MED13

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator.

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• {{cite journal | vauthors = Gu W, Malik S, Ito M, Yuan CX, Fondell JD, Zhang X, Martinez E, Qin J, Roeder RG | title = A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation | journal = Molecular Cell | volume = 3 | issue = 1 | pages = 97–108 | date = Jan 1999 | pmid = 10024883 | doi = 10.1016/S1097-2765(00)80178-1 | doi-access = free }}
• {{cite journal | vauthors = Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM | title = CDK8 is a positive regulator of transcriptional elongation within the serum response network | journal = Nature Structural & Molecular Biology | volume = 17 | issue = 2 | pages = 194–201 | date = Feb 2010 | pmid = 20098423 | pmc = 2920286 | doi = 10.1038/nsmb.1752 }}
• {{cite journal | vauthors = Näär AM, Taatjes DJ, Zhai W, Nogales E, Tjian R | title = Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation | journal = Genes & Development | volume = 16 | issue = 11 | pages = 1339–44 | date = Jun 2002 | pmid = 12050112 | pmc = 186316 | doi = 10.1101/gad.987602 }}
• {{cite journal | vauthors = Fondell JD, Ge H, Roeder RG | title = Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 16 | pages = 8329–33 | date = Aug 1996 | pmid = 8710870 | pmc = 38670 | doi = 10.1073/pnas.93.16.8329 | bibcode = 1996PNAS...93.8329F | doi-access = free }}
• {{cite journal | vauthors = Zhang X, Krutchinsky A, Fukuda A, Chen W, Yamamura S, Chait BT, Roeder RG | title = MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription | journal = Molecular Cell | volume = 19 | issue = 1 | pages = 89–100 | date = Jul 2005 | pmid = 15989967 | doi = 10.1016/j.molcel.2005.05.015 | doi-access = free }}
• {{cite journal | vauthors = Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S | title = BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220 | journal = Oncogene | volume = 23 | issue = 35 | pages = 6000–5 | date = Aug 2004 | pmid = 15208681 | doi = 10.1038/sj.onc.1207786 | doi-access = free }}
• {{cite journal | vauthors = Gustafsson CM, Samuelsson T | title = Mediator--a universal complex in transcriptional regulation | journal = Molecular Microbiology | volume = 41 | issue = 1 | pages = 1–8 | date = Jul 2001 | pmid = 11454195 | doi = 10.1046/j.1365-2958.2001.02481.x | s2cid = 30224146 | doi-access = free }}
• {{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5846–51 | date = Feb 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 | doi-access = free }}
• {{cite journal | vauthors = Kang YK, Guermah M, Yuan CX, Roeder RG | title = The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 5 | pages = 2642–7 | date = Mar 2002 | pmid = 11867769 | pmc = 122401 | doi = 10.1073/pnas.261715899 | bibcode = 2002PNAS...99.2642K | doi-access = free }}

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