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MED17

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Infobox gene}}

Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.{{cite journal |vauthors=Ryu S, Zhou S, Ladurner AG, Tjian R | title = The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1 | journal = Nature | volume = 397 | issue = 6718 | pages = 446–50 |date=Feb 1999 | pmid = 9989412 | doi = 10.1038/17141 | bibcode =1999Natur.397..446R | s2cid = 4405569 | hdl = 11858/00-001M-0000-0019-A36A-8 | hdl-access = free }}{{cite journal |vauthors=Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators | journal = Mol Cell | volume = 3 | issue = 3 | pages = 361–70 |date=Apr 1999 | pmid = 10198638 | doi =10.1016/S1097-2765(00)80463-3 | doi-access = free }}{{cite web | title = Entrez Gene: CRSP6 cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9440}}

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.

Interactions

MED17 has been shown to interact with PPARGC1A,{{cite journal |doi=10.1016/S1097-2765(03)00391-5 |last=Wallberg |first=Annika E |author2=Yamamura Soichiro |author3=Malik Sohail |author4=Spiegelman Bruce M |author5=Roeder Robert G |date=Nov 2003 |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha |journal=Mol. Cell |volume=12 |issue=5 |pages=1137–49 |location = United States| issn = 1097-2765| pmid = 14636573 |doi-access=free }} Cyclin-dependent kinase 8{{cite journal |last=Kang |first=Yun Kyoung |author2=Guermah Mohamed |author3=Yuan Chao-Xing |author4=Roeder Robert G |date=Mar 2002 |title=The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue=5 |pages=2642–7 |location = United States| issn = 0027-8424| pmid = 11867769 |doi = 10.1073/pnas.261715899 | bibcode =2002PNAS...99.2642K |pmc=122401 |doi-access=free }} and BRCA1.{{cite journal |last=Chiba |first=N |author2=Parvin J D |date=Oct 2001 |title=Redistribution of BRCA1 among four different protein complexes following replication blockage |journal=J. Biol. Chem. |volume=276 |issue=42 |pages=38549–54 |location = United States| issn = 0021-9258| pmid = 11504724 |doi = 10.1074/jbc.M105227200 |doi-access=free }}{{cite journal |last=Chiba |first=Natsuko |author2=Parvin Jeffrey D |date=Aug 2002 |title=The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme |journal=Cancer Res. |volume=62 |issue=15 |pages=4222–8 |location = United States| issn = 0008-5472| pmid = 12154023 }}

References

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Further reading

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  • {{cite journal |vauthors=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329–33 |year= 1996 |pmid= 8710870 |doi=10.1073/pnas.93.16.8329 | pmc=38670 |bibcode=1996PNAS...93.8329F |doi-access=free }}
  • {{cite journal |vauthors=Rachez C, Lemon BD, Suldan Z, etal |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. |journal=Nature |volume=398 |issue= 6730 |pages= 824–8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783 |bibcode=1999Natur.398..824R |s2cid=204992765 }}
  • {{cite journal |vauthors=Näär AM, Beaurang PA, Zhou S, etal |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828–32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789 |bibcode=1999Natur.398..828N |s2cid=23646963 }}
  • {{cite journal |vauthors=Chiba N, Parvin JD |title=Redistribution of BRCA1 among four different protein complexes following replication blockage. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 38549–54 |year= 2001 |pmid= 11504724 |doi= 10.1074/jbc.M105227200 |doi-access= free }}
  • {{cite journal |vauthors=Ge K, Guermah M, Yuan CX, etal |title=Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. |journal=Nature |volume=417 |issue= 6888 |pages= 563–7 |year= 2002 |pmid= 12037571 |doi= 10.1038/417563a |bibcode=2002Natur.417..563G |s2cid=4432077 }}
  • {{cite journal |vauthors=Wang Q, Sharma D, Ren Y, Fondell JD |title=A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42852–8 |year= 2003 |pmid= 12218053 |doi= 10.1074/jbc.M206061200 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Lau JF, Nusinzon I, Burakov D, etal |title=Role of metazoan mediator proteins in interferon-responsive transcription. |journal=Mol. Cell. Biol. |volume=23 |issue= 2 |pages= 620–8 |year= 2003 |pmid= 12509459 |doi=10.1128/MCB.23.2.620-628.2003 | pmc=151539 }}
  • {{cite journal |vauthors=Sato S, Tomomori-Sato C, Banks CA, etal |title=Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15123–7 |year= 2003 |pmid= 12584197 |doi= 10.1074/jbc.C300054200 |doi-access= free }}
  • {{cite journal |vauthors=Sato S, Tomomori-Sato C, Banks CA, etal |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671–4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 |doi-access= free }}
  • {{cite journal |vauthors=Wallberg AE, Yamamura S, Malik S, etal |title=Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1137–49 |year= 2004 |pmid= 14636573 |doi=10.1016/S1097-2765(03)00391-5 |doi-access=free }}
  • {{cite journal |vauthors=Tomomori-Sato C, Sato S, Parmely TJ, etal |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846–51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 |doi-access= free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Sato S, Tomomori-Sato C, Parmely TJ, etal |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685–91 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Jang MK, Mochizuki K, Zhou M, etal |title=The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. |journal=Mol. Cell |volume=19 |issue= 4 |pages= 523–34 |year= 2005 |pmid= 16109376 |doi= 10.1016/j.molcel.2005.06.027 |doi-access= free }}
  • {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}

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