MAPRE2

The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.

MAPRE2 has been shown to interact with APC.{{cite journal | vauthors = Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW | title = APC binds to the novel protein EB1 | journal = Cancer Res. | volume = 55 | issue = 14 | pages = 2972–7 | date = Jul 1995 | pmid = 7606712 }}{{cite journal | vauthors = Nakamura M, Zhou XZ, Lu KP | title = Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization | journal = Curr. Biol. | volume = 11 | issue = 13 | pages = 1062–7 | date = Jul 2001 | pmid = 11470413 | doi = 10.1016/S0960-9822(01)00297-4 | s2cid = 14122895 | doi-access = free | bibcode = 2001CBio...11.1062N }}

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• {{cite journal | vauthors = Tirnauer JS, Bierer BE | title = EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability | journal = J. Cell Biol. | volume = 149 | issue = 4 | pages = 761–6 | year = 2000 | pmid = 10811817 | pmc = 2174556 | doi = 10.1083/jcb.149.4.761 }}
• {{cite journal | vauthors = Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW | title = APC binds to the novel protein EB1 | journal = Cancer Res. | volume = 55 | issue = 14 | pages = 2972–7 | year = 1995 | pmid = 7606712 }}
• {{cite journal | vauthors = Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE | title = The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 18 | pages = 10596–601 | year = 1998 | pmid = 9724749 | pmc = 27940 | doi = 10.1073/pnas.95.18.10596 | bibcode = 1998PNAS...9510596B | doi-access = free }}
• {{cite journal | vauthors = Morrison EE, Wardleworth BN, Askham JM, Markham AF, Meredith DM | title = EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle | journal = Oncogene | volume = 17 | issue = 26 | pages = 3471–7 | year = 1999 | pmid = 10030671 | doi = 10.1038/sj.onc.1202247 | s2cid = 25818701 | doi-access = }}
• {{cite journal | vauthors = Juwana JP, Henderikx P, Mischo A, Wadle A, Fadle N, Gerlach K, Arends JW, Hoogenboom H, Pfreundschuh M, Renner C | title = EB/RP gene family encodes tubulin binding proteins | journal = Int. J. Cancer | volume = 81 | issue = 2 | pages = 275–84 | year = 1999 | pmid = 10188731 | doi = 10.1002/(SICI)1097-0215(19990412)81:2<275::AID-IJC18>3.0.CO;2-Z | s2cid = 33232892 | doi-access = free }}
• {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2001 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
• {{cite journal | vauthors = Nakamura M, Zhou XZ, Lu KP | title = Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization | journal = Curr. Biol. | volume = 11 | issue = 13 | pages = 1062–7 | year = 2001 | pmid = 11470413 | doi = 10.1016/S0960-9822(01)00297-4 | s2cid = 14122895 | doi-access = free | bibcode = 2001CBio...11.1062N }}
• {{cite journal | vauthors = Askham JM, Vaughan KT, Goodson HV, Morrison EE | title = Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome | journal = Mol. Biol. Cell | volume = 13 | issue = 10 | pages = 3627–45 | year = 2003 | pmid = 12388762 | pmc = 129971 | doi = 10.1091/mbc.E02-01-0061 }}
• {{cite journal | vauthors = Bu W, Su LK | title = Characterization of functional domains of human EB1 family proteins | journal = J. Biol. Chem. | volume = 278 | issue = 50 | pages = 49721–31 | year = 2004 | pmid = 14514668 | doi = 10.1074/jbc.M306194200 | doi-access = free }}
• {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2136–44 | year = 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
• {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 | s2cid = 7200157 }}
• {{cite journal | vauthors = Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, Sasaki H, Matsui C, Severin F, Galjart N, Grosveld F, Vorobjev I, Tsukita S, Akhmanova A | title = CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex | journal = J. Cell Biol. | volume = 168 | issue = 1 | pages = 141–53 | year = 2005 | pmid = 15631994 | pmc = 2171674 | doi = 10.1083/jcb.200405094 }}
• {{cite journal | vauthors = Xu H, Hebert MD | title = A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin | journal = BMC Cell Biol. | volume = 6 | issue = 1 | pages = 23 | year = 2006 | pmid = 15862129 | pmc = 1097723 | doi = 10.1186/1471-2121-6-23 | doi-access = free }}
• {{cite journal | vauthors = Wang Y, Zhou X, Zhu H, Liu S, Zhou C, Zhang G, Xue L, Lu N, Quan L, Bai J, Zhan Q, Xu N | title = Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway | journal = Oncogene | volume = 24 | issue = 44 | pages = 6637–45 | year = 2005 | pmid = 16007168 | doi = 10.1038/sj.onc.1208819 | s2cid = 36511735 | doi-access = }}

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