Lithium citrate

{{chembox

| ImageFile = Lithiumcitrat V2.svg

| ImageClass = skin-invert-image

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 400144718

| Name = Lithium citrate

| OtherNames = Trilithium citrate
trilithium 2-hydroxypropane-1,2,3-tricarboxylate

|Section1={{Chembox Identifiers

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 12932

| ChEBI = 64735

| ChEMBL_Ref = {{ebicite|correct|EBI}}

| ChEMBL = 1201170

| DrugBank = DB14507

| EC_number = 213-045-8

| InChI = 1/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3

| InChIKey = WJSIUCDMWSDDCE-DFZHHIFOAV

| SMILES = [Li+].[Li+].[Li+].O=C([O-])CC(O)(C([O-])=O)CC(=O)[O-]

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = WJSIUCDMWSDDCE-UHFFFAOYSA-K

| CASNo_Ref = {{cascite|correct|??}}

| CASNo = 919-16-4

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 3655633623

| RTECS = TZ8616000

| PubChem = 13520

}}

|Section2={{Chembox Properties

| Formula = Li₃C₆H₅O₇

| MolarMass = 209.923 g mol⁻¹

| Appearance = Odorless white powder

| Density =

| MeltingPt = decomposes at

| MeltingPtC = 105

}}

|Section7={{Chembox Hazards

| MainHazards =

| FlashPt = N/A

| GHSPictograms = {{GHS07}}

| GHSSignalWord = Warning

| HPhrases = {{H-phrases|302|319}}

| PPhrases = {{P-phrases|305+351+338}}

}}

Lithium citrate (Li₃C₆H₅O₇) is a lithium salt of citric acid that is used as a mood stabilizer in psychiatric treatment of manic states and bipolar disorder.[http://www.medbroadcast.com/drug/getdrug/pms-lithium-citrate Medication description]{{Cite web |title=pms-Lithium Citrate - Uses, Side Effects, Interactions - MedBroadcast.com |url=https://medbroadcast.com/drug/getdrug/pms-lithium-citrate |access-date=2017-08-15 |website=medbroadcast.com}}{{cite web|url=https://www.nami.org/Template.cfm?Section=About_Medications&Template=/TaggedPage/TaggedPageDisplay.cfm&TPLID=51&ContentID=20820|title=Medical use|archive-url=https://web.archive.org/web/20060615120040/http://www.nami.org/Template.cfm?Section=About_Medications&Template=%2FTaggedPage%2FTaggedPageDisplay.cfm&TPLID=51&ContentID=20820 |access-date=2006-07-29 |archive-date=2006-06-15 }}{{Cite web |date=2020-08-17 |title=Lithium: medicine to control mood disorders such as mania and bipolar disorder |url=https://www.nhs.uk/medicines/lithium/ |access-date=2022-08-25 |website=nhs.uk}} There is extensive pharmacology of lithium, the active component of this salt.

History

Lithium citrate was one of the lithium salts used to add lithium to drinks and water (lithia water) in the late 19th century and the early 20th century, when there was a general health craze for lithium with it believed to be a cure-all.{{cite journal |title=Lithium: Proving Its Mettle for 50 Years |journal=JAMA |date=23 June 1999 |volume=281 |issue=24 |pages=2271 |doi=10.1001/jama.281.24.2271}} The soft drink 7Up was at one point named "7Up Lithiated Lemon Soda" when it was formulated in 1929 because it claimed to contain lithium citrate. The beverage was a patent medicine marketed as a cure for hangover. In 1936 the federal government forced the manufacturer to remove a number of health claims, and because "lithium was not an actual ingredient", the name was changed to just "7 Up" in 1937.{{Cite journal |last1=Lockhart |first1=Bill |last2=Brown |first2=Bob |date=2024 |title=The Seven-Up Company and 7-Up Bottles The Real Story: A Look at the Myths, the Mystery, and the Magic |url=https://sha.org/bottle/pdffiles/7-UpStudy1.pdf |journal=Society for Historical Archaeology}} [https://sha.org/bottle/pdffiles/7-UpStudy2.pdf Chapter 1] [https://sha.org/bottle/pdffiles/7-UpStudy2.pdf Chapter 2]{{rp|§2}} Many sources repeat an incorrect version of the story where the name is "Bib-Label Lithiated Lemon-Lime Soda" and the removal happened in 1948 due to a Food and Drug Administration ban.{{Cite book | last = Gielen | first = Marcel | author2 = Edward R. T. Tiekink | title = Metallotherapeutic drugs and metal-based diagnostic agents: The use of metals in medicine | url = https://archive.org/details/metallotherapeut00giel | url-access = limited | publisher = John Wiley and Sons | year = 2005 | page = [https://archive.org/details/metallotherapeut00giel/page/n92 3] | isbn = 0-470-86403-6 }}{{cite web | url=https://time.com/4231522/7up-lithium-chemical-reaction/ | title=Here's the Gross Thing That Happens when You Mix 7-Up with Lithium | publisher= Time, Inc. | date=2016-02-20 | access-date= 2024-12-11}}

Lithium citrate is used as a mood stabilizer and is used to treat mania, hypomania, depression and bipolar disorder.{{Cite web |last=PubChem |title=Lithium citrate |url=https://pubchem.ncbi.nlm.nih.gov/compound/13520 |access-date=2022-09-08 |website=pubchem.ncbi.nlm.nih.gov}} It can be administered orally in the form of a syrup.

References

Category:Citrates

Category:Lithium salts

Category:Mood stabilizers

Category:Organolithium compounds