MAPKAP1

{{Short description|Protein-coding gene in the species Homo sapiens}}

Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene.{{cite journal |vauthors=Schroder W, Cloonan N, Bushell G, Sculley T | title = Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene | journal = Gene | volume = 339 | pages = 17–23 |date=Sep 2004 | pmid = 15363842 | doi = 10.1016/j.gene.2004.07.001 }}{{cite web | title = Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79109}} As the name indicates, it is a subunit of mTOR complex 2.

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.

References

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{{cite journal |vauthors=Schroder W, Bushell G, Sculley T |title=The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins |journal=Cell. Signal. |volume=17 |issue= 6 |pages= 761–7 |year= 2005 |pmid= 15722200 |doi= 10.1016/j.cellsig.2004.10.015 }}
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{{cite journal | author=Cheng J |title=Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation |journal=Mol. Cell. Biol. |volume=25 |issue= 14 |pages= 5955–64 |year= 2005 |pmid= 15988011 |doi= 10.1128/MCB.25.14.5955-5964.2005 | pmc=1168836 | author2=Zhang D | author3=Kim K | last4=Zhao | first4=Y. | last5=Zhao | first5=Y. | last6=Su | first6=B. }}
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{{cite journal | author=Frias MA |title=mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s |journal=Curr. Biol. |volume=16 |issue= 18 |pages= 1865–70 |year= 2006 |pmid= 16919458 |doi= 10.1016/j.cub.2006.08.001 | author2=Thoreen CC | author3=Jaffe JD | last4=Schroder | first4=Wayne | last5=Sculley | first5=Tom | last6=Carr | first6=Steven A. | last7=Sabatini | first7=David M. |s2cid=8239162 | doi-access=free|bibcode=2006CBio...16.1865F }}
{{cite journal | author=Jacinto E |title=SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity |journal=Cell |volume=127 |issue= 1 |pages= 125–37 |year= 2006 |pmid= 16962653 |doi= 10.1016/j.cell.2006.08.033 | author2=Facchinetti V | author3=Liu D | last4=Soto | first4=Nelyn | last5=Wei | first5=Shiniu | last6=Jung | first6=Sung Yun | last7=Huang | first7=Qiaojia | last8=Qin | first8=Jun | last9=Su | first9=Bing |s2cid=230319 | doi-access=free }}
{{cite journal |vauthors=Yang Q, Inoki K, Ikenoue T, Guan KL |title=Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity |journal=Genes Dev. |volume=20 |issue= 20 |pages= 2820–32 |year= 2006 |pmid= 17043309 |doi= 10.1101/gad.1461206 | pmc=1619946 }}
{{cite journal | author=Makino C |title=Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway |journal=Genes Cells |volume=11 |issue= 11 |pages= 1239–51 |year= 2007 |pmid= 17054722 |doi= 10.1111/j.1365-2443.2006.01016.x | author2=Sano Y | author3=Shinagawa T | last4=Millar | first4=Jonathan B. A. | last5=Ishii | first5=Shunsuke |s2cid=10605647 |doi-access=free }}
{{cite journal | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 | author2=Blagoev B | author3=Gnad F | last4=Macek | first4=Boris | last5=Kumar | first5=Chanchal | last6=Mortensen | first6=Peter | last7=Mann | first7=Matthias |s2cid=7827573 | doi-access=free}}
{{cite journal | author=Schroder WA |title=Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling |journal=Cell. Signal. |volume=19 |issue= 6 |pages= 1279–89 |year= 2007 |pmid= 17303383 |doi= 10.1016/j.cellsig.2007.01.013 | author2=Buck M | author3=Cloonan N | last4=Hancock | first4=John F. | last5=Suhrbier | first5=Andreas | last6=Sculley | first6=Tom | last7=Bushell | first7=Gillian }}

MAPKAP1

References

Further reading