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MCF2

{{Short description|Protein-coding gene in the humans}}

{{Infobox_gene}}

Proto-oncogene DBL is a protein that in humans is encoded by the MCF2 gene.{{cite journal | vauthors = Noguchi T, Galland F, Batoz M, Mattei MG, Birnbaum D | title = Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences | journal = Oncogene | volume = 3 | issue = 6 | pages = 709–15 | date = December 1988 | pmid = 2577874 }}{{cite journal | vauthors = Galland F, Stefanova M, Lafage M, Birnbaum D | title = Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23 | journal = Cytogenetics and Cell Genetics | volume = 60 | issue = 2 | pages = 114–6 | date = Jul 1992 | pmid = 1611909 | doi = 10.1159/000133316 }}{{cite web | title = Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4168}}

The commonly-used name DBL is derived from “diffuse B-cell lymphoma”, the cancer type where this gene was first identified as an oncogene,{{cite journal | vauthors = Eva A, Aaronson SA | title = Isolation of a new human oncogene from a diffuse B-cell lymphoma | journal = Nature | volume = 316 | issue = 6025 | pages = 273–5 | date = 1985-07-18 | pmid = 3875039 | doi = 10.1038/316273a0 | bibcode = 1985Natur.316..273E | s2cid = 4268140 }} while the name MCF2 name derives from “MCF.2 cell line-derived transforming sequence”.{{cite journal | vauthors = Noguchi T, Mattei MG, Oberlè I, Planche J, Imbert J, Pelassy C, Birg F, Birnbaum D | display-authors = 6 | title = Localization of the mcf.2 transforming sequence to the X chromosome | journal = The EMBO Journal | volume = 6 | issue = 5 | pages = 1301–7 | date = May 1987 | pmid = 3038515 | pmc = 553933 | doi = 10.1002/j.1460-2075.1987.tb02368.x }}

DBL is the founding member of a large family of guanine nucleotide exchange factors that share a common DBL-homology (DH) domain), so DBL is also named as a member of this RhoGEF family as ARHGEF21. DH domains function to activate small GTPases of the Rho family by facilitating release of GDP from an inactive Rho GTPase and binding of GTP to activate it. In particular, DBL activates the Rho family member Cdc42.{{cite journal | vauthors = Fort P, Blangy A | title = The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals | journal = Genome Biology and Evolution | volume = 9 | issue = 6 | pages = 1471–1486 | date = June 2017 | pmid = 28541439 | pmc = 5499878 | doi = 10.1093/gbe/evx100 }}

Gene recombinations that result in the loss of N-terminal regions produce MCF2 variants with oncogenic activity.[supplied by OMIM]

References

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Further reading

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  • {{cite journal | vauthors = Ron D, Zannini M, Lewis M, Wickner RB, Hunt LT, Graziani G, Tronick SR, Aaronson SA, Eva A | display-authors = 6 | title = A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr | journal = The New Biologist | volume = 3 | issue = 4 | pages = 372–9 | date = April 1991 | pmid = 2065022 }}
  • {{cite journal | vauthors = Tronick SR, McBride OW, Popescu NC, Eva A | title = Chromosomal localization of DBL oncogene sequences | journal = Genomics | volume = 5 | issue = 3 | pages = 546–53 | date = October 1989 | pmid = 2613238 | doi = 10.1016/0888-7543(89)90022-0 | url = https://zenodo.org/record/1258565 }}
  • {{cite journal | vauthors = Ron D, Tronick SR, Aaronson SA, Eva A | title = Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells | journal = The EMBO Journal | volume = 7 | issue = 8 | pages = 2465–73 | date = August 1988 | pmid = 3056717 | pmc = 457116 | doi = 10.1002/j.1460-2075.1988.tb03093.x}}
  • {{cite journal | vauthors = Eva A, Vecchio G, Rao CD, Tronick SR, Aaronson SA | title = The predicted DBL oncogene product defines a distinct class of transforming proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 85 | issue = 7 | pages = 2061–5 | date = April 1988 | pmid = 3281159 | pmc = 279928 | doi = 10.1073/pnas.85.7.2061 | bibcode = 1988PNAS...85.2061E | doi-access = free }}
  • {{cite journal | vauthors = Srivastava SK, Wheelock RH, Aaronson SA, Eva A | title = Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 83 | issue = 23 | pages = 8868–72 | date = December 1986 | pmid = 3491366 | pmc = 387034 | doi = 10.1073/pnas.83.23.8868 | bibcode = 1986PNAS...83.8868S | doi-access = free }}
  • {{cite journal | vauthors = Hart MJ, Eva A, Zangrilli D, Aaronson SA, Evans T, Cerione RA, Zheng Y | title = Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product | journal = The Journal of Biological Chemistry | volume = 269 | issue = 1 | pages = 62–5 | date = January 1994 | doi = 10.1016/S0021-9258(17)42313-1 | pmid = 8276860 | doi-access = free }}
  • {{cite journal | vauthors = Nishida K, Kaziro Y, Satoh T | title = Association of the proto-oncogene product dbl with G protein betagamma subunits | journal = FEBS Letters | volume = 459 | issue = 2 | pages = 186–90 | date = October 1999 | pmid = 10518015 | doi = 10.1016/S0014-5793(99)01244-2 | s2cid = 83524892 | doi-access = | bibcode = 1999FEBSL.459..186N }}
  • {{cite journal | vauthors = Kato J, Kaziro Y, Satoh T | title = Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation | journal = Biochemical and Biophysical Research Communications | volume = 268 | issue = 1 | pages = 141–7 | date = February 2000 | pmid = 10652228 | doi = 10.1006/bbrc.2000.2106 }}
  • {{cite journal | vauthors = Zhu K, Debreceni B, Li R, Zheng Y | title = Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation | journal = The Journal of Biological Chemistry | volume = 275 | issue = 34 | pages = 25993–6001 | date = August 2000 | pmid = 10854437 | doi = 10.1074/jbc.M003780200 | doi-access = free }}
  • {{cite journal | vauthors = Palmieri G, de Franciscis V, Casamassimi A, Romano G, Torino A, Pingitore P, Califano D, Santelli G, Eva A, Vecchio G, D'Urso M, Ciccodicola A | display-authors = 6 | title = Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site | journal = Gene | volume = 253 | issue = 1 | pages = 107–15 | date = July 2000 | pmid = 10925207 | doi = 10.1016/S0378-1119(00)00212-2 }}
  • {{cite journal | vauthors = Jin S, Exton JH | title = Activation of RhoA by association of Galpha(13) with Dbl | journal = Biochemical and Biophysical Research Communications | volume = 277 | issue = 3 | pages = 718–21 | date = November 2000 | pmid = 11062019 | doi = 10.1006/bbrc.2000.3744 }}
  • {{cite journal | vauthors = Zhu K, Debreceni B, Bi F, Zheng Y | title = Oligomerization of DH domain is essential for Dbl-induced transformation | journal = Molecular and Cellular Biology | volume = 21 | issue = 2 | pages = 425–37 | date = January 2001 | pmid = 11134331 | pmc = 86589 | doi = 10.1128/MCB.21.2.425-437.2001 }}
  • {{cite journal | vauthors = Vanni C, Mancini P, Gao Y, Ottaviano C, Guo F, Salani B, Torrisi MR, Zheng Y, Eva A | display-authors = 6 | title = Regulation of proto-Dbl by intracellular membrane targeting and protein stability | journal = The Journal of Biological Chemistry | volume = 277 | issue = 22 | pages = 19745–53 | date = May 2002 | pmid = 11907027 | doi = 10.1074/jbc.M111025200 | doi-access = free }}
  • {{cite journal | vauthors = Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ | title = RhoG signals in parallel with Rac1 and Cdc42 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 49 | pages = 47810–7 | date = December 2002 | pmid = 12376551 | doi = 10.1074/jbc.M203816200 | doi-access = free }}
  • {{cite journal | vauthors = Komai K, Okayama R, Kitagawa M, Yagi H, Chihara K, Shiozawa S | title = Alternative splicing variants of the human DBL (MCF-2) proto-oncogene | journal = Biochemical and Biophysical Research Communications | volume = 299 | issue = 3 | pages = 455–8 | date = December 2002 | pmid = 12445822 | doi = 10.1016/S0006-291X(02)02645-1 | hdl = 20.500.14094/D2002682 | hdl-access = free }}
  • {{cite journal | vauthors = Komai K, Mukae-Sakairi N, Kitagawa M, Shiozawa S | title = Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene | journal = Biochemical and Biophysical Research Communications | volume = 309 | issue = 4 | pages = 906–9 | date = October 2003 | pmid = 13679059 | doi = 10.1016/j.bbrc.2003.08.088 | s2cid = 26656167 | url = http://www.lib.kobe-u.ac.jp/repository/90000273.pdf | access-date = 2020-09-08 | archive-date = 2018-11-02 | archive-url = https://web.archive.org/web/20181102002724/http://www.lib.kobe-u.ac.jp/repository/90000273.pdf | url-status = dead }}
  • {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | display-authors = 6 | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}

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