List of number-one singles of 2000 (Spain)
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This is a list of the Spanish PROMUSICAE Top 20 Singles number-ones of 2000.{{cite book |last=Salaverri|first=Fernando|title=Sólo éxitos: año a año, 1959–2002|edition=1st |date=September 2005|publisher=Fundación Autor-SGAE|location=Spain|isbn=8480486392}}
Chart history
| class="wikitable"
! Issue Date !! Song !! Artist | ||
| 1 January | rowspan=4| Rhythm Divine | rowspan=4| Enrique Iglesias |
| 8 January | ||
| 15 January | ||
| 22 January | ||
| 29 January | Infinito | Bunbury |
| 5 February | C'est la Vie (Always 21) | Ace of Base |
| 12 February | What a Girl Wants | Christina Aguilera |
| 19 February | Cartoon Heroes | Aqua |
| 26 February | Go Let It Out | Oasis |
| 4 March | rowspan=2| The Bad Touch | rowspan=2| Bloodhound Gang |
| 11 March | ||
| 18 March | rowspan=2| American Pie | rowspan=2| Madonna |
| 25 March | ||
| 1 April | rowspan=3| Sobreviviré | rowspan=3| Mónica Naranjo |
| 8 April | ||
| 15 April | ||
| 22 April | Agustito (Ketama Goes to Miami Remix) | Ketama |
| 29 April | Sobreviviré | Mónica Naranjo |
| 6 May | rowspan=2| No Me Dejes de Querer | rowspan=2| Gloria Estefan |
| 13 May | ||
| 20 May | It's My Life | Bon Jovi |
| 27 May | Oops!... I Did It Again | Britney Spears |
| 3 June | rowspan=5| Sex Machine (Get Up I Feel Like Being Like A Sex Machine) | rowspan=5| Tony Sweat |
| 10 June | ||
| 17 June | ||
| 24 June | ||
| 1 July | ||
| 8 July | It's My Life | Bon Jovi |
| 15 July | Ya no quiero tu querer | José el Francés |
| 22 July | rowspan=2| If You Leave Me Now | rowspan=2| Mónica Naranjo |
| 29 July | ||
| 5 August | rowspan=3| Boom Boom | rowspan=3| Chayanne |
| 12 August | ||
| 19 August | ||
| 26 August | rowspan=2| Ya no quiero tu querer | rowspan=2| José el Francés |
| 2 September | ||
| 9 September | rowspan=5| Music | rowspan=5| Madonna |
| 16 September | ||
| 23 September | ||
| 30 September | ||
| 7 October | ||
| 14 October | rowspan=2| Lady (Hear Me Tonight) | rowspan=2| Modjo |
| 21 October | ||
| 28 October | rowspan=4| Beautiful Day | rowspan=4| U2 |
| 4 November | ||
| 11 November | ||
| 18 November | ||
| 25 November | rowspan=6| No cambié | rowspan=6| Tamara |
| 2 December | ||
| 9 December | ||
| 16 December | ||
| 23 December | ||
| 30 December |