MALAT1

Transcripts of MALAT1 are significantly increased in the cerebellum of human alcoholics, as well as in similar regions of rat brains after the withdrawal of ethanol vapours. This alcohol-induced upregulation of MALAT1 may be responsible for differential expression of a number of proteins which contribute to ethanol tolerance and dependency in humans.{{cite journal | vauthors = Kryger R, Fan L, Wilce PA, Jaquet V | title = MALAT-1, a non protein-coding RNA is upregulated in the cerebellum, hippocampus and brain stem of human alcoholics | journal = Alcohol | volume = 46 | issue = 7 | pages = 629–634 | date = November 2012 | pmid = 22560368 | doi = 10.1016/j.alcohol.2012.04.002 }}

Elevated MALAT1 expression is correlated with poor overall survival in various types of cancer, suggesting that this gene is a prognostic factor for different types of cancer.{{cite journal | vauthors = Tian X, Xu G | title = Clinical value of lncRNA MALAT1 as a prognostic marker in human cancer: systematic review and meta-analysis | journal = BMJ Open | volume = 5 | issue = 9 | pages = e008653 | year = 2015 | pmid = 26423854 | pmc = 4593150 | doi = 10.1136/bmjopen-2015-008653 | url = }} {{open access}}{{cite journal | vauthors = Wei Y, Niu B | title = Role of MALAT1 as a Prognostic Factor for Survival in Various Cancers: A Systematic Review of the Literature with Meta-Analysis | journal = Disease Markers | volume = 2015 | pages = 164635 | year = 2015 | pmid = 26420912 | pmc = 4572489 | doi = 10.1155/2015/164635 | doi-access = free }}{{Creative Commons text attribution notice|cc=by4|from this source=yes}}

• Long non-coding RNA
• MALAT1-associated small cytoplasmic RNA

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• {{cite journal | vauthors = Ji Q, Liu X, Fu X, Zhang L, Sui H, Zhou L, Sun J, Cai J, Qin J, Ren J, Li Q | title = Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway | journal = PLOS ONE | volume = 8 | issue = 11 | pages = e78700 | date = Nov 2013 | pmid = 24244343| doi = 10.1371/journal.pone.0078700 | pmc = 3823921 | bibcode = 2013PLoSO...878700J | doi-access = free }} {{open access}}
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• [https://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607924 OMIM page for MALAT1]
• [https://www.genenames.org/data/hgnc_data.php?hgnc_id=29665 HGNC page for MALAT1] {{Webarchive|url=https://web.archive.org/web/20130917153912/https://www.genenames.org/data/hgnc_data.php?hgnc_id=29665 |date=2013-09-17 }}
• {{Rfam|id=RF01871|name=Metastasis associated lung adenocarcinoma transcript 1}}
• [https://kb.10xgenomics.com/hc/en-us/articles/360004729092-Why-do-I-see-high-levels-of-Malat1-in-my-gene-expression-data- Relevance of MALAT1 in single-cell RNA sequencing data]

Category:LncRNA