MAML1

This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.

Details on the activity of the N-terminal domain of Mastermind-like protein 1

may be found under MamL-1.

MAML1 has been shown to interact with EP300{{cite journal | vauthors = Wallberg AE, Pedersen K, Lendahl U, Roeder RG | title = p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro | journal = Mol. Cell. Biol. | volume = 22 | issue = 22 | pages = 7812–9 | date = Nov 2002 | pmid = 12391150 | pmc = 134732 | doi = 10.1128/MCB.22.22.7812-7819.2002 }}{{cite journal | vauthors = Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA | title = Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex | journal = Genes Dev. | volume = 16 | issue = 11 | pages = 1397–411 | date = Jun 2002 | pmid = 12050117 | pmc = 186317 | doi = 10.1101/gad.991602 }} and NOTCH1.{{cite journal | vauthors = Wu L, Sun T, Kobayashi K, Gao P, Griffin JD | title = Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors | journal = Mol. Cell. Biol. | volume = 22 | issue = 21 | pages = 7688–700 | date = Nov 2002 | pmid = 12370315 | pmc = 135662 | doi = 10.1128/MCB.22.21.7688-7700.2002 }}

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• {{cite journal | vauthors = Alves-Guerra MC, Ronchini C, Capobianco AJ | title = Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival. | journal = Cancer Res. | volume = 67 | issue = 18 | pages = 8690–8 | year = 2007 | pmid = 17875709 | doi = 10.1158/0008-5472.CAN-07-1720 | doi-access = free }}
• {{cite journal | vauthors = Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, Gurumurthy CB, Germaniuk-Kurowska A, Reddi HV, Solomon A, Zeng MS, Kung A, Ma H, Gao Q, Dimri G, Stanculescu A, Miele L, Wu L, Griffin JD, Wazer DE, Band H, Band V | title = The notch regulator MAML1 interacts with p53 and functions as a coactivator. | journal = J. Biol. Chem. | volume = 282 | issue = 16 | pages = 11969–81 | year = 2007 | pmid = 17317671 | doi = 10.1074/jbc.M608974200 | url = https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1110&context=com_bio_articles | doi-access = free }}
• {{cite journal | vauthors = Nam Y, Sliz P, Song L, Aster JC, Blacklow SC | title = Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. | journal = Cell | volume = 124 | issue = 5 | pages = 973–83 | year = 2006 | pmid = 16530044 | doi = 10.1016/j.cell.2005.12.037 | s2cid = 17809522 | doi-access = free }}
• {{cite journal | vauthors = Fryer CJ, White JB, Jones KA | title = Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. | journal = Mol. Cell | volume = 16 | issue = 4 | pages = 509–20 | year = 2005 | pmid = 15546612 | doi = 10.1016/j.molcel.2004.10.014 | doi-access = free }}
• {{cite journal | vauthors = Nam Y, Weng AP, Aster JC, Blacklow SC | title = Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. | journal = J. Biol. Chem. | volume = 278 | issue = 23 | pages = 21232–9 | year = 2003 | pmid = 12644465 | doi = 10.1074/jbc.M301567200 | doi-access = free }}
• {{cite journal | vauthors = Wallberg AE, Pedersen K, Lendahl U, Roeder RG | title = p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. | journal = Mol. Cell. Biol. | volume = 22 | issue = 22 | pages = 7812–9 | year = 2002 | pmid = 12391150 | pmc = 134732 | doi = 10.1128/MCB.22.22.7812-7819.2002 }}
• {{cite journal | vauthors = Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M | title = Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling. | journal = J. Biol. Chem. | volume = 277 | issue = 52 | pages = 50612–20 | year = 2003 | pmid = 12386158 | doi = 10.1074/jbc.M209529200 | doi-access = free }}
• {{cite journal | vauthors = Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA | title = Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. | journal = Genes Dev. | volume = 16 | issue = 11 | pages = 1397–411 | year = 2002 | pmid = 12050117 | pmc = 186317 | doi = 10.1101/gad.991602 }}
• {{cite journal | vauthors = Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J | title = SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. | journal = Mol. Cell. Biol. | volume = 21 | issue = 21 | pages = 7403–15 | year = 2001 | pmid = 11585921 | pmc = 99913 | doi = 10.1128/MCB.21.21.7403-7415.2001 }}

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