MAP4K2

The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. A recent study showed that MAP4K2 is a direct kinase of LATS1/2 and thus regulates the Hippo pathway effectors YAP and TAZ.{{Cite journal

| last1 = Meng

| first1 = Zhipeng

| last2 = Moroishi

| first2 = Toshiro

| last3 = Guan

| first3 = Kun-Liang

| date = 2016-01-01

| title = Mechanisms of Hippo pathway regulation

| journal = Genes & Development

| language = en

| volume = 30

| issue = 1

| pages = 1–17

| doi = 10.1101/gad.274027.115

| issn = 0890-9369

| pmc = 4701972

| pmid = 26728553

}}{{Cite journal

| last1 = Meng

| first1 = Zhipeng

| last2 = Moroishi

| first2 = Toshiro

| last3 = Mottier-Pavie

| first3 = Violaine

| last4 = Plouffe

| first4 = Steven W.

| last5 = Hansen

| first5 = Carsten G.

| last6 = Hong

| first6 = Audrey W.

| last7 = Park

| first7 = Hyun Woo

| last8 = Mo

| first8 = Jung-Soon

| last9 = Lu

| first9 = Wenqi

| date = 2015-10-05

| title = MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

| journal = Nature Communications

| language = en

| volume = 6

| pages = 8357

| doi = 10.1038/ncomms9357

| pmc = 4600732

| pmid = 26437443

| bibcode = 2015NatCo...6.8357M

}}

MAP4K2 has been shown to interact with RAB8A{{cite journal | vauthors = Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD | title = In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 10 | pages = 5151–5 | date = May 1996 | pmid = 8643544 | pmc = 39423 | doi = 10.1073/pnas.93.10.5151 | bibcode = 1996PNAS...93.5151R | doi-access = free }} and TRAF2.{{cite journal | vauthors = Yuasa T, Ohno S, Kehrl JH, Kyriakis JM | title = Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 35 | pages = 22681–92 | date = Aug 1998 | pmid = 9712898 | doi = 10.1074/jbc.273.35.22681 | doi-access = free }}

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{{refbegin | 2}}

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