MARCH2
{{Short description|Protein-coding gene in the species Homo sapiens}}
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E3 ubiquitin-protein ligase MARCH2 is an enzyme that in humans is encoded by the MARCH2 gene.{{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Research | volume = 10 | issue = 10 | pages = 1546–60 | date = October 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}{{cite journal | vauthors = Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Früh K | title = Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins | journal = Journal of Virology | volume = 78 | issue = 3 | pages = 1109–20 | date = February 2004 | pmid = 14722266 | pmc = 321412 | doi = 10.1128/JVI.78.3.1109-1120.2004 }}{{cite web | title = Entrez Gene: MARCH2 membrane-associated ring finger (C3HC4) 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51257}} It is a member of the MARCH family of E3 ligases, and plays an important role in the turnover of membrane proteins.{{cite journal | vauthors = Zhang Y, Lu J, Liu X | title = MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation | journal = Virology | volume = 518 | pages = 293–300 | date = May 2018 | pmid = 29573664 | doi = 10.1016/j.virol.2018.02.003 | doi-access = }} MARCH2 has been shown to negatively regulate NF-κB essential modulator function upon viral and bacterial infections.{{cite journal | doi=10.15252/embj.2020105139 | title=Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2 | year=2020 | last1=Chathuranga | first1=Kiramage | last2=Kim | first2=Tae-Hwan | last3=Lee | first3=Hyuncheol | last4=Park | first4=Jun-Seol | last5=Kim | first5=Jae-Hoon | last6=Chathuranga | first6=Wijesinghe A Gayan | last7=Ekanayaka | first7=Pathum | last8=Choi | first8=Youn Jung | last9=Lee | first9=Chul-Ho | last10=Kim | first10=Chul-Joong | last11=Jung | first11=Jae U. | last12=Lee | first12=Jong-Soo | journal=The EMBO Journal | volume=39 | issue=21 | pages=e105139 | pmid=32935379 | pmc=7604578 | s2cid=221745904 }}
Gene name error in Excel
{{Main|Microsoft Excel#Conversion_problems}}
Like the other MARCH and septin genes, care must be exercised when analyzing genetic data containing the MARCH2 gene in Microsoft Excel.{{cite journal | vauthors = Zeeberg BR, Riss J, Kane DW, Bussey KJ, Uchio E, Linehan WM, Barrett JC, Weinstein JN | display-authors = 6 | title = Mistaken identifiers: gene name errors can be introduced inadvertently when using Excel in bioinformatics | journal = BMC Bioinformatics | volume = 5 | issue = 1 | pages = 80 | date = June 2004 | pmid = 15214961 | pmc = 459209 | doi = 10.1186/1471-2105-5-80 | doi-access = free }} This is due to Excel's autocorrect feature treating the MARCH gene as a date and converting it to a standard date format. The original text cannot be recovered as a result of the conversion. A 2016 study found up to 19.6% of all papers in selected journals to be affected by the gene name error.{{cite journal | vauthors = Ziemann M, Eren Y, El-Osta A | title = Gene name errors are widespread in the scientific literature | journal = Genome Biology | volume = 17 | issue = 1 | pages = 177 | date = August 2016 | pmid = 27552985 | pmc = 4994289 | doi = 10.1186/s13059-016-1044-7 | doi-access = free }} The issue can be prevented by using an alias name such as MARCHF2, prepending with an apostrophe ('), or preformatting the cell as text.
References
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Further reading
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- {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = April 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
- {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = April 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
- {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = June 2004 | pmid = 15146197 | doi = 10.1038/nbt971 | s2cid = 27764390 }}
- {{cite journal | vauthors = Nakamura N, Fukuda H, Kato A, Hirose S | title = MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking | journal = Molecular Biology of the Cell | volume = 16 | issue = 4 | pages = 1696–710 | date = April 2005 | pmid = 15689499 | pmc = 1073653 | doi = 10.1091/mbc.E04-03-0216 }}
- {{cite journal | vauthors = Fukuda H, Nakamura N, Hirose S | title = MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II | journal = Journal of Biochemistry | volume = 139 | issue = 1 | pages = 137–45 | date = January 2006 | pmid = 16428329 | doi = 10.1093/jb/mvj012 | url = https://zenodo.org/record/895647 }}
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