes two-day courses to keep up with therapy trends.

| Paul Jerricho

| An elderly man who is visited biweekly by care volunteer Matthew Wargate (Ainsworth).

| Sam C Wilson

| A man who grew up in foster care due to Matthew Wargate (Liam Ainsworth) killing his parents whilst drunk driving.

| rowspan="2" | 19 May

| Kezia Burrows{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHAT do Sid Vere and Rob Hollins discover? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-sid-vere-rob-hollins-discover/ |access-date=20 May 2021 |work=What's on TV |publisher=Future plc |archive-date=19 May 2021 |archive-url=https://web.archive.org/web/20210519193610/https://www.whatsontv.co.uk/events/doctors-spoilers-sid-vere-rob-hollins-discover/ |url-status=live }}

| A patient of Sid Vere's (Rice) who has recently split from her abusive husband. Her friend Ashley Kershaw (Poppy Roe) attempts to set her up on a date with both Sid and Lewis Ainsley (John Leader).

| Poppy Roe

| A friend of Kelly Beck's (Kezia Burrows) who attempts to set her up on dates following Kelly's split from her husband.

| rowspan="3" | 20 May

| Ruben Crow{{Cite episode|title=Into the Woods|url=https://www.bbc.co.uk/programmes/m000w811|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|air-date=20 May 2021|access-date=6 June 2021|archive-date=20 May 2021|archive-url=https://web.archive.org/web/20210520185910/https://www.bbc.co.uk/programmes/m000w811|url-status=live}}

| rowspan="2" | A married couple who have several arguments and decide to split up whilst on a survival course with Alec Dearmer (Fin Gardner).

| Zannah Hodson

| Fin Gardner

| A survival course instructor who hosts a course with Valerie Pitman (Sarah Moyle), Nathan Sallery (James Barriscale) and the Hodgsons.

| rowspan="4" | 25 May

| Delroy Brown{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Luca McIntyre find missing Jonno Parker? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-luca-mcintyre-missing-jonno-parker/ |access-date=27 May 2021 |work=What's on TV |publisher=Future plc |archive-date=25 May 2021 |archive-url=https://web.archive.org/web/20210525120641/https://www.whatsontv.co.uk/events/doctors-spoilers-luca-mcintyre-missing-jonno-parker/ |url-status=live }}

| A friend of Al Haskey's (Midlane) who calls Al to fix the internet connection at his workplace. Al encourages him to ask Liv Keane (Elinor Lawless) on a date.

| Elinor Lawless

| A gardener working at Ed Benson's (Delroy Brown) workplace; the two form a romantic connection and agree to go on a date.

| Damien James

| The son of Liv (Lawless) who has a talent for computing.

| Elliot Rodriguez

| A friend of Jonno Parker's (Tommy Sim'aan). He does not allow Jonno to stay at his house while on drugs since he has a wife and kids.

| 26 May

| Graeme Brookes{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Zara Carmichael gets TRAPPED in her car! |url=https://www.whatsontv.co.uk/events/doctors-spoilers-zara-carmichael-trapped-in-car/ |access-date=27 May 2021 |work=What's on TV |publisher=Future plc |archive-date=26 May 2021 |archive-url=https://web.archive.org/web/20210526202221/https://www.whatsontv.co.uk/events/doctors-spoilers-zara-carmichael-trapped-in-car/ |url-status=live }}

| A man who tries to help Zara Carmichael (Walsh) out of her car when she gets locked inside.

| rowspan="3" | 27 May

| Jasmine Armfield{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Sid Vere attend Lewis's wake? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-will-sid-vere-attend-wake/ |access-date=27 May 2021 |work=What's on TV |publisher=Future plc |archive-date=18 May 2021 |archive-url=https://web.archive.org/web/20210518080644/https://www.whatsontv.co.uk/events/doctors-spoilers-will-sid-vere-attend-wake/ |url-status=live }}

| A vegan activist who discovers her boyfriend, Tom Ashwood (Loris Scarpa), is in debt and has a drug addicted mother.

| Loris Scarpa

| The boyfriend of Layla Roberts (Jasmine Armfield) who reveals that his mother is addicted to drugs and that he is in a lot of debt. Jimmi Clay (Morgan) gives him a scratchcard that he won £5000 on in order for Tom to pay his debts off.

| Karlina Grace-Paseda

| The mother of Lewis (Leader) who invites his friend, Sid Vere (Rice), to Lewis' wake following his death.

| rowspan="3" | 1 June

| Ruby-May Martinwood{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Things get FLIRTY for Rob Hollins! |url=https://www.whatsontv.co.uk/events/doctors-spoilers-things-get-flirty-rob-hollins/ |access-date=2 June 2021 |work=What's on TV |publisher=Future plc |archive-date=30 May 2021 |archive-url=https://web.archive.org/web/20210530224229/https://www.whatsontv.co.uk/events/doctors-spoilers-things-get-flirty-rob-hollins/ |url-status=live }}

| A teenage patient of Ruhma Carter's (Patel) who is pregnant. Her family and friends do not know of the baby until classmate Mason Higgs (Billy Angel) accidentally tells her father.

| Christopher Sciueref

| The father of Amy (Ruby-May Martinwood).

| Billy Angel

| A classmate of Amy Papoutsis' (Ruby-May Martinwood) who accomanies her to her hospital appointment.

| rowspan="4" | 2 June

| James Teague{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Can Al Haskey help an awkward family reunion? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-help-family-reunion/ |access-date=2 June 2021 |work=What's on TV |publisher=Future plc |archive-date=30 May 2021 |archive-url=https://web.archive.org/web/20210530224339/https://www.whatsontv.co.uk/events/doctors-spoilers-al-haskey-help-family-reunion/ |url-status=live }}

| A teenager suffering from grief after the death of his mother.

| Ian Hallard

| The father of Ryan (James Teague) and a Letherbridge councillor that works with Al Haskey (Midlane).

| Dayna Bateman

| A teenager who lives in a youth hostel due to her tumultuous relationship with her mother.

| Susie Riddell

| The mother of Hayley (Dayna Bateman) who meets with Al Haskey (Midlane) and Bear Sylvester (Lee) when she goes missing.

| 3 June

| Samantha Robinson{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: What is WRONG with Rob Hollins? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-what-is-wrong-rob-hollins/ |access-date=3 June 2021 |work=What's on TV |publisher=Future plc |archive-date=3 June 2021 |archive-url=https://web.archive.org/web/20210603174921/https://www.whatsontv.co.uk/events/doctors-spoilers-what-is-wrong-rob-hollins/ |url-status=live }}

| The colleague and girlfriend of Barry Biglow (David Perks) who has an overly high sex drive. The pair see Emma Reid (Miles) as Barry is unable to keep up with Becky and Emma informs her that her increased sex drive is due to her recent antidepressants prescription.

| rowspan="3" | 4 June

| Alice Henley{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: WHO does Sid Vere get flirty with? |url=https://www.whatsontv.co.uk/events/doctors-spoilers-who-does-sid-vere-flirty-with/ |access-date=6 June 2021 |work=What's on TV |publisher=Future plc |archive-date=3 June 2021 |archive-url=https://web.archive.org/web/20210603080828/https://www.whatsontv.co.uk/events/doctors-spoilers-who-does-sid-vere-flirty-with/ |url-status=live }}

| A contestant in Sid Vere's (Rice) treasure hunt. She is accompanied by her friend Will Gould (Darren Hart). She later reveals to him that Stuart Mangold (Simon Tcherniak) sexually assaulted her.

| Darren Hart

| A friend of Bella Bentley's (Alice Henley) who accompanies her to a treasure hunt.

| Simon Tcherniak

| An NHS boardman who meets with Bear Sylvester (Lee) to discuss the wellbeing of an overweight patient who needs an operation. He is impressed by Bear's debating skills and says he would fit in well with the panel, but when Bear learns that Stuart has sexually assaulted Bella Bentley (Henley), he threatens to expose Stuart.

| rowspan="4" | 7 June

| Himself{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Guest appearance by ex-Hollyoaks star Nathan Sussex |url=https://www.whatsontv.co.uk/events/doctors-spoilers-guest-appearance-ex-hollyoaks-star-nathan-sussex/ |access-date=7 June 2021 |work=What's on TV |publisher=Future plc |archive-date=5 June 2021 |archive-url=https://web.archive.org/web/20210605123658/https://www.whatsontv.co.uk/events/doctors-spoilers-guest-appearance-ex-hollyoaks-star-nathan-sussex/ |url-status=live }}

| An interviewer who interviews Sid Vere (Rice) about his efforts for a meningitis charity.

| Nathan Sussex

| A widower who is suffering from stress and potential prostate cancer.

| Jon-Paul Bell

| The adoptive son of Alan Carling (Nathan Sussex) who worries about his health after losing his other adoptive father.

| Catrin Powell

| The unreliable sister of Alan Carling (Sussex) who he kicks out.

| rowspan="2" | 8 June

| Leslie Ash{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Guest appearance by Holby City star Leslie Ash |url=https://www.whatsontv.co.uk/events/doctors-spoilers-guest-appearance-leslie-ash/ |access-date=9 June 2021 |work=What's on TV |publisher=Future plc |archive-date=9 June 2021 |archive-url=https://web.archive.org/web/20210609143529/https://www.whatsontv.co.uk/events/doctors-spoilers-guest-appearance-leslie-ash/ |url-status=live }}

| A woman who discovers that a man she loved had several affairs following his death.

| Buffy Davis

| The wife of a man who has recently died. She informs Mary McRae (Leslie Ash), one of his affair partners, that he had several affairs through her marriage to him.

| rowspan="3" | 9 June

| Rachel Bruce{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: DRUNK on the job?... Sid Vere gets breathalysed! |url=https://www.whatsontv.co.uk/events/doctors-spoilers-sid-vere-gets-breathalysed/ |access-date=9 June 2021 |work=What's on TV |publisher=Future plc |archive-date=9 June 2021 |archive-url=https://web.archive.org/web/20210609113638/https://www.whatsontv.co.uk/events/doctors-spoilers-sid-vere-gets-breathalysed/ |url-status=live }}

| A university student who acquires medication from Al Haskey (Midlane) so that she can drug Jacob Willis (James McDowall) as revenge for hosting a competition to have sex with her. She burns his clothes and takes photos of him in poorly done makeup to humiliate him.

| James McDowall

| A university student who competes with other students to see who can have sex with the "poorest girl on campus", Marie Scally (Rachel Bruce).

| Zheng Xi Yong

| The friend of Jacob Willis (McDowall) who believes his treatment of women is poor.

| {{nowrap|9 June, 20 October}}

| Elexi Walker

| The boss of Sid Vere (Rice) who sends him home from a rapid response shift for being drunk.

| rowspan="4" | 10 June

| Jo Richards{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Al Haskey cause a DISASTER for Bear Sylvester? |url=https://www.whattowatch.com/events/doctors-spoilers-al-haskey-disaster-bear-sylvester |access-date=11 June 2021 |work=What to Watch |publisher=Future plc |archive-date=11 June 2021 |archive-url=https://web.archive.org/web/20210611083419/https://www.whattowatch.com/events/doctors-spoilers-al-haskey-disaster-bear-sylvester |url-status=live }}

| A gardener who has violent tendencies towards her daughter Ruby (Ruby Richards).

| Ruby Richards

| The daughter of Joanna (Jo Richards) who gets excluded from school for being repeatedly late.

| William Hayes

| The boss of Joanna Jacobs (Richards) who allows her time off after an injury, giving her shifts to her troublesome daughter Ruby (Richards).

| Steve Giles

| An accountant who Bear Sylvester (Lee) attends an online audit meeting with.

| rowspan="2" | 11 June

| Ian Weichardt{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Luca McIntyre suspects a case of domestic violence... |url=https://www.whattowatch.com/events/doctors-spoilers-luca-mcintyre-suspects-domestic-violence |access-date=11 June 2021 |work=What to Watch |publisher=Future plc |archive-date=11 June 2021 |archive-url=https://web.archive.org/web/20210611211119/https://www.whattowatch.com/events/doctors-spoilers-luca-mcintyre-suspects-domestic-violence |url-status=live }}

| A colon cancer survivor who is being abused by his girlfriend Moira Cole (Crystal Condie). Luca McIntyre (McLaren) helps him to realise that Moria's treatment of him is abuse and encourages Ben to leave her when he feels ready.

| Crystal Condie

| The abusive girlfriend of Ben Harrison (Ian Weichardt).

| rowspan="2" | 15 June

| Matt Tait{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Marriage trouble for Karen and Rob Hollins |url=https://www.whattowatch.com/events/doctors-spoilers-marriage-trouble-karen-rob-hollins |access-date=15 June 2021 |work=What to Watch |publisher=Future plc |archive-date=24 June 2021 |archive-url=https://web.archive.org/web/20210624143717/https://www.whattowatch.com/events/doctors-spoilers-marriage-trouble-karen-rob-hollins |url-status=live }}

| The husband of Zoe (Lizzie Stables) who calls Ruhma Carter (Patel) when he fears she has relapsed into her psychosis.

| Lizzie Stables

| A new mother who mistakes a vision problem for a psychosis relapse.

| rowspan="3" | 17 June

| {{nowrap|Maeve Courtier-Lilley{{cite news |last1=Timblick |first1=Simon |title=Doctors spoilers: Will Sid Vere impress with his presentation? |url=https://www.whattowatch.com/events/doctors-spoilers-will-sid-vere-impress-presentation |access-date=22 June 2021 |work=What to Watch |publisher=Future plc |archive-date=24 June 2021 |archive-url=https://web.archive.org/web/20210624143719/https://www.whattowatch.com/events/doctors-spoilers-will-sid-vere-impress-presentation |url-status=live }}}}

| The 16-year-old sister of Duncan (Jack Carroll) who suffers from endometriosis. She uses his dating app account to pay Jason Duquette (Jon Glasgow) to have sex with Duncan since she pities him for being a virgin.

| Jack Carroll

| A virgin who is advised by McIntyre (McLaren) to meet people in person as opposed to using dating apps.

| Jon Glasgow

| A sex worker who is paid by Sophia Wheatley (Maeve Courtier-Lilley) to have sex with her brother.

| rowspan="3" | 21 June

| Simon Wilson{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Karen Hollins confronts Rob and Harriet! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-karen-hollins-confronts-rob-and-harriet |access-date=22 June 2021 |work=What to Watch |publisher=Future plc |archive-date=24 June 2021 |archive-url=https://web.archive.org/web/20210624143713/https://www.whattowatch.com/spoilers/doctors-spoilers-karen-hollins-confronts-rob-and-harriet |url-status=live }}

| A hospital surgeon who opens up to Daniel Granger (Chambers) about his suicidal thoughts following the rise of deaths of patients during the COVID-19 pandemic.

| Felicity Green

| The daughter of Rich (Simon Wilson) who contacts his ex-partner Judy Sutton (Bridgitta Roy) when she learns of his suicidal thoughts.

| Bridgitta Roy

| The ex-partner of Rich Marshall (Wilson) who lends her support when she learns of his suicidal thoughts.

| rowspan="2" | 22 June

| Rebecca Bainbridge{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Karen and Rob Hollins have a BIG argument! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-karen-and-rob-hollins-have-a-big-argument |access-date=24 June 2021 |work=What to Watch |publisher=Future plc |archive-date=24 June 2021 |archive-url=https://web.archive.org/web/20210624143659/https://www.whattowatch.com/spoilers/doctors-spoilers-karen-and-rob-hollins-have-a-big-argument |url-status=live }}

| A violinist that Ruhma Carter (Patel) recognises from when she performed for her and her dead husband Heston (Owen Brenman).

| Lloyd Gorman

| A violinist who performs with Ginny Redman (Rebecca Bainbridge).

| rowspan="4" | 23 June

| Ben Moor{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Valerie Pitman in Wonderland! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-in-wonderland |access-date=24 June 2021 |work=What to Watch |publisher=Future plc |archive-date=24 June 2021 |archive-url=https://web.archive.org/web/20210624143656/https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-in-wonderland |url-status=live }}

| The brother of Hattie (Harriet Thorpe) who gives Valerie Pitman (Moyle) a rock painted like a ladybird.

| Harriet Thorpe

| The owner of a field where Valerie Pitman (Moyle) stays. She pushes Valerie to leave.

| Helen Lederer

| A birdwatcher at a lake where Valerie Pitman (Moyle) visits.

| Ian Midlane

| Valerie Pitman's (Moyle) dead cat who visits her in a dream to advise her on her future.

| {{nowrap|24 June–9 September}}

| Zak Douglas{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Rob Hollins SNAPS! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-rob-hollins-snaps |access-date=24 June 2021 |work=What to Watch |publisher=Future plc |archive-date=24 June 2021 |archive-url=https://web.archive.org/web/20210624143715/https://www.whattowatch.com/spoilers/doctors-spoilers-rob-hollins-snaps |url-status=live }}

| A criminal who taunts Rob Hollins (Walker) after Rob cannot catch him for trespassing in a community building. Harriet Shelton (Stenson) finds him lifeless at the bottom of a staircase, with Rob standing over him. When he awakens from his unconscious state, he is questioned by Inspector Zoya Okoro (Donna Berlin) and tells her that Rob is responsible for his fall.

| rowspan="2" | 24 June

| Lewis Conway

| The criminal friend of Aaron Jeffries (Zak Douglas) who escapes before he is caught by the police.

| Nicholas Chambers

| A man whose bike is nearly stolen by Aaron Jeffries (Douglas) and Lenny Calhoun (Nicholas Chambers).

| 6–27 September

| Donna Berlin{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Has Rob Hollins KILLED bad boy Aaron? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-has-rob-hollins-killed-bad-boy-aaron |access-date=6 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=15 September 2021 |archive-url=https://web.archive.org/web/20210915093041/https://www.whattowatch.com/spoilers/doctors-spoilers-has-rob-hollins-killed-bad-boy-aaron |url-status=live }}

| An inspector who investigates a case where Aaron Jeffries (Douglas) is found unconscious at the bottom of a flight of stairs.

| rowspan="2" | 6 September

| Ashley Campbell

| The fashion designer son of Isabel (Judy Clifton) who persuades Emma Reid (Miles) to buy a dress from him.

| Judy Clifton

| The mother of Andrew (Ashley Campbell) who refuses to part with her favourite chair.

| rowspan="2" | 7 September

| Tim Preston{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Will Aaron Jeffries reveal the TRUTH? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-aaron-jeffries-reveal-the-truth |access-date=10 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=15 September 2021 |archive-url=https://web.archive.org/web/20210915093043/https://www.whattowatch.com/spoilers/doctors-spoilers-will-aaron-jeffries-reveal-the-truth |url-status=live }}

| A medical student who confronts famous anti-vaxxer Sarah Franks (Lola-Rose Maxwell) regarding her attitudes towards vaccines.

| Lola-Rose Maxwell

| An actress who is popular online, where she posts videos about her vaccine hesitancy.

| rowspan="3" | 8 September

| Dominic Geraghty{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: WHO puts Al Haskey in a grumpy mood? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-puts-al-haskey-in-a-grumpy-mood |access-date=10 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=15 September 2021 |archive-url=https://web.archive.org/web/20210915093036/https://www.whattowatch.com/spoilers/doctors-spoilers-who-puts-al-haskey-in-a-grumpy-mood |url-status=live }}

| A handyman who saves the life of Lulu Ronson (Emily Drewett) after finding her collapsed inside of her university accommodation.

| Michele Moran

| The housing officer of Letherbridge University who neglects students including asthmatic Lulu Ronson (Drewett).

| Emily Drewett

| An asthmatic patient of Al Haskey's (Midlane) who sees him about struggling to breathe due to the mould and damp walls in her university accommodation being a trigger for her asthma.

| 9 September

| Laura Doddington{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Can Daniel Granger diagnose Rob Hollins? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-can-daniel-granger-diagnose-rob-hollins |access-date=10 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=15 September 2021 |archive-url=https://web.archive.org/web/20210915093040/https://www.whattowatch.com/spoilers/doctors-spoilers-can-daniel-granger-diagnose-rob-hollins |url-status=live }}

| The mother of a 10-week-old baby who struggles to cope with motherhood due to her own mother dying. Valerie Pitman (Moyle) calls for social services to support Mira.

| rowspan="3" | 13 September

| {{nowrap|April Nerissa Hudson{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Sid Vere has a very BAD day! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-sid-vere-has-a-very-bad-day |access-date=15 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=15 September 2021 |archive-url=https://web.archive.org/web/20210915093041/https://www.whattowatch.com/spoilers/doctors-spoilers-sid-vere-has-a-very-bad-day |url-status=live }}}}

| A rapid responder who joins Sid Vere (Rice) on a shift.

| Cody Ryan

| A teenager whose mother dies in front of her after having waited too long for an ambulance to arrive.

| Jay Perry

| An emergency medical dispatcher who is frustrated with how long it takes for an ambulance to reach Iris Cotterill (Cody Ryan) and her dying mother.

| 14–23 September

| {{nowrap|Philip Martin Brown{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Can Emma Reid help clear Rob's name? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-can-emma-reid-help-clear-robs-name |access-date=15 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=15 September 2021 |archive-url=https://web.archive.org/web/20210915093038/https://www.whattowatch.com/spoilers/doctors-spoilers-can-emma-reid-help-clear-robs-name |url-status=live }}}}

| A homeless man who claims to have witnessed Harriet Shelton's (Stenson) involvement with what happened to Aaron Jeffries (Douglas).

| rowspan="3" | 14 September

| Craig Painting

| The husband of Piotr (Ellis Kirkhoven); the pair run a doctor's surgery together.

| Ellis Kirkhoven

| The husband of James (Craig Painting); the pair run a doctor's surgery together.

| Edward Aczel

| An inspector visiting James (Painting) and Piotr McAllister-Lipinski's (Kirkhoven) surgery to perform an inspection.

| rowspan="2" | 15 September

| Ashley Margolis{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Has Harriet Shelton been LYING? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-has-harriet-shelton-been-lying |access-date=15 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=15 September 2021 |archive-url=https://web.archive.org/web/20210915170029/https://www.whattowatch.com/spoilers/doctors-spoilers-has-harriet-shelton-been-lying |url-status=live }}

| A man who begins to suffer from cotard's syndrome following the death of his 11-year-old son, in which he was unable to save him.

| Kelly Clare

| The wife of Nick (Ashley Margolis) who learns that she is pregnant.

| 16–21 September

| Catherine Hannay{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: TV turn-off for Ruhma Carter! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-tv-turn-off-for-ruhma-carter |access-date=16 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=16 September 2021 |archive-url=https://web.archive.org/web/20210916171852/https://www.whattowatch.com/spoilers/doctors-spoilers-tv-turn-off-for-ruhma-carter |url-status=live }}

| A researcher on the fictional antique-hunting series Booty or Bust. She interviews Ruhma Carter (Patel) and Al Haskey (Midlane).

| rowspan="3" | 16 September

| Tina Harris

| The mother of Luke (Daniel Stiller) who informs him that due to her ancestry, he may have sickle cell disease.

| Chas Early

| The husband of Doreen (Tina Harris) who realises that his racist comments are inappropriate and have offended Doreen.

| Daniel Stiller

| A runner and the son of Doreen (Harris) who learns he may have sickle cell disease.

| rowspan="6" | 20–21 September

| Ryan Mal{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Emma Reid gets a SURPRISE patient! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-emma-reid-gets-a-surprise-patient |access-date=21 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=22 September 2021 |archive-url=https://web.archive.org/web/20210922013224/https://www.whattowatch.com/spoilers/doctors-spoilers-emma-reid-gets-a-surprise-patient |url-status=live }}

| A police officer who is informed by Emma Reid (Miles) and Valerie Pitman (Moyle) that Marvin Bulis (Philip Martin Brown) may have seen Harriet Shelton (Stenson) push Aaron Jefferies (Douglas) down a flight of stairs.

| Me'sha Bryan

| The presenter of Booty or Bust, an antique hunting series.

| Kim Wall

| An expert on Booty or Bust. Believing he is better than the job, he threatens to leave the series until he is informed that he cannot book another role. However, he is fired by the programme's director.

| Alison Egan

| An expert on Booty or Bust. She teams up with contestant Marji Webster (Doreene Blackstock). She later reveals to her husband Clive (Kim Wall) that she has been cheating on him with Marji for over a year. She is fired by the programme's director.

| David Hunter

| The director of Booty or Bust.

| Doreene Blackstock

| A contestant on Booty or Bust who reveals herself as Barbara Cookson's (Alison Egan) partner.

| 21 September

| Tim Hibberd{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Harriet Shelton becomes THREATENING… |url=https://www.whattowatch.com/spoilers/doctors-spoilers-harriet-shelton-becomes-threatening |access-date=21 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=21 September 2021 |archive-url=https://web.archive.org/web/20210921222510/https://www.whattowatch.com/spoilers/doctors-spoilers-harriet-shelton-becomes-threatening |url-status=live }}

| An auctioneer on Booty or Bust who gets promoted to an expert on the series after Clive (Wall) and Barbara Cookson (Egan) are fired.

| rowspan="3" | 22 September

| Matthew Khan{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Bear Sylvester helps homeless Hamil |url=https://www.whattowatch.com/spoilers/doctors-spoilers-bear-sylvester-helps-homeless-hamil |access-date=22 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=30 November 2021 |archive-url=https://web.archive.org/web/20211130191123/https://www.whattowatch.com/spoilers/doctors-spoilers-bear-sylvester-helps-homeless-hamil |url-status=live }}

| A gay Muslim who makes himself homeless due to feeling as though he will bring shame upon his family and local community. Donna Tompson (Tanya Vital) calls his sister Nadira (Safiyya Ingar) and helps him to repair his relationship with his family.

| Safiyya Ingar

| The brother of Nahil (Matthew Khan) who is accepting of his homosexuality.

| Tanya Vital

| A stand-up comedian who learns in her mid-40s that she is pregnant, despite paying for IVF for ten years with her ex.

| rowspan="3" | 23 September

| Zariah Bailey{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Valerie Pitman is questioned by the police |url=https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-is-questioned-by-the-police |access-date=27 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=27 September 2021 |archive-url=https://web.archive.org/web/20210927223337/https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-is-questioned-by-the-police |url-status=live }}

| Harpeet Khanna's (Gary Pillai) neighbour who has a physical altercation with him.

| Gary Pillai

| Alan Cooper's (Zariah Bailey) neighbour who has a physical altercation with him.

| {{nowrap|Rachael McGuinness}}

| Harpreet Khanna's (Pillai) girlfriend who attempts to blackmail Alan Cooper (Bailey) after seeing the two fighting.

| rowspan="3" | 27 September

| Rebecca Raybone{{cite news |last1=Lamacraft |first1=Tess |title='Doctors' spoilers: Karen Hollins is horrified when truth comes out |url=https://www.whattowatch.com/spoilers/doctors-spoilers-karen-hollins-is-horrified-when-truth-comes-out |access-date=27 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=27 September 2021 |archive-url=https://web.archive.org/web/20210927223327/https://www.whattowatch.com/spoilers/doctors-spoilers-karen-hollins-is-horrified-when-truth-comes-out |url-status=live }}

| The mother of recovering drug addict Jojo (Katherine Lea) who accuses her of stealing her dead father's watch.

| Katherine Lea

| A recovering drug addict who learns that her boyfriend, Kieran Coombes (Jack Lowe), has stolen her dead father's watch.

| Jack Lowe

| The boyfriend of Jojo Dougan (Lea) who steals her dead father's watch to fund their potential new home together.

| rowspan="3" | 28 September

| Madeleine Gray{{cite news |last1=Lamacraft |first1=Tess |title='Doctors' spoilers: Rob Hollins confronts Harriet about betrayal |url=https://www.whattowatch.com/spoilers/doctors-spoilers-rob-hollins-confronts-harriet-about-betrayal |access-date=27 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=28 September 2021 |archive-url=https://web.archive.org/web/20210928135123/https://www.whattowatch.com/spoilers/doctors-spoilers-rob-hollins-confronts-harriet-about-betrayal |url-status=live }}

| A social media influencer who exposes Ruby K (Alicia Lai) online due to Ruby advertising a dubious beauty clinic to her followers.

| Alicia Lai

| A popular social media influencer who gets exposed due to promoting a dubious beauty clinic that leaves Cora Thompson (Madelaine Gray) with health issues.

| Michael O'Reilly

| Ruby K's (Lai) ex-boyfriend who is used by Cora Thompson (Gray) to get in contact with her.

| {{nowrap|29 September–19 October}}

| Jim Findley{{cite news |last1=Lamacraft |first1=Tess |title='Doctors' spoilers: Daniel Granger has a moral dilemma |url=https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-has-a-moral-dilemma |access-date=29 September 2021 |work=What to Watch |publisher=(Future plc) |archive-date=28 September 2021 |archive-url=https://web.archive.org/web/20210928233845/https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-has-a-moral-dilemma |url-status=live }}

| The owner of a Caribbean café that rivals Makeda Sylvester's (Angela Wynter) café. The two form a short-lived romantic connection.

| {{nowrap|29 September–17 November}}

| Maya Soroya

| Rob Hollins' (Walker) counsellor who talks to him about his PTSD.

| rowspan="3" | 29 September

| Emily Aston

| Killian's (Harry Wyatt) mother who receives parcels of food from the council that Daniel Granger (Chambers) deems to be nutritionally unbalanced. She is encouraged to visit a food bank.

| Harry Wyatt

| Vikki's (Emily Aston) son who feels unwell due to not having a nutritional diet.

| Mark Carlisle

| The director of a company that provides food parcels to the local council. He offers Daniel Granger (Chambers) a job as his medical advisor, but Daniel informs him how unhealthy his food parcels are.

| rowspan="3" | 30 September

| Emma Stansfield{{cite news |last1=Lamacraft |first1=Tess |title='Doctors' spoilers: Bear Sylvester and Luca go undercover |url=https://www.whattowatch.com/spoilers/doctors-spoilers-bear-sylvester-and-luca-go-undercover |access-date=1 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=22 September 2021 |archive-url=https://web.archive.org/web/20210922102138/https://www.whattowatch.com/spoilers/doctors-spoilers-bear-sylvester-and-luca-go-undercover |url-status=live }}

| The mother of a 16-year-old who died after taking drugs at a party. She finds the family of the drug dealer, Amanda (Fiona Boylan) and Kellie Grant (Natalie Quarry), and informs them that their relative is responsible for her daughter's death.

| Fiona Boylan

| The wife of a man who is imprisoned for dealing drugs. Her daughter, Kellie (Quarry), learns that Amanda knew of his dealings and involved herself in his operation.

| Natalie Quarry

| The daughter of Amanda (Boylan) who learns that she was involved in a drug dealing operation led by her imprisoned father.

| rowspan="3" | 4 October

| Jake Graf{{cite news |last1=Lamacraft |first1=Tess |title='Doctors' spoilers: Daniel Granger is angry with Al |url=https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-is-angry-with-al |access-date=13 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=29 September 2021 |archive-url=https://web.archive.org/web/20210929163102/https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-is-angry-with-al |url-status=live }}

| A transgender man who is not accepted by his mother, Helena (Susan Kyd). He learns not to care what Helena thinks and later proposes to his girlfriend, April Lewin (Rachel Adedeji).

| Susan Kyd

| The mother of Olly (Jake Graf) who does not accept his gender transition and deadnames him.

| Rachel Adedeji

| The girlfriend of Olly Brockhurst (Graf) who sees Luca McIntyre (McLaren) about the worsened state of Olly's depression.

| rowspan="3" | 5 October

| Eleanor Kirby{{cite news |last1=Lamacraft |first1=Tess |title='Doctors' spoilers: Rhuma Carter helps a woman in labour |url=https://www.whattowatch.com/spoilers/doctors-spoilers-rhuma-carter-helps-a-woman-in-labour |access-date=13 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2021 |archive-url=https://web.archive.org/web/20211028133819/https://secure.adnxs.com/jpt?id=21147850&size=300x250&callback=headertag.GmsmHtb.adResponseCallback&callback_uid=wkOEkdRY&psa=0&promo_sizes=300x600&referrer=https%3A%2F%2Fwww.whattowatch.com%2Fspoilers%2Fdoctors-spoilers-rhuma-carter-helps-a-woman-in-labour&gdpr=0&gdpr_consent= |url-status=live }}

| Feargal Lumsden's (John Middleton) neighbour who tries to get him to sign his garden over to her until she learns of Feargal's dementia.

| John Middleton

| An elderly man with dementia who is put into a specialist care home by his daughter, Eileen (Tor Clark).

| Tor Clark

| Feargal's (Middleton) daughter who looks into putting him into a specialist care home due to her busy work schedule.

| rowspan="3" | 6 October

| Terence Booth{{cite news |last1=Lamacraft |first1=Tess |title='Doctors' spoilers: Rob Hollins opens up about his PTSD |url=https://www.whattowatch.com/spoilers/doctors-spoilers-rob-hollins-opens-up-about-his-ptsd |access-date=13 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2021 |archive-url=https://web.archive.org/web/20211028133844/https://secure.adnxs.com/jpt?id=21147851&size=300x250&callback=headertag.GmsmHtb.adResponseCallback&callback_uid=wrrO9Qen&psa=0&promo_sizes=300x600&referrer=https%3A%2F%2Fwww.whattowatch.com%2Fspoilers%2Fdoctors-spoilers-rob-hollins-opens-up-about-his-ptsd&gdpr=0&gdpr_consent= |url-status=live }}

| A man who pretends to be suffering from dementia to garner company from Gemma Wilks (Charlotte Workman) and Ann Harris (Hayley Considine).

| Charlotte Workman

| A former carer who unofficially cares for Don Harris (Terence Booth).

| Hayley Considine

| The daughter of Don Harris (Booth) who apologises for rarely visiting him.

| rowspan="2" | 7 October

| Bessie Coates{{cite news |last1=Lamacraft |first1=Tess |title='Doctors' spoilers: Is Karen Hollins' marriage over? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-is-karen-hollins-marriage-over |access-date=13 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2021 |archive-url=https://web.archive.org/web/20211028133839/https://secure.adnxs.com/jpt?id=21147846&size=728x90&callback=headertag.GmsmHtb.adResponseCallback&callback_uid=22F39ede&psa=0&promo_sizes=970x250%2C970x90&referrer=https%3A%2F%2Fwww.whattowatch.com%2Fspoilers%2Fdoctors-spoilers-is-karen-hollins-marriage-over&gdpr=0&gdpr_consent= |url-status=live }}

| A university student recovering from cancer. After her throat becomes itchy, she becomes paranoid that her cancer has returned and becomes anxious.

| Georgia Bruce

| Cassie Clarke's (Bessie Coates) flatmate who worries about her mental health.

| rowspan="3" | 11 October

| Nick Judge{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: WHERE is Rob Hollins? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-where-is-rob-hollins |access-date=13 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2021 |archive-url=https://web.archive.org/web/20211028133821/https://secure.adnxs.com/jpt?id=21147851&size=300x250&callback=headertag.GmsmHtb.adResponseCallback&callback_uid=3EXMY0O2&psa=0&promo_sizes=300x600&referrer=https%3A%2F%2Fwww.whattowatch.com%2Fspoilers%2Fdoctors-spoilers-where-is-rob-hollins&gdpr=0&gdpr_consent= |url-status=live }}

| A criminal who robs a bottle of alcohol from a shop.

| James S Barnes

| A police officer who gives Johnny Cartwright (Nick Judge) an alibi.

| Rebecca Yeo

| A police constable who asks Emma Reid (Miles) about applying for Harriet Shelton's (Stenson) former job.

| rowspan="3" | 12 October

| Fiona Sagar{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Al Haskey discovers WHO Starbuck is! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-al-haskey-discovers-who-starbuck-is |access-date=13 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2021 |archive-url=https://web.archive.org/web/20211028133849/https://secure.adnxs.com/jpt?id=21147851&size=300x250&callback=headertag.GmsmHtb.adResponseCallback&callback_uid=3XSQvd2Q&psa=0&promo_sizes=300x600&referrer=https%3A%2F%2Fwww.whattowatch.com%2Fspoilers%2Fdoctors-spoilers-al-haskey-discovers-who-starbuck-is&gdpr=0&gdpr_consent= |url-status=live }}

| A pregnant patient of Ruhma Carter's (Patel) who hires an escort to act as her birthing partner.

| {{nowrap|Gina Fillingham}}

| A pregnant patient of Ruhma Carter's (Patel) who brings a hamster into her midwifery appointment as an emotional support animal.

| Adam Gillian

| An escort that Kate Lodge (Fiona Sagar) hires to be her birthing partner.

| 13–28 October

| Caroline Head

| A woman that Al Haskey (Midlane) believes he is talking to online. He later learns that he has been talking to Keith 'Starbuck' Dursley (Rufus Hound), an employee of Casey's.

| rowspan="4" | 13 October

| Cal Freestone{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Will Zara Carmichael help Karen in CRISIS? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-zara-carmichael-help-karen-in-crisis |access-date=13 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2021 |archive-url=https://web.archive.org/web/20211028133850/https://secure.adnxs.com/jpt?id=21147851&size=300x250&callback=headertag.GmsmHtb.adResponseCallback&callback_uid=GfytJAl9&psa=0&promo_sizes=300x600&referrer=https%3A%2F%2Fwww.whattowatch.com%2Fspoilers%2Fdoctors-spoilers-will-zara-carmichael-help-karen-in-crisis&gdpr=0&gdpr_consent= |url-status=live }}

| A police officer that handles Morgan Scott's (Cora Kirk) case of sexual assault.

| Cora Kirk

| A woman who is sexually assaulted by Jeremy Hyde (Alistair Kirton) after meeting him for coffee.

| Craig Conway

| The father of Morgan (Kirk) who worries about her welfare.

| Alistair Kirton

| A man who sexually assaults Morgan Scott (Kirk) by holding her at knifepoint.

| rowspan="2" | 14 October

| Francis Johnson{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Can Bear Sylvester change his mum's mind? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-can-bear-sylvester-change-his-mums-mind |access-date=15 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=15 October 2021 |archive-url=https://web.archive.org/web/20211015194709/https://www.whattowatch.com/spoilers/doctors-spoilers-can-bear-sylvester-change-his-mums-mind |url-status=live }}

| The partner of Callum Leanord (David Bromley) who is confused when Callum shuts himself away. Callum later explains that he is trying to aid Aaron's feelings for when he dies, but Aaron explains that he wants to enjoy their lives together.

| David Bromley

| The partner of Aaron Brett (Francis Johnson). Callum fears that he is dying and in response, shuts himself away from Aaron so that he is not as affected when he dies.

| rowspan="2" | 18 October

| Pena Ilyambo{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: WHO does Jimmi Clay lose his temper with? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-who-does-jimmi-clay-lose-his-temper-with |access-date=18 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=18 October 2021 |archive-url=https://web.archive.org/web/20211018193419/https://www.whattowatch.com/spoilers/doctors-spoilers-who-does-jimmi-clay-lose-his-temper-with |url-status=live }}

| A trainee for the Royal Air Force who learns that she may have diabetes.

| {{nowrap|Xsara-Sheneille Pryce}}

| A friend of Kirsten Murray's (Pena Ilyambo) who was in the Royal Air Force.

| rowspan="3" | 19 October

| Ethan Moorhouse{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Can Karen Hollins convince Rob to return? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-can-karen-hollins-convince-rob-to-return |access-date=19 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=19 October 2021 |archive-url=https://web.archive.org/web/20211019194654/https://www.whattowatch.com/spoilers/doctors-spoilers-can-karen-hollins-convince-rob-to-return |url-status=live }}

| A former soldier who begins working at St. Phils Hospital as a cleaner after an injury in Afghanistan.

| Joao Faulkner

| The son of Trish (Savannah Stevens) who struggles with her having another child.

| Savannah Stevens

| A pregnant patient of Ruhma Carter's (Patel).

| rowspan="3" | 20 October

| Theo Johnson{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Sid Vere is MENACED by a teenage gang... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-sid-vere-is-menaced-by-a-teenage-gang |access-date=20 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2021 |archive-url=https://web.archive.org/web/20211028133902/https://www.whattowatch.com/media/css/whattowatch.min.css |url-status=live }}

| rowspan="3" | Three teenagers who hijack Sid Vere's (Rice) ambulance which has blood for a blood transplant inside. They take the blood and ask for money in return for it back, but run away when he is unable to pay.

| Emily Belcher

| Dumo Mkweli

| 21 October

| Sean Knopp{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Valerie Pitman has a REVELATION! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-has-a-revelation |access-date=21 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2021 |archive-url=https://web.archive.org/web/20211028133851/https://secure.adnxs.com/jpt?id=21147846&size=728x90&callback=headertag.GmsmHtb.adResponseCallback&callback_uid=WRcRvvS2&psa=0&promo_sizes=970x250%2C970x90&referrer=https%3A%2F%2Fwww.whattowatch.com%2Fspoilers%2Fdoctors-spoilers-valerie-pitman-has-a-revelation&gdpr=0&gdpr_consent= |url-status=live }}

| A man with post partum psychosis. David takes his child away from his mother; she reports him as missing and the police find them.

| rowspan="2" | 25 October

| Halema Hussain{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Will Al Haskey make peace with Jimmi Clay? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-al-haskey-make-peace-with-jimmi-clay |access-date=21 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2021 |archive-url=https://web.archive.org/web/20211028133821/https://secure.adnxs.com/jpt?id=21147851&size=300x250&callback=headertag.GmsmHtb.adResponseCallback&callback_uid=SQKGd5n9&psa=0&promo_sizes=300x600&referrer=https%3A%2F%2Fwww.whattowatch.com%2Fspoilers%2Fdoctors-spoilers-will-al-haskey-make-peace-with-jimmi-clay&gdpr=0&gdpr_consent= |url-status=live }}

| A girl that Shak Hanif (Sunjay Midda) attempts to impress.

| Danish Latif

| An ex-boyfriend of Amira Mirza's (Halema Hussain) that reveals to Shak Hanif (Midda) that he bankrupted himself by spending £5000 on Amira to impress her.

| rowspan="2" | 26 October

| Paul Copley{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Karen Hollins has a BAD day! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-karen-hollins-has-a-bad-day |access-date=26 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=26 October 2021 |archive-url=https://web.archive.org/web/20211026230129/https://www.whattowatch.com/spoilers/doctors-spoilers-karen-hollins-has-a-bad-day |url-status=live }}

| A parking enforcement officer who fraudulently gives people at the Campus Surgery fake tickets that are paid to his own bank account.

| Andria Doherty

| The wife of Ernie (Paul Copley).

| rowspan="3" | 27 October

| Jacqueline Boatswain{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Ex-Hollyoaks star Jacqueline Boatswain guests |url=https://www.whattowatch.com/spoilers/doctors-spoilers-ex-hollyoaks-star-jacqueline-boatswain-guests |access-date=27 October 2021 |work=What to Watch |publisher=(Future plc) |archive-date=28 October 2021 |archive-url=https://web.archive.org/web/20211028133852/https://secure.adnxs.com/jpt?id=21147846&size=728x90&callback=headertag.GmsmHtb.adResponseCallback&callback_uid=8JAiYrUp&psa=0&promo_sizes=970x250%2C970x90&referrer=https%3A%2F%2Fwww.whattowatch.com%2Fspoilers%2Fdoctors-spoilers-ex-hollyoaks-star-jacqueline-boatswain-guests&gdpr=0&gdpr_consent= |url-status=live }}

| The mother of Rachel (Ruby Crepin-Glyne) and Bex (Shanice Archer). Her husband died of COVID-19 passed on to him by Bex.

| {{nowrap|Ruby Crepin-Glyne}}

| A university student who initially blames herself for the death of her father. She later learns that her sister Bex (Archer) gave him COVID-19.

| Shanice Archer

| A woman who learns that she passed COVID-19 onto her father.

| {{nowrap|28 October–15 November}}

| Rufus Hound{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Al Haskey meets Starbuck! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-al-haskey-meets-starbuck |access-date=28 October 2021 |work=What to Watch |publisher=(Future plc) }}

| A man who Al Haskey (Midlane) talks to online. Al believes that Keith is a woman and is shocked to learn on their date that he is a man; the pair become friends instead.

| {{nowrap|28 October–4 November}}

| Paddy Navin

| The head of the committee for the Letherbridge Environmental Day.

| rowspan="4" | 1 November

| Eve Shotton{{cite episode|title=The Unkindest Cut|url=https://www.bbc.co.uk/programmes/m00116p3|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|airdate=1 November 2021|access-date=16 November 2021|archive-date=17 November 2021|archive-url=https://web.archive.org/web/20211117205057/https://www.bbc.co.uk/programmes/m00116p3|url-status=live}}

| A woman who believes that having children is damaging to the environment; she later becomes pregnant but decides to keep the baby.

| Daniel Boyd

| A man who gets a vasectomy due to believing that having children is damaging to the environment.

| Helen Pearson

| The mother of Jeremy and Jenny who is elated to learn that she will be a grandmother.

| Jarreau Antoine

| A man who unsuccessfully auditions for Daniel Granger (Chambers) and Brenda Malachi-Jones (Paddy Navin) to be the lead actor of their environmental campaign.

| rowspan="3" | 2 November

| Timothy Harker{{cite episode|title=Knocking Dollies|url=https://www.bbc.co.uk/programmes/m00116v7|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|airdate=2 November 2021|access-date=16 November 2021|archive-date=30 November 2021|archive-url=https://web.archive.org/web/20211130191152/https://www.bbc.co.uk/programmes/m00116v7|url-status=live}}

| A non-binary patient of the Mill that explains to Karen Hollins (Pearson) that they have difficulty going out of the house.

| Royce Cronin

| A former student of Charly Stafford (Timothy Harker).

| Billy Rilot

| A teenager who gets tutoring from Charly Stafford (Harker).

| rowspan="2" | 3 November

| Sydney Stevens{{cite episode|title=Smotherhood|url=https://www.bbc.co.uk/programmes/m00117gd|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|airdate=3 November 2021|access-date=16 November 2021|archive-date=17 November 2021|archive-url=https://web.archive.org/web/20211117205104/https://www.bbc.co.uk/programmes/m00117gd|url-status=live}}

| A girl who accidentally overdoses on her medication; Al Haskey (Midlane) informs her that her reaction is due to having grapefruit juice with her antidepressant medication.

| Diana Weston

| The concerned mother of Ellie (Sydney Stevens).

| rowspan="3" | 4 November

| Mollie Holder{{cite episode|title=Hero|url=https://www.bbc.co.uk/programmes/m00116mm|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|airdate=4 November 2021|access-date=16 November 2021|archive-date=30 November 2021|archive-url=https://web.archive.org/web/20211130191152/https://www.bbc.co.uk/programmes/m00116mm|url-status=live}}

| rowspan="2" | Two students who reprimand Todd Jarrett (Josh Tedeku) for illegal dumping.

| Daniel Blacker

| Josh Tedeku

| A painter who attempts to illegally dump old paint cans in a river.

| rowspan="2" | 8 November

| Tom McCall{{cite episode|title=Close Up|url=https://www.bbc.co.uk/programmes/m0011fgb|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|airdate=8 November 2021|access-date=16 November 2021|archive-date=17 November 2021|archive-url=https://web.archive.org/web/20211117205101/https://www.bbc.co.uk/programmes/m0011fgb|url-status=live}}

| Sid Vere's (Rice) patient with deteriorating asthma. He finds that Bernie's worsening asthma is due to the flowers in his house.

| Sophie Robinson

| Bernie's (Tom McCall) wife.

| 9–18 November

| Kirsten Foster{{cite episode|title=Signs of Life|url=https://www.bbc.co.uk/programmes/m0011gc5|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|airdate=9 November 2021|access-date=16 November 2021|archive-date=17 November 2021|archive-url=https://web.archive.org/web/20211117205102/https://www.bbc.co.uk/programmes/m0011gc5|url-status=live}}

| The doctor overseeing Makeda Sylvester (Wynter) at St. Phils Hospital.

| rowspan="3" | 10 November

| James Cartmell{{cite episode|title=The Burden of Debt|url=https://www.bbc.co.uk/programmes/m0011fqt|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|airdate=10 November 2021|access-date=16 November 2021|archive-date=11 November 2021|archive-url=https://web.archive.org/web/20211111000920/https://www.bbc.co.uk/programmes/m0011fqt|url-status=live}}

| A teenager who receives a heart transplant from Richard Waters' (Christopher Larkin) dead son.

| Max Dowler

| Jack's (James Cartmell) father who is distraught to learn he has stopped taking the medication prescribed for his heart transplant.

| Christopher Larkin

| The father of a teenager who dies; his heart is given to Jack Turner (Cartmell).

| rowspan="2" | 11 November

| Rachel Flynn{{cite episode|title=Chances Are|url=https://www.bbc.co.uk/programmes/m0011fxx|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|airdate=11 November 2021|access-date=16 November 2021|archive-date=17 November 2021|archive-url=https://web.archive.org/web/20211117205058/https://www.bbc.co.uk/programmes/m0011fxx|url-status=live}}

| A woman in an abusive relationship with Ross Jenkins (Chris Hoskins). After ending their relationship and a failed attempt to escape, Ross chases her upstairs and murders her.

| Chris Hoskins

| An abuser who murders his ex-girlfriend Lou Myers (Rachel Flynn).

| rowspan="3" | 15 November

| Marlene Sidaway{{cite episode|title=Locked In|url=https://www.bbc.co.uk/programmes/m0011n7f|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|airdate=15 November 2021|access-date=16 November 2021|archive-date=30 November 2021|archive-url=https://web.archive.org/web/20211130191126/https://www.bbc.co.uk/programmes/m0011n7f|url-status=live}}

| The grandmother of Kai (Kyle Rowe) who uses the cellar in her house to imprison Nataliya Kosenko (Maja Laskowska).

| Kyle Rowe

| A man who imprisons Nataliya Kosenko (Laskowska) in his grandmother's cellar; he invites men over each night to pay to have sex with her until she escapes and his grandmother informs the police.

| Maja Laskowska

| A Ukrainian woman who was trafficked to England by Kai Southcliffe (Rowe); he locks her in a cellar and has men pay him to have sex with her.

| 16–18 November

| Graham Hoadly{{cite episode|title=Rude Awakenings|url=https://www.bbc.co.uk/programmes/m0011nj2|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|airdate=16 November 2021|access-date=16 November 2021|archive-date=16 November 2021|archive-url=https://web.archive.org/web/20211116073457/https://www.bbc.co.uk/programmes/m0011nj2|url-status=live}}

| The head of the endoscopy unit at St. Phils Hospital. He assumes Bear Sylvester (Lee) is being aggressive due to him confronting Cathy Jenkins (Laura Bayston) on her racism and asks him to leave.

| 16 November 2021,
{{nowrap|7–15 June 2022}}

| Laura Bayston

| A nurse at St. Phils Hospital who treats Makeda Sylvester (Wynter) poorly due to her being black. Her treatment discourages Makeda from receiving her endoscopy. Months later, she begins working at the Mill temporarily. When Bear learns of her employment, he informs the staff that Cathy is a racist, and they turn on her. Ruhma Carter (Patel) tries to show Cathy kindness, but after Ruhma informs her that she is not on her side, Cathy makes a racist comment and leaves.

| 16 November

| Christopher Jaciow

| A security guard at St. Phils Hospital. He assumes that Bear Sylvester (Lee) is loitering in the hallways despite him explaining that he is there for his mother; he later removes him due to believing he is acting aggressively.

| rowspan="2" | 17 November

| Stuart Quigley{{cite episode|title=The Imitation Game|url=https://www.bbc.co.uk/programmes/m0011nr0|series=Doctors|series-link=Doctors (2000 TV series)|network=BBC|station=BBC One|airdate=17 November 2021|access-date=16 November 2021|archive-date=15 November 2021|archive-url=https://web.archive.org/web/20211115151434/https://www.bbc.co.uk/programmes/m0011nr0|url-status=live}}

| A university student with symptoms of schizophrenia. In an attempt to get prescription drugs, his friend, Johan Marsh (Tevye Matheson), pretends to be him at the surgery.

| Tevye Matheson

| Sam Bailey's (Stuart Quigley) friend who pretends to be him in a consultation with Zara Carmichael (Walsh) to get prescription drugs.

| rowspan="3" | 18 November

| Victoria Moseley{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Will Bear Sylvester DROP his complaint? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-will-bear-sylvester-drop-his-complaint |access-date=19 November 2021 |work=What to Watch |publisher=(Future plc) |archive-date=19 November 2021 |archive-url=https://web.archive.org/web/20211119170206/https://www.whattowatch.com/spoilers/doctors-spoilers-will-bear-sylvester-drop-his-complaint |url-status=live }}

| A gambling addict. Her husband, Anish (David Kukadia), discovers that she has been gambling again and persuades her to get help from the Mill.

| Duaa Karim

| The teenage daughter of Beth (Victoria Moseley) and Anish (Kukadia) who is unaware of her mother's gambling addiction.

| David Kukadia

| The husband of Beth (Moseley), a gambling addict. He discovers that she has been gambling again and persuades her to seek help from the Mill.

| rowspan="3" | 22 November

| Trudie Goodwin{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Trudie Goodwin guest stars |url=https://www.whattowatch.com/spoilers/doctors-spoilers-trudie-goodwin-guest-stars |access-date=22 November 2021 |work=What to Watch |publisher=(Future plc) |archive-date=22 November 2021 |archive-url=https://web.archive.org/web/20211122220810/https://www.whattowatch.com/spoilers/doctors-spoilers-trudie-goodwin-guest-stars |url-status=live }}

| The mother of Phil (Louis Tamone) who discovers that he is cheating on his girlfriend, Simone Paoli (Angelique Joan), who cares for Meg.

| Angelique Joan

| The girlfriend of Phil Clarke (Tamone) who cares for his mother, Meg (Trudie Goodwin).

| Louis Tamone

| The son of Meg (Goodwin). Meg discovers that he has been cheating on his girlfriend, Simone Paoli (Joan), and exposes him.

| rowspan="3" | 23 November

| Mark Oosterveen{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Rob Hollins is back on the beat... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-rob-hollins-is-back-on-the-beat |access-date=25 November 2021 |work=What to Watch |publisher=(Future plc) |archive-date=25 November 2021 |archive-url=https://web.archive.org/web/20211125142630/https://www.whattowatch.com/spoilers/doctors-spoilers-rob-hollins-is-back-on-the-beat |url-status=live }}

| An administrator at St. Phils Hospital who responds to Bear Sylvester's (Lee) experiences with racism in the hospital. He suggests that Bear leads his forthcoming diversity initiative, but he refuses due to believing that as the victim of racism, he should not have to fix the hospital's racism issues.

| Andrew Readman

| A prison inmate who claims to have amnesia. Due to his experience with Karen Hollins' (Pearson) amnesia, Rob Hollins (Walker) recognises that Thomas does not have amnesia and is instead a missing person.

| Helen Aluko

| A police constable at Letherbridge Police Station who does not initially get on with Rob Hollins (Walker).

| rowspan="3" | 24 November

| Gabrielle Lloyd{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: A clinically vulnerable patient needs help |url=https://www.whattowatch.com/spoilers/doctors-spoilers-a-clinically-vulnerable-patient-needs-help |access-date=25 November 2021 |work=What to Watch |publisher=(Future plc) |archive-date=25 November 2021 |archive-url=https://web.archive.org/web/20211125142631/https://www.whattowatch.com/spoilers/doctors-spoilers-a-clinically-vulnerable-patient-needs-help |url-status=live }}

| A woman who, during the COVID-19 pandemic, is surprised to is forced to shield from her son, Dennis (Robert Ewens), who has a learning disability, due to not being allowed to visit his care home. He later dies alone, which she blames herself for.

| Robert Ewens

| The son of Doris (Gabrielle Lloyd) who dies alone during the COVID-19 pandemic.

| Nigel Betts

| The partner of Doris James (Lloyd), who he meets during the COVID-19 pandemic. The pair complete word searches together over the phone until they are able to safely meet.

| {{nowrap|25 November–2 December}}

| Graham Seed{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Sid Vere goes SKYDIVING! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-sid-vere-goes-skydiving |access-date=25 November 2021 |work=What to Watch |publisher=(Future plc) |archive-date=25 November 2021 |archive-url=https://web.archive.org/web/20211125142843/https://www.whattowatch.com/spoilers/doctors-spoilers-sid-vere-goes-skydiving |url-status=live }}

| An actor that Maggie Lynch (Alison Belbin) introduces to Karen Hollins (Pearson) to act as her boyfriend to make Rob Hollins (Walker) jealous. He forms real feelings for Karen and admits his admiration for her, but she affirms that she does not like him.

| rowspan="4" | 25 November

| Jonathan Tafler

| rowspan="3" | Method actors who pretend that Stefan has died and conjure a murder mystery. Luca MacIntyre (McLaren) is not informed that the investigation is fictional and is horrified to be accused of murdering Stefan, his patient.

| Sophie Duval

| Adrian Richards

| Adrian Christopher

| A sky diving instructor who assists Laurence Richards (Rishard Beckett) and Sid Vere (Rice) with their sky dive.

| {{nowrap|29 November 2021,}}
{{nowrap|14 June 2022,}}
{{nowrap|11 March 2024}}

| Danny Szam{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Emma Reid in MURDER investigation! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-emma-reid-in-murder-investigation |access-date=29 November 2021 |work=What to Watch |publisher=(Future plc) |archive-date=30 November 2021 |archive-url=https://web.archive.org/web/20211130191125/https://www.whattowatch.com/spoilers/doctors-spoilers-emma-reid-in-murder-investigation |url-status=live }}

| A detective sergeant who questions Chelsie Parks (LJ Johnson) and Rose Griffin (Fabienne Piolini-Castle) on a murder they have committed together.

| rowspan="2" | 29 November

| LJ Johnson

| A woman who is coerced into murdering a man with her best friend, Rose Griffin (Piolini-Castle). Despite Rose placing the blame on her, Chelsie does not expose Rose.

| {{nowrap|Fabienne Piolini-Castle}}

| A woman who coerces her best friend, Chelsie Parks (Johnson), into murdering a man. She then places the blame on Chelsie when questioned by Mike Kinsella (Danny Szam).

| {{nowrap|30 November, 16 December}}

| Jack O'Connor{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Valerie Pitman goes wedding dress shopping! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-goes-wedding-dress-shopping |access-date=30 November 2021 |work=What to Watch |publisher=(Future plc) |archive-date=30 November 2021 |archive-url=https://web.archive.org/web/20211130191125/https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-goes-wedding-dress-shopping |url-status=live }}

| A patient of Luca McIntyre's (McLaren) that sees him after contracting gonorrhoea after having sex with a man. He worries about getting HIV/AIDS from the encounter, so to assure him that people with HIV can lead healthy and full lives, Luca explains that he is HIV-positive and healthy, which Conor is disgusted by. He posts about Luca's HIV online, which is met with disgust from patients of the Mill.

| rowspan="3" | 30 November

| Lin Blakley

| An activist who is convinced by her partner, Ruby Maynard (Sandy Walsh), to move her protesting online due to continuously risking her health.

| Sandy Walsh

| The partner of activist Alice Eliot (Lin Blakley) who convinces her to move her protesting online due to risking her health.

| {{nowrap|Jake Kenny-Byrne}}

| The grandson of Alice (Blakley) who joins her on protests.

| rowspan="3" | 1 December

| Jack Wilkinson{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: SHOCK revelation about Luca McIntyre... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-shock-revelation-about-luca-mcintyre |access-date=8 December 2021 |work=What to Watch |publisher=(Future plc) |archive-date=7 December 2021 |archive-url=https://web.archive.org/web/20211207182832/https://www.whattowatch.com/spoilers/doctors-spoilers-shock-revelation-about-luca-mcintyre |url-status=live }}

| A man who becomes worried about his pregnant girlfriend, Jenny Davenport (Anna Elisabeth Mary Wright), when she searches through their belongings erratically. She later reveals that she meant to propose to him but that she has lost the ring.

| {{nowrap|Anna Elisabeth Mary Wright}}

| A pregnant patient of Ruhma Carter's (Patel) who accuses restaurant owner Alfredo Cavalli (Joseph Long) of stealing her engagement ring.

| Joseph Long

| A restaurant owner who is accused of stealing Jenny Davenport's (Wright) engagement ring.

| rowspan="3" | 2 December

| Debra Baker{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Surgery SCANDAL for Daniel Granger... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-surgery-scandal-for-daniel-granger |access-date=8 December 2021 |work=What to Watch |publisher=(Future plc) |archive-date=7 December 2021 |archive-url=https://web.archive.org/web/20211207193636/https://www.whattowatch.com/spoilers/doctors-spoilers-surgery-scandal-for-daniel-granger |url-status=live }}

| A nervous patient of Sid Vere's (Rice) who refuses to be treated while Luca McIntyre (McLaren) is at the Mill due to his HIV+ status. Her colleague, Joni Tierney (Emma Bispham), explains that his HIV cannot be transmitted to her and persuades her to be treated.

| Emma Bispham

| Mo Pemberton's (Debra Baker) colleague who explains that Luca McIntyre's (McLaren) HIV cannot be transmitted to her.

| Sean McKenzie

| The boss of Mo Pemberton (Baker) and Joni Tierney (Bispham).

| {{nowrap|6–9 December}}

| Dean Williamson

| A man who protests at the Mill due to believing that Luca McIntyre's (McLaren) HIV is transmittable to patients. Al Haskey (Midlane) informs him that this is impossible and forces Tony to leave.

| 6 December

| Dan Hagley

| A delivery driver who gives Chelle Henry (Kevwe Emefe) a free dining table.

| rowspan="3" | 7 December

| Princess Khumalo{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Daniel Granger exposes a loan shark! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-exposes-a-loan-shark |access-date=8 December 2021 |work=What to Watch |publisher=(Future plc) |archive-date=7 December 2021 |archive-url=https://web.archive.org/web/20211207193844/https://www.whattowatch.com/spoilers/doctors-spoilers-daniel-granger-exposes-a-loan-shark |url-status=live }}

| A medical student at Letherbridge University who is scammed into taking a £12,000 unsecured loan by Fiona Edusei (Denise Laniyan).

| Denise Laniyan

| An international criminal who poses as a university student to scam students into investing in her business.

| Laura Cairns

| A student services staff member at Letherbridge University who plans to change the pastoral care procedures due to students having money struggles.

| {{nowrap|8–13 December}}

| Jessica Temple{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Luca McIntyre films a video message... |url=https://www.whattowatch.com/spoilers/doctors-spoilers-luca-mcintyre-films-a-video-message |access-date=8 December 2021 |work=What to Watch |publisher=(Future plc) |archive-date=12 December 2021 |archive-url=https://web.archive.org/web/20211212214659/https://www.whattowatch.com/spoilers/doctors-spoilers-luca-mcintyre-films-a-video-message |url-status=live }}

| A patient of Ruhma Carter's (Patel).

| rowspan="2" | 8 December

| Jilly Bond

| The manipulative mother of Chloe (Imogen Wilde) who gaslights her into thinking she is a bad daughter. Sid Vere (Rice) notices and calls her behaviour out.

| Imogen Wilde

| The daughter of Nina (Jilly Bond) who, after Sid Vere (Rice) points it out, realises that her mother has been gaslighting her for as long as she can remember.

| rowspan="3" | 9 December

| Ian Reddington{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: The Mill is VANDALISED! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-the-mill-is-vandalised |access-date=9 December 2021 |work=What to Watch |publisher=(Future plc) |archive-date=12 December 2021 |archive-url=https://web.archive.org/web/20211212214702/https://www.whattowatch.com/spoilers/doctors-spoilers-the-mill-is-vandalised |url-status=live }}

| A ventriloquist who breaks his wrist after punching a wall. He worries about how he will perform his ventriloquism act due to his tour providing the majority of his revenue.

| Tyler Reddington

| Frankie's (Ian Reddington) son who is tired of his father's ventriloquism act due to him spending the majority of his time on it.

| {{nowrap|Daniel Reid-Walters}}

| Imogen Hollins' (Charlie Clemmow) ex-boyfriend from school who she arranges to meet with. He confides in Imogen about the breakdown of his marriage to his wife and how he is being bullied at work.

| 13 December

| Colette Zacca{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Rob and Karen Hollins investigate Imogen! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-rob-and-karen-hollins-investigate-imogen |access-date=14 December 2021 |work=What to Watch |publisher=(Future plc) |archive-date=16 December 2021 |archive-url=https://web.archive.org/web/20211216203817/https://www.whattowatch.com/spoilers/doctors-spoilers-rob-and-karen-hollins-investigate-imogen |url-status=live }}

| Bear Sylvester's (Lee) aunt who learns that her mobile home is set to be towed due to damages on the vehicle that she cannot afford. Bear offers to pay for the fixes but she refuses to be in debt. Bear finds a stash of lottery tickets that Dorothy has collected and checks the numbers to find that she has won and can afford the repairs.

| 14 December

| Jay Oliver Yip{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Valerie Pitman wants a STRIPPER! |url=https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-wants-a-stripper |access-date=14 December 2021 |work=What to Watch |publisher=(Future plc) |archive-date=16 December 2021 |archive-url=https://web.archive.org/web/20211216204459/https://www.whattowatch.com/spoilers/doctors-spoilers-valerie-pitman-wants-a-stripper |url-status=live }}

| A man with mental health issues who visits his children on the custody day. His wife phones the police and accuses him of breaking and entering.

| rowspan="4" | 15 December

| Chloe Proctor

| Doug Abbott's (Shaun Prendergast) daughter who refuses to invite him to the family Christmas celebrations due his alcoholism.

| Shaun Prendergast

| A recovering alcoholic who has recently had a major bowel cancer surgery. His friend, Alan Ellis (Rowe David McClelland), encourages him to drink.

| {{nowrap|Rowe David McClelland

| Doug Abbott's (Prendergast) drinking friend.

| Stephen Leask{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Wedding day DISASTER for Valerie Pitman? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-wedding-day-disaster-for-valerie-pitman |access-date=14 December 2021 |work=What to Watch |publisher=(Future plc) |archive-date=16 December 2021 |archive-url=https://web.archive.org/web/20211216204458/https://www.whattowatch.com/spoilers/doctors-spoilers-wedding-day-disaster-for-valerie-pitman |url-status=live }}

| An overly keen mattress salesman who encourages Karen (Pearson) and Rob Hollins (Walker) to buy two mattresses from his shop.

| rowspan="3" | 16 December

| Nick Oliver{{cite news |last1=Timblick |first1=Simon |title='Doctors' spoilers: Does Valerie Pitman FINALLY get married? |url=https://www.whattowatch.com/spoilers/doctors-spoilers-does-valerie-pitman-finally-get-married |access-date=14 December 2021 |work=What to Watch |publisher=(Future plc) |archive-date=16 December 2021 |archive-url=https://web.archive.org/web/20211216204500/https://www.whattowatch.com/spoilers/doctors-spoilers-does-valerie-pitman-finally-get-married |url-status=live }}

| A security guard who Daniel Granger (Chambers) finds washing in the campus surgery toilets. He notifies Derek Selby (Patrick Brennan), the acting head of security, but then finds out that Chris is homeless and has been sleeping in the toilets.

| Patrick Brennan

| The acting head of security for Letherbridge University.

| Evie Killip

| Chris' (Oliver) pregnant wife.