List of immunofluorescence findings for autoimmune bullous conditions
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{{see also|List of cutaneous conditions}}
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Several cutaneous conditions can be diagnosed with the aid of immunofluorescence studies.
Cutaneous conditions with positive direct or indirect immunofluorescence when using salt-split skin include:
| class="wikitable"
|+ Antibody isotype(s) and location of antibody deposition in immunofluorescence studies using salt-split skin for autoimmune bullous conditions targeting the basement membrane zone of the human integumentary system | ||
| Condition | Antibody isotype(s) deposited | Localization of antibody with use of salt-split skin |
|---|---|---|
| Antiepilegrin cicatricial pemphigoid | IgG | Dermal |
| Bullous lupus erythematosus | Dermal | |
| Bullous pemphigoid | IgG | Epidermal |
| Cicatricial pemphigoid | IgG | Epidermal |
| Epidermolysis bullosa acquisita | IgG | Dermal |
| Linear IgA bullous dermatosis | IgA | Epidermal |
| Orf-induced immunobullous disease | IgG | Dermal |
| Pemphigoid gestationis | IgG | Epidermal |
For several subtypes of pemphigus a variety of substrates are used for indirect immunofluorescence:
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|+ Substrates used in indirect immunofluorescence studies for the different pemphigus variants | |
| Pemphigus variant | Substrate |
|---|---|
| Pemphigus foliaceous | Guinea pig esophagus |
| Pemphigus vulgaris | Monkey esophagus |
| IgA pemphigus | Cultured skin |
| Paraneoplastic pemphigus | Rat bladder |
See also
References
{{reflist}}
- {{cite book |author=Bolognia, Jean L.|title=Dermatology |publisher=Mosby |location=St. Louis |year=2007 |isbn=1-4160-2999-0 |display-authors=etal}}
- {{cite book |author=James, William D.|title=Andrews' Diseases of the Skin: Clinical Dermatology |publisher=Saunders Elsevier |year=2006 |isbn=0-7216-2921-0 |display-authors=etal}}
{{DEFAULTSORT:Immunofluorescence findings for autoimmune bullous conditions}}