ME2

ME2 or ME-2 may refer to:

• ME2 (gene)
• "Me²", an episode of the British sitcom Red Dwarf
• Mass Effect 2, a video game released for Microsoft Windows and Xbox 360 in 2010, and for PlayStation 3 in 2011
• Maine's 2nd congressional district
• U.S. Route 2 in Maine
• Me1 vs Me2 Snooker with Richard Herring
• Me Two, French film