| class="wikitable sortable"
!Chapter
!Charter date and range
!Institution
!Location
!Status
!References |
| Alpha
|1921
|A.T. Still University
|Kirksville, Missouri
|Active
|[Robson, John, ed. (1963). Baird's Manual of American College Fraternities (17th ed.). Menasha, Wisconsin: The Collegiate Press, George Banta Company, Inc., p. 554.]{{Efn|Chapter formed at the Kirksville College of Osteopathic Medicine, now A.T. Still University}} |
| Beta
|1925
|Des Moines University
|Des Moines, Iowa
|Active
| |
| Gamma (First)
|1930
|Los Angeles College of Osteopathic Physicians and Surgeons
|Irvine, California
|Inactive, Reassigned
| |
| rowspan="2" |Delta
|1932
|Kansas City University
|Kansas City, Missouri
| rowspan="2" |Active
| rowspan="2" | |
| May 2018
|Kansas City University, Joplin
|Joplin, Missouri |
| Epsilon
|1939
|Chicago College of Osteopathic Medicine
|Downers Grove, Illinois
|Active
|[{{Cite web |title=Sigma Sigma Phi |url=https://mwupulse.campuslabs.com/engage/Account/Login?ReturnUrl=%2Fengage%2Forganization%2Fssp |access-date=2025-05-15 |website=Midwestern University}}] |
| rowspan="3" |Zeta
|19xx ?–19xx ?; March 1997
|Philadelphia College of Osteopathic Medicine
|Philadelphia, Pennsylvania
| rowspan="3" |Active
| rowspan="3" | |
| |Philadelphia College of Osteopathic Medicine, Moultrie Campus
|Moultrie, Georgia |
| |Philadelphia College of Osteopathic Medicine, Suwanee Campus
|Suwanee, Georgia |
| Eta
|
|University of North Texas Health Science Center
|Fort Worth, Texas
|Active
| |
| Theta
|
|Oklahoma State University Center for Health Sciences College of Osteopathic Medicine
|Tulsa, Oklahoma
|Active
| |
| Iota
|
|Michigan State University College of Osteopathic Medicine
|East Lansing, Michigan
|Active
| |
| Kappa
|
|University of New England College of Osteopathic Medicine
|Biddeford, Maine
|Active
| |
| rowspan="3" |Lambda
|
|Heritage College of Osteopathic Medicine
|Athens, Ohio
| rowspan="3" |Active
| rowspan="3" |[{{Cite web |title=Sigma Sigma Phi {{!}} Heritage College of Osteopathic Medicine |url=https://www.ohio.edu/medicine/about/offices/student-affairs/student-organizations/cleveland/sigma-sigma-phi |access-date=2025-05-15 |website=Ohio University}}] |
| September 2016
|Heritage College of Osteopathic Medicine, Dublin
|Dublin, Ohio |
| September 2019
|Heritage College of Osteopathic Medicine, Cleveland
|Cleveland, Ohio |
| rowspan="2" |Mu
|
|College of Osteopathic Medicine of the Pacific
|Pomona, California
| rowspan="2" |Active
| rowspan="2" | |
| |College of Osteopathic Medicine of the Pacific, Northwest
|Lebanon, Oregon |
| Nu
|
|West Virginia School of Osteopathic Medicine
|Lewisburg, West Virginia
|Active
|[{{Cite web |title=Sigma Sigma Phi |url=https://www.wvsom.edu/students/sigma-sigma-phi |access-date=2025-05-15 |website=West Virginia School of Osteopathic Medicine}}] |
| rowspan="2" |Xi
| rowspan="2" |
|Nova Southeastern College of Osteopathic Medicine
|Davie, Florida
| rowspan="2" |Active
| rowspan="2" | |
| Nova Southeastern College of Osteopathic Medicine, Clearwater
|Clearwater, Florida |
| rowspan="4" |Gamma (Second)
|May 8, 2002
|Lake Erie College of Osteopathic Medicine
|Erie, Pennsylvania
| rowspan="4" |Active
| rowspan="4" |[{{Cite web |title=Sigma Sigma Phi (SSP) – LECOM {{!}} SGA {{!}} Bradenton Medicine |url=https://com.bradenton.lecomsga.org/club-info/sigma-sigma-phi-national-osteopathic-service-fraternity-alpha-alpha-chapter/ |access-date=2025-05-15 |language=en-US}}][{{Cite web |date=2024-07-18 |title=LECOM at Seton Hill Chapter of Sigma Sigma Phi Hosts Inductions |url=https://lecom.edu/lecom-at-seton-hill-chapter-of-sigma-sigma-phi-hosts-inductions/ |access-date=2025-05-15 |website=Lake Erie College of Osteopathic Medicine |language=en-US}}] |
| February 2012
|Lake Erie College of Osteopathic Medicine at Bradenton
|Bradenton, Florida |
| October 2016
|Lake Erie College of Osteopathic Medicine at Seton Hill
|Greensburg, Pennsylvania |
| |Lake Erie College of Osteopathic Medicine at Elmira
|Elmira, New York |
| Omicron
|October 12, 2003
|Rowan-Virtua School of Osteopathic Medicine
|Stratford, New Jersey
|Active
|{{Efn|Chapter was chartered at the University of Medicine & Dentistry of New Jersey School of Osteopathic Medicine, now Rowan-Virtua School of Osteopathic Medicine.}} |
| Pi
|
|Touro University College of Osteopathic Medicine, Nevada
|Henderson, Nevada
|Inactive
| |
| Rho
|
|Arizona College of Osteopathic Medicine
|Glendale, Arizona
|Active
| |
| Sigma
|October 12, 2003
|University of Pikeville Kentucky College of Osteopathic Medicine
|Pikesville, Kentucky
|Active
| |
| rowspan="2" |Tau
|October 2006
|Touro University California College of Osteopathic Medicine
|Vallejo, California
| rowspan="2" |Active
| rowspan="2" | |
| October 2009
|Touro University California College of Osteopathic Medicine, Henderson
|Henderson, Nevada |
| Upsilon
|
|A.T. Still University: School of Osteopathic Medicine in Arizona
|Mesa, Arizona
|Active
| |
| Phi
|February 2008
|Lincoln Memorial University - DeBusk College of Osteopathic Medicine
|Harrogate, Tennessee
|Active
| |
| rowspan="3" |Chi
|October 2006
|Edward Via College of Osteopathic Medicine
|Blacksburg, Virginia
| rowspan="3" |Active
| rowspan="3" | |
| October 2012
|Edward Via College of Osteopathic Medicine, Carolinas Campus
|Spartanburg, South Carolina |
| Fall 2015
|Edward Via College of Osteopathic Medicine, Auburn Campus
|Auburn, Alabama |
| rowspan="3" |Psi
|
|Touro University College of Osteopathic Medicine, New York
|Harlem, New York City, New York
| rowspan="3" |Active
| rowspan="3" |[{{Cite web |title=Touro Sigma Sigma Phi, Psi Chapter |url=https://corbinslegacy.org/support/partner/touro-sigma-sigma-phi-psi-chapter/ |access-date=2025-05-15 |website=Corbin's Legacy |language=en-US}}] |
| February 2017
|Touro University College of Osteopathic Medicine, Middletown
|Middletown, New York |
| |Touro University College of Osteopathic Medicine, Great Falls
|Great Falls, Montana |
| rowspan="2" |Omega
|19xx ?–xxxx ?; February 16, 2008
|New York Institute of Technology College of Osteopathic Medicine
|Old Wesbury, New York
| rowspan="2" |Active
| rowspan="2" | |
| Spring 2019
|New York Institute of Technology College of Osteopathic Medicine, Jonesboro Campus
|Jonesboro, Arkansas |
| Alpha Alpha
|
|Lake Erie College of Osteopathic Medicine, Bradenton Campus
|Bradenton, Florida
|Inactive
| |
| Gamma Delta
|April 2011
|Pacific Northwest University College of Osteopathic Medicine
|Yakima, Washington
|Active
| |
| rowspan="2" |Omicron Theta
|September 2011
|Rocky Vista University College of Osteopathic Medicine
|Englewood, Colorado
| rowspan="2" |Active
| rowspan="2" | |
| September 2019
|Rocky Vista University College of Osteopathic Medicine, Ivins Campus
|Ivins, Utah |
| Alpha Mu
|October 2012
|William Carey University College of Osteopathic Medicine
|Hattiesburg, Mississippi
|Active
| |
| Mu Upsilon
|December 2014
|Marian University College of Osteopathic Medicine
|Indianapolis, Indiana
|Active
|[{{Cite web |title=Sigma Sigma Phi - Mu Upsilon Chapter |url=https://connect.marian.edu/Account/Login?ReturnUrl=%2Forganization%2Fsigma-sigma-phi-mu-upsilon-chapter |access-date=2025-05-15 |website=Marian University}}] |
| Alpha Omega
|February 2015
|Liberty University College of Osteopathic Medicine
|Lynchburg, Virginia
|Active
| |
| Alpha Beta
|June 2015
|Alabama College of Osteopathic Medicine
|Dothan, Alabama
|Active
| |
| Alpha Gamma
|
|College of Osteopathic Medicine, Sam Houston State University
|Huntsville, Texas
|Active
| |
| Alpha Lambda
|
|California Health Sciences University College of Osteopathic Medicine
|Clovis, California
|Active
| |
| Chi Upsilon
|August 2017
|Campbell University Jerry M Wallace School of Osteopathic Medicine
|Lillington, North Carolina
|Active
| |
| rowspan="2" |Beta Chi
|November 2017
|Burrell College of Osteopathic Medicine
|Las Cruces, New Mexico
| rowspan="2" |Active
| rowspan="2" |[{{Cite web |last=Salopek |first=Jessica |date=2017-10-14 |title=820+ Hours of Community Service and Counting: Sigma Sigma Phi Inducts 32 BCOM Students |url=https://burrell.edu/blog/2017/10/13/820-hours-of-community-service-and-counting-sigma-sigma-phi-inducts-32-bcom-students/ |access-date=2025-05-15 |website=Burrell College of Osteopathic Medicine |language=en-US}}][{{Cite news |date=2017-10-25 |title=BCOM Established Sigma Sigma Phi Chapter |url=https://www.newspapers.com/article/las-cruces-sun-news-bcom-established-sig/172413479/ |access-date=2025-05-15 |work=Las Cruces Sun-News |pages=A6 |via=Newspapers.com}}] |
| |Burrell College of Osteopathic Medicine, Melbourne
|Melbourne, Florida |
| Alpha Rho
|September 2018
|Arkansas College of Osteopathic Medicine
|Fort Smith, Arkansas
|Active
| |
| Alpha Psi
|
|University of the Incarnate Word School of Osteopathic Medicine
|San Antonio, Texas
|Active
| |
| Zeta Alpha
|
|Philadelphia College of Osteopathic Medicine, Georgia Campus
|Suwanee, Georgia
|
| |
| Iota Delta
|
|Idaho College of Osteopathic Medicine
|Meridian, Idaho
|Active
| |
| Kappa Chi
|202x ?
|Kansas College of Osteopathic Medicine
|Wichita, Kansas
|Active
| |