MED29

{{Infobox protein family

| Symbol = Med29

| Name = Med29

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| Pfam = PF11568

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| InterPro = IPR021018

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| OPM family =

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Mediator of RNA polymerase II transcription subunit 29 (Med29) is a transcription suppressor that in humans is encoded by the MED29 gene.{{cite journal |vauthors=Wang Y, Li Y, Zeng W, Zhu C, Xiao J, Yuan W, etal | title=IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor. | journal=Biochem Biophys Res Commun | year= 2004 | volume= 325 | issue= 4 | pages= 1330–8 | pmid=15555573 | doi=10.1016/j.bbrc.2004.10.159 }} It represents subunit MED29 of the Mediator complex.

Med29, along with Med11 and Med28 in mammals, is part of the core head-region of the Mediator complex. Med29 is the apparent orthologue of the Drosophila melanogaster Intersex protein (IXL), which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators.{{cite journal |vauthors=Conaway RC, Sato S, Tomomori-Sato C, Yao T, Conaway JW | title = The mammalian Mediator complex and its role in transcriptional regulation | journal = Trends Biochem. Sci. | volume = 30 | issue = 5 | pages = 250–5 |date=May 2005 | pmid = 15896743 | doi = 10.1016/j.tibs.2005.03.002 }}