MAP1LC3A

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B.

MAPLC3A is one of the mammalian homologues of yeast ATG8, an important marker and effector of autophagy.{{Cite journal|pmc = 4127242|title = Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer|vauthors=Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, Alabiso O, Arisio R, Katsaros D, Benedetto C, Isidoro C |date = 2014|journal = Biomed Res Int|doi = 10.1155/2014/462658|pmid = 25136588|volume = 2014|page = 462658|doi-access = free}}

MAP1LC3A is regulated by several post-translational modifications. These include covalent linkage of the C-terminus to phosphatidylethanolamine in autophagic membranes, and phosphorylation by protein kinase A,{{cite journal |vauthors=Cherra SJ, Kulich SM, Uechi G, Balasubramani M, Mountzouris J, Day BW, Chu CT | title = Regulation of the autophagy protein LC3 by phosphorylation | journal = J. Cell Biol. | volume = 190 | issue = 4 | pages = 533–9 |date=August 2010 | pmid = 20713600 | pmc = 2928022 | doi = 10.1083/jcb.201002108 }} which downregulates its autophagy functions. Noncovalent interactions are important for its cargo targeting functions in selective autophagy. For example, it has been shown to interact with sequestosome 1.{{cite journal |vauthors=Shvets E, Fass E, Scherz-Shouval R, Elazar Z | title = The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes | journal = J. Cell Sci. | volume = 121 | issue = Pt 16 | pages = 2685–95 |date=August 2008 | pmid = 18653543 | doi = 10.1242/jcs.026005 | doi-access = free }}

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