MAGI3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 is an enzyme that in humans is encoded by the MAGI3 gene.{{cite journal |vauthors=Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 7 | issue = 4 | pages = 273–81 |date=Dec 2000 | pmid = 10997877 | doi = 10.1093/dnares/7.4.271| doi-access = free }}{{cite journal |vauthors=Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, Lasky LA | title = Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase | journal = J Biol Chem | volume = 275 | issue = 28 | pages = 21477–85 |date=Aug 2000 | pmid = 10748157 | doi = 10.1074/jbc.M909741199 | doi-access = free }}{{cite web | title = Entrez Gene: MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=260425}}
Interactions
MAGI3 has been shown to interact with PTPRB{{cite journal |doi=10.1242/jcs.00302 |last=Adamsky |first=Konstantin |author2=Arnold Katya |author3=Sabanay Helena |author4=Peles Elior |date=Apr 2003 |title=Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins |journal=J. Cell Sci. |volume=116 |issue=Pt 7 |pages=1279–89 | issn = 0021-9533| pmid = 12615970 |doi-access=free }} and PTEN.
References
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Further reading
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- {{cite journal |vauthors=Zhang H, Wang D, Sun H, etal |title=MAGI-3 regulates LPA-induced activation of Erk and RhoA. |journal=Cell. Signal. |volume=19 |issue= 2 |pages= 261–8 |year= 2007 |pmid= 16904289 |doi= 10.1016/j.cellsig.2006.06.008 | pmc=1995035 }}
- {{cite journal |vauthors=He J, Bellini M, Inuzuka H, etal |title=Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. |journal=J. Biol. Chem. |volume=281 |issue= 5 |pages= 2820–7 |year= 2006 |pmid= 16316992 |doi= 10.1074/jbc.M509503200 |doi-access= free }}
- {{cite journal |vauthors=Franklin JL, Yoshiura K, Dempsey PJ, etal |title=Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. |journal=Exp. Cell Res. |volume=303 |issue= 2 |pages= 457–70 |year= 2005 |pmid= 15652357 |doi= 10.1016/j.yexcr.2004.10.007 }}
- {{cite journal |vauthors=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. |journal=Oncogene |volume=23 |issue= 36 |pages= 6023–30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817 |doi-access= free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Adamsky K, Arnold K, Sabanay H, Peles E |title=Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins. |journal=J. Cell Sci. |volume=116 |issue= Pt 7 |pages= 1279–89 |year= 2003 |pmid= 12615970 |doi=10.1242/jcs.00302 |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }}
- {{cite journal |vauthors=Thomas M, Laura R, Hepner K, etal |title=Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. |journal=Oncogene |volume=21 |issue= 33 |pages= 5088–96 |year= 2002 |pmid= 12140759 |doi= 10.1038/sj.onc.1205668 |doi-access= free }}
- {{cite journal |vauthors=Laura RP, Ross S, Koeppen H, Lasky LA |title=MAGI-1: a widely expressed, alternatively spliced tight junction protein. |journal=Exp. Cell Res. |volume=275 |issue= 2 |pages= 155–70 |year= 2002 |pmid= 11969287 |doi= 10.1006/excr.2002.5475 }}
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