Lithium aspartate

{{Short description|Chemical compound}}

{{cs1 config|name-list-style=vanc|display-authors=6}}

{{Use dmy dates|date=December 2024}}

{{Drugbox

| image = Lithium aspartate.svg

| image_class = skin-invert-image

| tradename =

| Drugs.com = {{drugs.com|monograph|lithium-salts}}

| legal_status = OTC

| routes_of_administration = Oral

| pregnancy_US = X

| CAS_number_Ref = {{cascite|correct|CAS}}

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = L2N7Z24B30

| CAS_number = 70962-88-8

| PubChem = 71587253

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = 34994320

| smiles = [Li+].N[C@@H](CC(O)=O)C([O-])=O

| StdInChI_Ref = {{stdinchicite|changed|chemspider}}

| StdInChI = InChI=1S/C4H7NO4.Li/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H,6,7)(H,8,9);/q;+1/p-1/t2-;/m0./s1

| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}

| StdInChIKey = NFNOWBZQMRFQDG-DKWTVANSSA-M

| C=4 | H=6 | Li=1 | N=1 | O=4

}}

Lithium aspartate (C₄H₆LiNO₄) is a salt of aspartic acid and lithium. It is sometimes marketed as a dietary supplement used in small doses to treat certain medical conditions; however, there are no systematic reviews supporting the efficacy, or safety of lithium aspartate and it is not approved by the U.S. Food and Drug Administration (FDA) for the treatment of any medical condition. Published research on lithium aspartate is sparse.{{cite journal |vauthors=Müller-Oerlinghausen B, Imiela M |title=Is lithium aspartate at low serum levels more effective than the usual lithium salts? |journal=Nervenarzt. |volume=57 |issue=6 |pages=370–3 |date=June 1986 |pmid=3736729 }}{{cite journal |vauthors=Olbrich R, Watzl H, Völter M, Siedow H |title=Lithium in the treatment of chronic alcoholic patients with brain damage--a controlled study |journal=Nervenarzt. |volume=62 |issue=3 |pages=182–6 |date=March 1991 |pmid= 2052117 }}{{cite journal |author=Daunderer M |title=Lithium aspartate in drug dependence |journal=Fortschr. Med. |volume=100 |issue=33 |pages=1500–2 |date=September 1982 |pmid= 7129311 }}

Aspartic acid stimulates the NMDA receptor.{{cite journal | vauthors = Chen PE, Geballe MT, Stansfeld PJ, Johnston AR, Yuan H, Jacob AL, Snyder JP, Traynelis SF, Wyllie DJ | title = Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling | journal = Molecular Pharmacology | volume = 67 | issue = 5 | pages = 1470–84 | date = May 2005 | pmid = 15703381 | doi = 10.1124/mol.104.008185 | s2cid = 13505187 | url = http://molpharm.aspetjournals.org/cgi/content/full/67/5/1470 }}