MARCKSL1

This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. MARCKS plays a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junctions. Alternative splicing results in multiple transcript variants.

MARCKSL1 has been shown to interact with DCTN2{{cite journal |vauthors=Yue L, Lu S, Garces J, Jin T, Li J | title = Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading | journal = J. Biol. Chem. | volume = 275 | issue = 31 | pages = 23948–56 | date = August 2000 | pmid = 10827182 | doi = 10.1074/jbc.M001845200 | doi-access = free }} and JNK.{{cite journal |vauthors=Björkblom B, Padzik A, Mohammad H, Westerlund N, Komulainen E, Hollos P, Parviainen L, Papageorgiou AC, Iljin K, Kallioniemi O, Kallajoki M, Courtney MJ, Mågård M, James P, Coffey ET | title = c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells | journal = Mol Cell Biol | volume = 32 | issue = 17 | pages = 3513–26 | date = September 2012 | pmid = 22751924 | doi = 10.1128/MCB.00713-12 | pmc=3421996}}

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• {{cite journal |vauthors=Umekage T, Kato K | title = A mouse brain cDNA encodes a novel protein with the protein kinase C phosphorylation site domain common to MARCKS. | journal = FEBS Lett. | volume = 286 | issue = 1–2 | pages = 147–51 | year = 1991 | pmid = 1864362 | doi = 10.1016/0014-5793(91)80961-2 | doi-access = free }}
• {{cite journal |vauthors=Verghese GM, Johnson JD, Vasulka C, Haupt DM, Stumpo DJ, Blackshear PJ | title = Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein. | journal = J. Biol. Chem. | volume = 269 | issue = 12 | pages = 9361–7 | year = 1994 | doi = 10.1016/S0021-9258(17)37116-8 | pmid = 8132675 | doi-access = free }}
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• {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}

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