Lymphotoxin beta receptor

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphotoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis.

Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. LTBR is also essential for development and organization of the secondary lymphoid organs and chemokine release.{{cite journal |vauthors=Chang YH, Hsieh SL, Chen MC, Lin WW | title = Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation | journal = Exp. Cell Res. | volume = 278 | issue = 2 | pages = 166–74 |date=August 2002 | pmid = 12169272 | doi = 10.1006/excr.2002.5573 }}

The Ramachandran plots show that 64.6% of all residues were in a favored region.

This structure was found using X-ray diffraction. The resolution is 3.50 angstroms.

The alpha and beta angles are 90 degrees while the gamma angle is 120 degrees.{{cite web |url=http://www.rcsb.org/pdb/images/1RF3_ram_m_500.pdf |title=MolProbity Ramachandran analysis |archive-url=https://web.archive.org/web/20121012104917/http://www.rcsb.org/pdb/images/1RF3_ram_m_500.pdf |archive-date=2012-10-12 |url-status=dead }}

Lymphotoxin beta receptor has been shown to interact with Diablo homolog{{cite journal |last=Kuai |first=Jun |author2=Nickbarg Elliott |author3=Wooters Joe |author4=Qiu Yongchang |author5=Wang Jack |author6=Lin Lih-Ling |date=Apr 2003 |title=Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis |journal=J. Biol. Chem. |volume=278 |issue=16 |pages=14363–9 |location = United States| issn = 0021-9258| pmid = 12571250 |doi = 10.1074/jbc.M208672200 |doi-access=free }} and TRAF3.{{cite journal |doi=10.1073/pnas.94.6.2460 |last=VanArsdale |first=T L |author2=VanArsdale S L |author3=Force W R |author4=Walter B N |author5=Mosialos G |author6=Kieff E |author7=Reed J C |author8=Ware C F |author-link6=Elliott D. Kieff|date=Mar 1997 |title=Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue=6 |pages=2460–5 |location = UNITED STATES| issn = 0027-8424| pmid = 9122217 | bibcode =1997PNAS...94.2460V |pmc=20110 |doi-access=free }}{{cite journal |doi=10.1074/jbc.274.17.11868 |last=Wu |first=M Y |author2=Wang P Y |author3=Han S H |author4=Hsieh S L |date=Apr 1999 |title=The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells |journal=J. Biol. Chem. |volume=274 |issue=17 |pages=11868–73 |location = UNITED STATES| issn = 0021-9258| pmid = 10207006 |doi-access=free }}{{cite journal |doi=10.1074/jbc.272.22.14029 |last=Marsters |first=S A |author2=Ayres T M |author3=Skubatch M |author4=Gray C L |author5=Rothe M |author6=Ashkenazi A |date=May 1997 |title=Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1 |journal=J. Biol. Chem. |volume=272 |issue=22 |pages=14029–32 |location = UNITED STATES| issn = 0021-9258| pmid = 9162022 |doi-access=free }}

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{{refend}}

• {{MeshName|Lymphotoxin+beta+Receptor}}

{{Cytokine receptors}}

{{TNF receptor superfamily modulators}}

Category:TNF receptor family