MED31

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox protein family

| Symbol = Med31

| Name = Med31

| image =

| width =

| caption = structure of the mediator submodule med7n/31

| Pfam = PF05669

| Pfam_clan =

| InterPro = IPR008831

| SMART =

| PROSITE =

| MEROPS =

| SCOP =

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD =

}}

Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene.{{cite journal |vauthors=Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | journal = Genome Res | volume = 10 | issue = 5 | pages = 703–713 |date=Aug 2000 | pmid = 10810093 | pmc = 310876 | doi =10.1101/gr.10.5.703 }}{{cite web | title = Entrez Gene: MED31 mediator of RNA polymerase II transcription, subunit 31 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51003}} It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant{{cite journal |vauthors=Fan HY, Klein HL | title = Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae | journal = Genetics | volume = 137 | issue = 4 | pages = 945–56 |date=August 1994 | doi = 10.1093/genetics/137.4.945 | pmid = 7982575 | pmc = 1206071 }} and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.{{cite journal |vauthors=Fan HY, Cheng KK, Klein HL | title = Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae | journal = Genetics | volume = 142 | issue = 3 | pages = 749–59 |date=March 1996 | doi = 10.1093/genetics/142.3.749 | pmid = 8849885 | pmc = 1207016 }}

References

{{cite journal | author=Gu W |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97–108 |year= 1999 |pmid= 10024883 |doi=10.1016/S1097-2765(00)80178-1 |name-list-style=vanc| author2=Malik S | author3=Ito M | display-authors=3 | last4=Yuan | first4=Chao-Xing | last5=Fondell | first5=Joseph D | last6=Zhang | first6=Xiaolong | last7=Martinez | first7=Ernest | last8=Qin | first8=Jun | last9=Roeder | first9=Robert G | doi-access=free }}
{{cite journal | author=Suzuki H |title=Protein-protein interaction panel using mouse full-length cDNAs |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–1765 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 | pmc=311163 |name-list-style=vanc| author2=Fukunishi Y | author3=Kagawa I | display-authors=3 | last4=Saito | first4=R | last5=Oda | first5=H | last6=Endo | first6=T | last7=Kondo | first7=S | last8=Bono | first8=H | last9=Okazaki | first9=Y }}
{{cite journal | author=Brower CS |title=Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 16 |pages= 10353–10358 |year= 2002 |pmid= 12149480 |doi= 10.1073/pnas.162424199 | pmc=124918 |name-list-style=vanc| author2=Sato S | author3=Tomomori-Sato C | display-authors=3 | last4=Kamura | first4=T | last5=Pause | first5=A | last6=Stearman | first6=R | last7=Klausner | first7=RD | last8=Malik | first8=S | last9=Lane | first9=WS |bibcode=2002PNAS...9910353B |doi-access=free }}
{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal | author=Sato S |title=Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15123–15127 |year= 2003 |pmid= 12584197 |doi= 10.1074/jbc.C300054200 |name-list-style=vanc| author2=Tomomori-Sato C | author3=Banks CA | display-authors=3 | last4=Sorokina | first4=I | last5=Parmely | first5=TJ | last6=Kong | first6=SE | last7=Jin | first7=J | last8=Cai | first8=Y | last9=Lane | first9=WS | doi-access=free }}
{{cite journal | author=Sato S |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671–49674 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 |name-list-style=vanc| author2=Tomomori-Sato C | author3=Banks CA | display-authors=3 | last4=Parmely | first4=TJ | last5=Sorokina | first5=I | last6=Brower | first6=CS | last7=Conaway | first7=RC | last8=Conaway | first8=JW | doi-access=free }}
{{cite journal | author=Tomomori-Sato C |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846–5851 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 |name-list-style=vanc| author2=Sato S | author3=Parmely TJ | display-authors=3 | last4=Banks | first4=CA | last5=Sorokina | first5=I | last6=Florens | first6=L | last7=Zybailov | first7=B | last8=Washburn | first8=MP | last9=Brower | first9=CS | doi-access=free }}
{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
{{cite journal | author=Sato S |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685–691 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006 |name-list-style=vanc| author2=Tomomori-Sato C | author3=Parmely TJ | display-authors=3 | last4=Florens | first4=Laurence | last5=Zybailov | first5=Boris | last6=Swanson | first6=Selene K | last7=Banks | first7=Charles A.S | last8=Jin | first8=Jingji | last9=Cai | first9=Yong | doi-access=free }}
{{cite journal | author=Goehler H |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–865 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 |name-list-style=vanc| author2=Lalowski M | author3=Stelzl U | display-authors=3 | last4=Waelter | first4=Stephanie | last5=Stroedicke | first5=Martin | last6=Worm | first6=Uwe | last7=Droege | first7=Anja | last8=Lindenberg | first8=Katrin S. | last9=Knoblich | first9=Maria | doi-access=free }}
{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
{{cite journal | author=Stelzl U |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–968 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |name-list-style=vanc| author2=Worm U | author3=Lalowski M | display-authors=3 | last4=Haenig | first4=Christian | last5=Brembeck | first5=Felix H. | last6=Goehler | first6=Heike | last7=Stroedicke | first7=Martin | last8=Zenkner | first8=Martina | last9=Schoenherr | first9=Anke | doi-access=free | hdl=11858/00-001M-0000-0010-8592-0 | hdl-access=free }}

Category:Protein families

MED31

References

Further reading