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MBOAT7

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Lysophospholipid acyltransferase 7 also known as membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is an enzyme that in humans is encoded by the MBOAT7 gene.{{cite web | title = Entrez Gene: Membrane bound O-acyltransferase domain containing 7 | url = https://www.ncbi.nlm.nih.gov/gene/79143 }}

It is homologous to other membrane-bound O-acyltransferases.{{cite journal|title=Acyl-CoA:Lysophospholipid Acyltransferases|vauthors=Shindou H, Shimizu T|journal=Journal of Biological Chemistry|year=2009|volume=284|issue=1|pages=1–5|doi=10.1074/jbc.R800046200|doi-access=free|pmid=18718904}}{{cite journal|title=The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification|vauthors=Wang K, Lee CW, Sui X, Kim S, Wang S, Higgs AB, Baublis AJ, Voth GA, Lao M, Walther TC, Farese Jr RV|journal=Nature Communications|volume=14|id=Art. No. 3533|year=2023|issue=1 |page=3533 |doi=10.1038/s41467-023-38932-5|doi-access=free|pmid=37316513|pmc=10267149|bibcode=2023NatCo..14.3533W }}

Function

This gene encodes a member of the membrane-bound O-acyltransferase family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the re-acylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle.

References

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Further reading

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  • {{cite journal |vauthors=Wende H, Volz A, Ziegler A | title = Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster | journal = Immunogenetics | volume = 51 | issue = 8–9 | pages = 703–13 |date=July 2000 | pmid = 10941842 | doi = 10.1007/s002510000187| s2cid = 20719684 }}
  • {{cite journal |vauthors=Lee HC, Inoue T, Imae R, Kono N, Shirae S, Matsuda S, Gengyo-Ando K, Mitani S, Arai H | title = Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol | journal = Mol. Biol. Cell | volume = 19 | issue = 3 | pages = 1174–84 |date=March 2008 | pmid = 18094042 | pmc = 2262980 | doi = 10.1091/mbc.E07-09-0893 }}
  • {{cite journal |vauthors=Shindou H, Hishikawa D, Harayama T, Yuki K, Shimizu T | title = Recent progress on acyl CoA: lysophospholipid acyltransferase research | journal = J. Lipid Res. | volume = 50 Suppl | pages = S46–51 |date=April 2009 | issue = Suppl | pmid = 18931347 | pmc = 2674719 | doi = 10.1194/jlr.R800035-JLR200 |doi-access=free }}
  • {{cite journal |vauthors=Gijón MA, Riekhof WR, Zarini S, Murphy RC, Voelker DR | title = Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils | journal = J. Biol. Chem. | volume = 283 | issue = 44 | pages = 30235–45 |date=October 2008 | pmid = 18772128 | pmc = 2573059 | doi = 10.1074/jbc.M806194200 | doi-access = free }}
  • {{cite journal |vauthors=Fukunaga-Johnson N, Lee SW, Liebert M, Grossman HB | title = Molecular analysis of a gene, BB1, overexpressed in bladder and breast carcinoma | journal = Anticancer Res. | volume = 16 | issue = 3A | pages = 1085–90 | year = 1996 | pmid = 8702217 }}

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