MAP3K13
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13 gene.{{cite journal | vauthors = Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T | title = Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain | journal = J Biol Chem | volume = 272 | issue = 45 | pages = 28622–9 | date = Dec 1997 | pmid = 9353328 | doi = 10.1074/jbc.272.45.28622 | doi-access = free }}{{cite web | title = Entrez Gene: MAP3K13 mitogen-activated protein kinase kinase kinase 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9175}}
Function
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.
Interactions
MAP3K13 has been shown to interact with PRDX3.{{cite journal | vauthors = Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T | title = Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically | journal = Eur. J. Biochem. | volume = 270 | issue = 1 | pages = 76–83 | date = Jan 2003 | pmid = 12492477 | doi = 10.1046/j.1432-1033.2003.03363.x | doi-access = free }}
References
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Further reading
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- {{cite journal | vauthors = Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T | title = Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically | journal = Eur. J. Biochem. | volume = 270 | issue = 1 | pages = 76–83 | year = 2003 | pmid = 12492477 | doi = 10.1046/j.1432-1033.2003.03363.x | doi-access = free }}
- {{cite journal | vauthors = Ikeda A, Sakuma H, Masaki M, Kozutsumi Y, Oka S, Inazawa J, Kawasaki T | title = Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene | journal = J. Biochem. Mol. Biol. Biophys. | volume = 6 | issue = 2 | pages = 113–7 | year = 2002 | pmid = 12186766 | doi = 10.1080/10258140290027243 }}
- {{cite journal | vauthors = Ikeda A, Hasegawa K, Masaki M, Moriguchi T, Nishida E, Kozutsumi Y, Oka S, Kawasaki T | title = Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway | journal = J. Biochem. | volume = 130 | issue = 6 | pages = 773–81 | year = 2002 | pmid = 11726277 | doi = 10.1093/oxfordjournals.jbchem.a003048 }}
- {{cite journal | vauthors = Ikeda A, Masaki M, Kozutsumi Y, Oka S, Kawasaki T | title = Identification and characterization of functional domains in a mixed lineage kinase LZK | journal = FEBS Lett. | volume = 488 | issue = 3 | pages = 190–5 | year = 2001 | pmid = 11163770 | doi = 10.1016/S0014-5793(00)02432-7 | s2cid = 44379847 | doi-access = free }}
- {{cite journal | vauthors = Schultz SJ, Nigg EA | title = Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans | journal = Cell Growth Differ. | volume = 4 | issue = 10 | pages = 821–30 | year = 1994 | pmid = 8274451 }}
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{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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