| class="wikitable sortable"
|+
!Year
!Manufacturer
!Synthesizer
!Notes
!Ref. |
| 1963
|Buchla
|Buchla Model 100 Series
|
|[{{Cite web|title=Buchla 200e: Part 1|url=https://www.soundonsound.com/reviews/buchla-200e-part-1|access-date=2020-08-08|website=www.soundonsound.com}}] |
| 1965
|Moog Music
|Moog synthesizer
|First commercial synthesizer
|[{{Cite web|url=https://www.theguardian.com/music/2010/aug/02/moog-synthesisers|title=Hey, what's that sound: Moog synthesisers|last=McNamee|first=David|date=2 August 2010|website=The Guardian|language=en|access-date=8 January 2020}}] |
| 1970
|Moog Music
|Minimoog
|First synthesizer sold in retail stores[{{Cite book|last1=PINCH|first1=T. J.|url=https://books.google.com/books?id=CoUs2SSvG4EC&dq=minimoog&pg=PT230|title=Analog Days: The Invention and Impact of the Moog Synthesizer|last2=Trocco|first2=Frank|last3=Pinch|first3=T. J.|date=2009-06-30|publisher=Harvard University Press|isbn=9780674042162|language=en}}]
|[{{Cite news|url=https://www.washingtonpost.com/wp-dyn/content/article/2005/08/22/AR2005082200373.html|title=Robert Moog Dies; Created Electronic Synthesizer|last=Bernstein|first=Adam|newspaper=The Washington Post |date=2005-08-23|access-date=2018-12-03|language=en-US|issn=0190-8286}}] |
| 1970
|Buchla
|Buchla Series 200
|
| |
| 1978
|Sequential Circuits
|Prophet-5
|First fully programmable polyphonic synthesizer
|[{{Cite web|url=https://www.factmag.com/2016/09/15/14-most-important-synths/|title=The 14 most important synths in electronic music history – and the musicians who use them|date=2016-09-15|website=FACT Magazine: Transmissions from the underground|language=en-US|access-date=2020-01-20}}] |
| 2008
|Dave Smith Instruments
|Prophet '08
|
|[{{Cite web|title=Dave Smith Instruments Prophet 08|url=https://www.soundonsound.com/reviews/dave-smith-instruments-prophet-08|access-date=2021-05-01|website=www.soundonsound.com}}] |
| 2017
|Dave Smith Instruments
|Prophet Rev 2
|
|[{{Cite web|title=Dave Smith Instruments Prophet Rev 2|url=https://www.soundonsound.com/reviews/dsi-prophet-rev-2|access-date=2021-05-01|website=www.soundonsound.com}}] |
| 1983
|Yamaha
|DX7
|First commercially successful digital synthesizer
| |
| 1987
|Yamaha
|DX7II
|
|[{{Cite book|title=The Synthesizer|last=Vail|first=Mark|publisher=Oxford University Press|year=2014|isbn=978-0195394894|pages=59}}] |
| 1983
|Yamaha
|DX1
|
| |
| 1987
|Yamaha
|TX81Z
|
| |
| 1988
|Yamaha
|DX11
|
| |
| 1985
|Yamaha
|DX21
|
| |
| 1981
|Roland
|TB-303
|Important to the development of acid house
|[{{Cite news|url=https://www.forbes.com/sites/jasperhamill/2014/03/25/one-synth-to-rule-them-all-roland-takes-on-clones-with-reissue-of-legendary-tb-303/#346a468359d5|title=The world's most famous electronic instrument is back. Will anyone buy the reissued TB-303?|last=Hamill|first=Jasper|work=Forbes|access-date=2018-03-26|language=en}}] |
| 1982
|Roland
|SH-101
|
| |
| 1982
|Roland
|Juno-6 / Juno-60
|
|[{{Cite web|url=https://www.musictech.net/reviews/roland-juno-series/|title=The Roland Juno Series - Back To The Future|date=2016-07-15|website=MusicTech|language=en-GB|access-date=2020-01-28}}] |
| 1981
|Roland
|Jupiter-8
|
|[{{Cite web|url=https://www.soundonsound.com/people/history-roland-part-2|title=The History Of Roland: Part 2|website=www.soundonsound.com|access-date=2020-01-28}}] |
| 1983
|Roland
|JX-3P
|
| |
| 1984
|Roland
|Juno-106
|
| |
| 1985
|Roland
|Alpha Juno
|
|[{{Cite web|title=Roland Alpha Juno 1 & 2|url=https://www.soundonsound.com/reviews/roland-alpha-juno-1-2|access-date=2020-11-12|website=www.soundonsound.com}}] |
| 1987
|Roland
|D-50
|First synthesizer with digital reverb
|[{{Cite web|url=https://www.soundonsound.com/people/history-roland-part-3|title=The History Of Roland: Part 3|website=www.soundonsound.com|access-date=2020-07-15}}] |
| 1991
|Roland
|JD-800
|
|[{{Cite web|url=https://www.musicradar.com/news/tech/the-10-greatest-synthesizers-of-all-time-224433|title=The 10 greatest synthesizers of all time|last=Solida 2018-11-05T11:10:00Z|first=Scot|website=MusicRadar|language=en|access-date=2020-05-04}}] |
| 1981
|Korg
|Polysix
|
| |
| 1980
|Oberheim
|OB-Xa
|
|[{{Cite web|url=https://www.musicradar.com/news/tech/the-10-greatest-synthesizers-of-all-time-224433|title=The 10 greatest synthesizers of all time|last=Solida 2018-11-05T11:10:00Z|first=Scot|website=MusicRadar|language=en|access-date=2020-01-20}}] |
| 1988
|Korg
|M1
|Bestselling synthesizer in history
|[{{Cite web|url=https://www.soundonsound.com/reviews/korg-m1-retrozone|title=Korg M1 (Retrozone)|last=Vail|first=Mark|date=February 2002|website=Sound on Sound|access-date=6 November 2019}}] |
| 1990
|Korg
|Wavestation
|
| |
| 1979
|Fairlight
|Fairlight CMI
|
| |
| 1971
|ARP
|ARP 2600
|
| |
| 1972
|ARP
|ARP Odyssey
|First duophonic synthesizer (capable of playing two notes at once)
| |
| 1975
|Moog Music
|Polymoog
|
|[{{Cite web|url=http://www.soundonsound.com/sos/jun98/articles/polymoog.html|title=Moog Polymoog|date=July 1998|website=Sound on Sound|url-status=live|archive-url=https://web.archive.org/web/20150524115105/http://www.soundonsound.com/sos/jun98/articles/polymoog.html|archive-date=2015-05-24|access-date=2020-01-20}}] |
| 1969
|EMS
|VCS3
|
| |
| 1976
|Yamaha
|CS-80
|
| |
| 1978
|Korg
|MS-20
|
| |
| 1981
|PPG
|Wave
|
| |
| 1991
|Korg
|01/W
|
|[{{Cite web|title=The History Of Korg: Part 2|url=https://www.soundonsound.com/music-business/history-korg-part-2|access-date=2022-01-03|website=www.soundonsound.com}}] |
| 1997
|Propellerhead Software
|ReBirth
|One of the first software synthesizers that could be played in real time via MIDI
|[{{Cite book|last=Vail|first=Mark|title=The Synthesizer|publisher=Oxford University Press|year=2014|isbn=978-0195394894}}] |
| 1996
|Roland
|JP-8000
|Supersaw technology helped popularise trance music.
|[{{Cite web |last=Scarth |first=Greg |date=2014-11-24 |title=Ten Of The Best: First Vintage Synths |url=https://www.attackmagazine.com/reviews/the-best/ten-best-first-vintage-synths/ |access-date=2022-12-03 |website=Attack Magazine |language=en-US}}] |